BRIP1 (BRCA1 interacting helicase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: BRIP1 (BRCA1 interacting helicase 1) Canis lupus familiaris
Analyze
Symbol: BRIP1
Name: BRCA1 interacting helicase 1
RGD ID: 12430342
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to angiotensin (ortholog); cellular response to hypoxia (ortholog); cellular response to vitamin (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); Bone Metastasis (ortholog); FOUND IN BRCA1-B complex (ortholog); replication fork (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BRCA1 interacting protein C-terminal helicase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,804,285 - 34,984,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,806,535 - 34,983,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha934,033,470 - 34,213,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,614,312 - 35,794,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,614,404 - 35,793,717 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1934,396,970 - 34,580,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,682,046 - 34,865,676 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,768,817 - 34,949,171 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,804,285 - 34,984,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,806,535 - 34,983,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha934,033,470 - 34,213,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,614,312 - 35,794,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,614,404 - 35,793,717 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1934,396,970 - 34,580,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,682,046 - 34,865,676 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,768,817 - 34,949,171 (+)NCBIUU_Cfam_GSD_1.0
BRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381761,679,139 - 61,863,528 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1761,679,139 - 61,863,559 (-)EnsemblGRCh38hg38GRCh38
GRCh371759,756,500 - 59,940,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361757,114,767 - 57,295,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341757,114,766 - 57,295,537NCBI
Celera1758,857,566 - 59,042,100 (-)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1755,122,899 - 55,306,703 (-)NCBIHuRef
CHM1_11759,821,037 - 60,005,473 (-)NCBICHM1_1
T2T-CHM13v2.01762,547,944 - 62,734,245 (-)NCBIT2T-CHM13v2.0
Brip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,948,957 - 86,092,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,948,964 - 86,092,019 (-)EnsemblGRCm39 Ensembl
GRCm381186,058,136 - 86,201,215 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,058,138 - 86,201,193 (-)EnsemblGRCm38mm10GRCm38
MGSCv371185,871,640 - 86,014,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,874,331 - 86,017,388 (-)NCBIMGSCv36mm8
Celera1195,685,510 - 95,821,501 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.61NCBI
Brip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,402,035 - 71,528,083 (-)NCBIGRCr8
mRatBN7.21070,907,266 - 71,031,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1070,907,371 - 71,030,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01073,507,009 - 73,632,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,507,100 - 73,629,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,408,318 - 73,533,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,313,004 - 74,436,532 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,327,690 - 74,448,583 (-)NCBI
Celera1069,829,617 - 69,953,629 (-)NCBICelera
Cytogenetic Map10q26NCBI
Brip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554512,707,793 - 2,818,592 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554512,705,834 - 2,820,610 (-)NCBIChiLan1.0ChiLan1.0
BRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21977,877,272 - 78,065,251 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11782,695,007 - 82,883,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01755,786,568 - 55,973,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11760,901,073 - 61,083,462 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1760,901,073 - 61,083,462 (-)Ensemblpanpan1.1panPan2
Brip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,935,468 - 34,073,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364903,003,484 - 3,137,479 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364903,001,445 - 3,139,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,498,205 - 36,635,973 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,498,138 - 36,639,847 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,871,343 - 37,957,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11632,909,226 - 33,085,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1632,910,693 - 33,082,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660773,666,211 - 3,849,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248712,052,863 - 2,198,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248712,051,044 - 2,195,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BRIP1
1242 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 1 8
Below cutoff 4 5 22 6 6 6 5 6 12 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028135   ⟹   ENSCAFP00000026175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl934,806,535 - 34,983,788 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845047739   ⟹   ENSCAFP00845037460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl935,614,404 - 35,793,717 (+)Ensembl
RefSeq Acc Id: XM_038486140   ⟹   XP_038342068
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1934,396,970 - 34,580,604 (+)NCBI
RefSeq Acc Id: XM_038547960   ⟹   XP_038403888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0934,768,817 - 34,949,171 (+)NCBI
RefSeq Acc Id: XM_038611925   ⟹   XP_038467853
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0934,682,046 - 34,865,676 (+)NCBI
RefSeq Acc Id: XM_038677165   ⟹   XP_038533093
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0935,614,312 - 35,794,767 (+)NCBI
RefSeq Acc Id: XM_847556   ⟹   XP_852649
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1934,804,285 - 34,984,640 (+)NCBI
Dog10K_Boxer_Tasha934,033,470 - 34,213,752 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_852649   ⟸   XM_847556
- UniProtKB: A0A8I3Q1K5 (UniProtKB/TrEMBL),   A0A8P0SM10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026175   ⟸   ENSCAFT00000028135
RefSeq Acc Id: XP_038342068   ⟸   XM_038486140
RefSeq Acc Id: XP_038467853   ⟸   XM_038611925
RefSeq Acc Id: XP_038533093   ⟸   XM_038677165
- UniProtKB: A0A8I3Q1K5 (UniProtKB/TrEMBL),   A0A8P0SM10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403888   ⟸   XM_038547960
- UniProtKB: A0A8I3Q1K5 (UniProtKB/TrEMBL),   A0A8P0SM10 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845037460   ⟸   ENSCAFT00845047739
Protein Domains
Helicase ATP-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017737 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845027066 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028135.4 UniProtKB/TrEMBL
  ENSCAFT00845047739 ENTREZGENE
  ENSCAFT00845047739.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ATP-dep_Helicase_C UniProtKB/TrEMBL
  DEAD_2 UniProtKB/TrEMBL
  DinG/Rad3-like UniProtKB/TrEMBL
  Helic_SF1/SF2_ATP-bd_DinG/Rad3 UniProtKB/TrEMBL
  Helicase-like_DEXD_c2 UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Rad3/Chl1-like UniProtKB/TrEMBL
NCBI Gene BRIP1 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP J PROTEIN UniProtKB/TrEMBL
  PTHR11472 UniProtKB/TrEMBL
Pfam DEAD_2 UniProtKB/TrEMBL
  Helicase_C_2 UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_2 UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  DEXDc2 UniProtKB/TrEMBL
  HELICc2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I3Q1K5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SM10 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38530 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-15 BRIP1  BRCA1 interacting helicase 1  BRIP1  BRCA1 interacting protein C-terminal helicase 1  Symbol and/or name change 19259463 PROVISIONAL