ADAM8 (ADAM metallopeptidase domain 8) - Rat Genome Database

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Gene: ADAM8 (ADAM metallopeptidase domain 8) Canis lupus familiaris
Analyze
Symbol: ADAM8
Name: ADAM metallopeptidase domain 8
RGD ID: 12382623
Description: ENCODES a protein that exhibits immunoglobulin receptor binding (ortholog); tumor necrosis factor receptor superfamily binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); signal release (ortholog); ASSOCIATED WITH asthma (ortholog); Chemical and Drug Induced Liver Injury (ortholog); distal 10q deletion syndrome (ortholog); FOUND IN alpha9-beta1 integrin-ADAM8 complex (inferred); cell surface (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,853,665 - 40,865,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,853,665 - 40,865,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBIUU_Cfam_GSD_1.0
ADAM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,262,423 - 133,276,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,262,420 - 133,276,868 (-)EnsemblGRCh38hg38GRCh38
GRCh3710135,075,927 - 135,090,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,925,911 - 134,940,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410134,964,788 - 134,979,211NCBI
Celera10128,426,024 - 128,440,474 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,622,621 - 128,637,236 (-)NCBIHuRef
CHM1_110135,357,756 - 135,372,278 (-)NCBICHM1_1
T2T-CHM13v2.010134,218,053 - 134,232,489 (-)NCBIT2T-CHM13v2.0
Adam8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,558,845 - 139,573,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)EnsemblGRCm39 Ensembl
GRCm387139,978,932 - 139,995,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv377147,164,840 - 147,178,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,830,261 - 139,843,808 (-)NCBIMGSCv36mm8
Celera7139,782,797 - 139,796,305 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.96NCBI
Adam8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,206,206 - 204,218,988 (-)NCBIGRCr8
mRatBN7.21194,776,559 - 194,789,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01212,317,510 - 212,332,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,236,436 - 219,251,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,780,772 - 199,791,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1192,454,105 - 192,468,808 (-)NCBICelera
Cytogenetic Map1q41NCBI
Adam8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547710,895,446 - 10,907,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547710,894,288 - 10,906,961 (-)NCBIChiLan1.0ChiLan1.0
ADAM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,386,583 - 145,400,948 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,391,940 - 145,406,305 (-)NCBINHGRI_mPanPan1
PanPan1.110134,171,986 - 134,186,221 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,172,724 - 134,186,227 (-)Ensemblpanpan1.1panPan2
Adam8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,389,925 - 19,403,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,183,627 - 153,194,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,114,184 - 53,129,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,114,924 - 53,126,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,248,757 - 41,264,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,459,274 - 13,474,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAM8
169 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 4 1
Low 3 2 22 6 4 6 6 12 8 6 5
Below cutoff 2 3 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021319   ⟹   ENSCAFP00000019795
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000075199   ⟹   ENSCAFP00000046747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077463   ⟹   ENSCAFP00000058032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045492   ⟹   ENSCAFP00845035685
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045692   ⟹   ENSCAFP00845035855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,115 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045952   ⟹   ENSCAFP00845036074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,115 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046206   ⟹   ENSCAFP00845036283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,499,233 (-)Ensembl
RefSeq Acc Id: XM_038441010   ⟹   XP_038296938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBI
RefSeq Acc Id: XM_038460417   ⟹   XP_038316345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBI
RefSeq Acc Id: XM_038515588   ⟹   XP_038371516
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBI
RefSeq Acc Id: XM_038579192   ⟹   XP_038435120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBI
RefSeq Acc Id: XM_038643429   ⟹   XP_038499357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000019795   ⟸   ENSCAFT00000021319
RefSeq Acc Id: ENSCAFP00000058032   ⟸   ENSCAFT00000077463
RefSeq Acc Id: ENSCAFP00000046747   ⟸   ENSCAFT00000075199
RefSeq Acc Id: XP_038371516   ⟸   XM_038515588
RefSeq Acc Id: XP_038499357   ⟸   XM_038643429
RefSeq Acc Id: XP_038296938   ⟸   XM_038441010
- UniProtKB: A0A8C0TTL0 (UniProtKB/TrEMBL),   A0A8I3PVJ3 (UniProtKB/TrEMBL),   A0A8C0ML76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316345   ⟸   XM_038460417
- UniProtKB: A0A8P0P764 (UniProtKB/TrEMBL),   A0A8C0ML76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435120   ⟸   XM_038579192
- UniProtKB: A0A8C0ML76 (UniProtKB/TrEMBL),   A0A8P0P764 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845035685   ⟸   ENSCAFT00845045492
RefSeq Acc Id: ENSCAFP00845036074   ⟸   ENSCAFT00845045952
RefSeq Acc Id: ENSCAFP00845036283   ⟸   ENSCAFT00845046206
RefSeq Acc Id: ENSCAFP00845035855   ⟸   ENSCAFT00845045692
Protein Domains
Disintegrin   EGF-like   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013440 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007179 UniProtKB/TrEMBL
  ENSCAFG00040024708 UniProtKB/TrEMBL
  ENSCAFG00845025768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021319.5 UniProtKB/TrEMBL
  ENSCAFT00000075199.2 UniProtKB/TrEMBL
  ENSCAFT00000077463.2 UniProtKB/TrEMBL
  ENSCAFT00000100237.1 UniProtKB/TrEMBL
  ENSCAFT00000105805.1 UniProtKB/TrEMBL
  ENSCAFT00030013228.1 UniProtKB/TrEMBL
  ENSCAFT00040046021.1 UniProtKB/TrEMBL
  ENSCAFT00040046047.1 UniProtKB/TrEMBL
  ENSCAFT00040046080.1 UniProtKB/TrEMBL
  ENSCAFT00040046117.1 UniProtKB/TrEMBL
  ENSCAFT00040046163.1 UniProtKB/TrEMBL
  ENSCAFT00845045492 ENTREZGENE
  ENSCAFT00845045492.1 UniProtKB/TrEMBL
  ENSCAFT00845045692.1 UniProtKB/TrEMBL
  ENSCAFT00845045952.1 UniProtKB/TrEMBL
  ENSCAFT00845046206.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene ADAM8 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A8C0ML76 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TRL7_CANLF UniProtKB/TrEMBL
  A0A8C0TTF1_CANLF UniProtKB/TrEMBL
  A0A8C0TTL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TTN0_CANLF UniProtKB/TrEMBL
  A0A8C0TTQ1_CANLF UniProtKB/TrEMBL
  A0A8I3PNA4_CANLF UniProtKB/TrEMBL
  A0A8I3PRM5_CANLF UniProtKB/TrEMBL
  A0A8I3PSA5_CANLF UniProtKB/TrEMBL
  A0A8I3PVJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NWW6_CANLF UniProtKB/TrEMBL
  A0A8P0P764 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PFP7_CANLF UniProtKB/TrEMBL
  A0A8P0SIF9_CANLF UniProtKB/TrEMBL
  A0A8P0TRL3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37587 ENTREZGENE