DNAJB8 (DnaJ heat shock protein family (Hsp40) member B8) - Rat Genome Database

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Gene: DNAJB8 (DnaJ heat shock protein family (Hsp40) member B8) Canis lupus familiaris
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Symbol: DNAJB8
Name: DnaJ heat shock protein family (Hsp40) member B8
RGD ID: 12417886
Description: ENCODES a protein that exhibits Hsp70 protein binding (inferred); protein folding chaperone (inferred); protein-folding chaperone binding (inferred); INVOLVED IN chaperone-mediated protein folding (ortholog); ASSOCIATED WITH alkaptonuria (ortholog); genetic disease (ortholog); immunodeficiency 21 (ortholog); FOUND IN cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dnaJ homolog subfamily B member 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,453,100 - 2,454,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,453,297 - 2,453,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,489,157 - 2,490,263 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0202,473,546 - 2,474,652 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl202,473,664 - 2,474,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1202,194,324 - 2,195,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0202,520,974 - 2,522,079 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0202,481,266 - 2,482,371 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DNAJB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,453,100 - 2,454,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,453,297 - 2,453,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,489,157 - 2,490,263 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0202,473,546 - 2,474,652 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl202,473,664 - 2,474,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1202,194,324 - 2,195,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0202,520,974 - 2,522,079 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0202,481,266 - 2,482,371 (-)NCBIUU_Cfam_GSD_1.0
DNAJB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383128,462,437 - 128,466,890 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3128,462,437 - 128,466,968 (-)EnsemblGRCh38hg38GRCh38
GRCh373128,181,280 - 128,185,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,663,972 - 129,668,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 343129,663,979 - 129,668,789NCBI
Celera3126,609,282 - 126,614,086 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3125,565,298 - 125,570,109 (-)NCBIHuRef
CHM1_13128,144,266 - 128,149,077 (-)NCBICHM1_1
T2T-CHM13v2.03131,204,036 - 131,208,509 (-)NCBIT2T-CHM13v2.0
Dnajb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,199,250 - 88,200,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl688,199,250 - 88,231,397 (+)EnsemblGRCm39 Ensembl
GRCm38688,222,268 - 88,223,256 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,222,268 - 88,254,415 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,172,262 - 88,173,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36688,187,909 - 88,188,897 (+)NCBIMGSCv36mm8
Celera690,159,479 - 90,160,467 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.25NCBI
Dnajb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84122,239,209 - 122,242,277 (+)NCBIGRCr8
mRatBN7.24120,681,918 - 120,685,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4120,681,926 - 120,687,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4126,154,380 - 126,155,375 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,929,139 - 121,930,134 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04120,553,389 - 120,554,384 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04120,156,640 - 120,159,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,156,659 - 120,159,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04185,398,092 - 185,401,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,302,712 - 122,303,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4109,638,313 - 109,639,308 (+)NCBICelera
Cytogenetic Map4q34NCBI
Dnajb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,349,564 - 15,350,268 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,349,346 - 15,350,343 (+)NCBIChiLan1.0ChiLan1.0
DNAJB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,388,321 - 126,392,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13126,393,043 - 126,396,863 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03125,509,528 - 125,514,393 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13132,873,768 - 132,878,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,873,880 - 132,874,578 (-)Ensemblpanpan1.1panPan2
Dnajb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,383,061 - 20,384,148 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936798425,182 - 425,880 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936798425,156 - 425,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1372,013,182 - 72,013,877 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11372,010,213 - 72,015,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,559,447 - 79,560,473 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJB8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,579,012 - 52,580,072 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2252,579,259 - 52,579,957 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041113,777,419 - 113,778,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajb8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624961170,909 - 171,985 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DNAJB8
8 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 7 1
Low 1 1 2 1
Below cutoff 1 8 2 1 2 1 3 2 2

Sequence


RefSeq Acc Id: ENSCAFT00000006631   ⟹   ENSCAFP00000006139
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl202,453,297 - 2,453,650 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033312   ⟹   ENSCAFP00845026077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl202,473,664 - 2,474,365 (-)Ensembl
RefSeq Acc Id: XM_038426762   ⟹   XP_038282690
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0202,473,546 - 2,474,652 (-)NCBI
RefSeq Acc Id: XM_038502570   ⟹   XP_038358498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1202,194,324 - 2,195,430 (-)NCBI
RefSeq Acc Id: XM_038565480   ⟹   XP_038421408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0202,481,266 - 2,482,371 (-)NCBI
RefSeq Acc Id: XM_038629601   ⟹   XP_038485529
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0202,520,974 - 2,522,079 (-)NCBI
RefSeq Acc Id: XM_846718   ⟹   XP_851811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1202,453,100 - 2,454,152 (-)NCBI
Dog10K_Boxer_Tasha202,489,157 - 2,490,263 (-)NCBI
Sequence:
RefSeq Acc Id: XP_851811   ⟸   XM_846718
- UniProtKB: A0A8C0JWI4 (UniProtKB/TrEMBL),   A0A8C0TYE4 (UniProtKB/TrEMBL),   A0A8I3PFA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000006139   ⟸   ENSCAFT00000006631
RefSeq Acc Id: XP_038358498   ⟸   XM_038502570
RefSeq Acc Id: XP_038485529   ⟸   XM_038629601
RefSeq Acc Id: XP_038282690   ⟸   XM_038426762
- UniProtKB: A0A8C0JWI4 (UniProtKB/TrEMBL),   A0A8C0TYE4 (UniProtKB/TrEMBL),   A0A8I3PFA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421408   ⟸   XM_038565480
- UniProtKB: A0A8C0JWI4 (UniProtKB/TrEMBL),   A0A8C0TYE4 (UniProtKB/TrEMBL),   A0A8I3PFA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026077   ⟸   ENSCAFT00845033312
Protein Domains
J


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004138 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00000054979 UniProtKB/TrEMBL
  ENSCAFG00040025925 UniProtKB/TrEMBL
  ENSCAFG00040025926 UniProtKB/TrEMBL
  ENSCAFG00845018870 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006631.6 UniProtKB/TrEMBL
  ENSCAFT00000097085.1 UniProtKB/TrEMBL
  ENSCAFT00040048504.1 UniProtKB/TrEMBL
  ENSCAFT00040048505.1 UniProtKB/TrEMBL
  ENSCAFT00845033312 ENTREZGENE
  ENSCAFT00845033312.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
InterPro DnaJ_domain UniProtKB/TrEMBL
  DnaJ_domain_CS UniProtKB/TrEMBL
  DNJB2/6-like UniProtKB/TrEMBL
  J_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:609460 UniProtKB/TrEMBL
NCBI Gene DNAJB8 ENTREZGENE
PANTHER DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B8 UniProtKB/TrEMBL
  DNAJ HOMOLOG SUBFAMILY B MEMBER 2 UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/TrEMBL
PRINTS JDOMAIN UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/TrEMBL
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP SSF46565 UniProtKB/TrEMBL
UniProt A0A8C0JWI4 ENTREZGENE
  A0A8C0TYE4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z7I7_CANLF UniProtKB/TrEMBL
  A0A8I3PFA3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54595 ENTREZGENE