CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4) - Rat Genome Database

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Gene: CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4) Canis lupus familiaris
Analyze
Symbol: CHCHD4
Name: coiled-coil-helix-coiled-coil-helix domain containing 4
RGD ID: 12376776
Description: ENCODES a protein that exhibits oxidoreductase activity (inferred); protein-disulfide reductase activity (inferred); INVOLVED IN 'de novo' post-translational protein folding (ortholog); cellular response to leukemia inhibitory factor (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; ASSOCIATED WITH 3p deletion syndrome (ortholog); FOUND IN mitochondrial intermembrane space (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitochondrial intermembrane space import and assembly protein 40
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,268,670 - 4,281,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,267,683 - 4,281,549 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,306,467 - 4,319,538 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,289,982 - 4,302,985 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,289,990 - 4,302,989 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1204,009,488 - 4,022,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,331,824 - 4,344,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,296,145 - 4,309,187 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CHCHD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,268,670 - 4,281,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,267,683 - 4,281,549 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,306,467 - 4,319,538 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,289,982 - 4,302,985 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,289,990 - 4,302,989 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1204,009,488 - 4,022,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,331,824 - 4,344,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,296,145 - 4,309,187 (-)NCBIUU_Cfam_GSD_1.0
CHCHD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38314,112,077 - 14,124,870 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl314,112,077 - 14,124,870 (-)EnsemblGRCh38hg38GRCh38
GRCh37314,153,577 - 14,166,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36314,128,578 - 14,141,372 (-)NCBINCBI36Build 36hg18NCBI36
Build 34314,128,583 - 14,141,323NCBI
Celera314,091,884 - 14,104,678 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef314,088,553 - 14,101,347 (-)NCBIHuRef
CHM1_1314,103,963 - 14,116,757 (-)NCBICHM1_1
T2T-CHM13v2.0314,114,022 - 14,126,815 (-)NCBIT2T-CHM13v2.0
Chchd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,441,258 - 91,450,405 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl691,439,154 - 91,450,528 (-)EnsemblGRCm39 Ensembl
GRCm38691,464,276 - 91,473,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,462,172 - 91,473,546 (-)EnsemblGRCm38mm10GRCm38
MGSCv37691,414,270 - 91,423,417 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36691,429,780 - 91,438,927 (-)NCBIMGSCv36mm8
Celera693,357,108 - 93,366,702 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.53NCBI
Chchd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,525,428 - 125,534,562 (-)NCBIGRCr8
mRatBN7.24123,968,264 - 123,977,398 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,968,265 - 123,977,414 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1227,987,570 - 227,988,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,434,271 - 129,443,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,208,699 - 125,217,814 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04123,833,253 - 123,842,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04123,108,924 - 123,118,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,108,925 - 123,118,186 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04187,427,514 - 187,436,776 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,647,269 - 125,656,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14125,891,750 - 125,900,884 (-)NCBI
Celera4112,887,725 - 112,896,859 (-)NCBICelera
Cytogenetic Map4q34NCBI
Chchd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542916,912,208 - 16,921,157 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542916,911,392 - 16,921,353 (-)NCBIChiLan1.0ChiLan1.0
CHCHD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,089,669 - 14,102,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1314,094,431 - 14,107,161 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0314,030,410 - 14,043,233 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1314,370,854 - 14,383,660 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,370,854 - 14,383,660 (-)Ensemblpanpan1.1panPan2
Chchd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494218,813,433 - 18,817,243 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493660293,123 - 95,810 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493660293,126 - 99,695 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHCHD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1370,417,326 - 70,428,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11370,417,326 - 70,428,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,875,900 - 77,887,497 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHCHD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12250,055,130 - 50,067,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2250,054,007 - 50,067,940 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041116,427,703 - 116,440,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chchd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248721,481,319 - 1,488,097 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248721,481,149 - 1,488,992 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CHCHD4
95 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 16 4 6 12 8 10 6
Low 1 6 6 2 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000007146   ⟹   ENSCAFP00000006615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl204,267,683 - 4,281,549 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042315   ⟹   ENSCAFP00845033178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl204,289,990 - 4,302,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042356   ⟹   ENSCAFP00845033205
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl204,289,990 - 4,295,379 (-)Ensembl
RefSeq Acc Id: XM_038426826   ⟹   XP_038282754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0204,289,982 - 4,302,985 (-)NCBI
RefSeq Acc Id: XM_038502622   ⟹   XP_038358550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1204,009,488 - 4,022,490 (-)NCBI
RefSeq Acc Id: XM_038565535   ⟹   XP_038421463
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0204,296,145 - 4,309,187 (-)NCBI
RefSeq Acc Id: XM_038629669   ⟹   XP_038485597
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0204,331,824 - 4,344,777 (-)NCBI
RefSeq Acc Id: XM_533726   ⟹   XP_533726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1204,268,670 - 4,281,624 (-)NCBI
Dog10K_Boxer_Tasha204,306,467 - 4,319,538 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_533726   ⟸   XM_533726
- UniProtKB: A0A8C0SXW5 (UniProtKB/TrEMBL),   A0A8C0QW12 (UniProtKB/TrEMBL),   A0A8I3PQ51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000006615   ⟸   ENSCAFT00000007146
RefSeq Acc Id: XP_038358550   ⟸   XM_038502622
RefSeq Acc Id: XP_038485597   ⟸   XM_038629669
RefSeq Acc Id: XP_038282754   ⟸   XM_038426826
- UniProtKB: A0A8C0SXW5 (UniProtKB/TrEMBL),   A0A8C0QW12 (UniProtKB/TrEMBL),   A0A8I3PQ51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421463   ⟸   XM_038565535
- UniProtKB: A0A8C0QW12 (UniProtKB/TrEMBL),   A0A8C0SXW5 (UniProtKB/TrEMBL),   A0A8I3PQ51 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033205   ⟸   ENSCAFT00845042356
RefSeq Acc Id: ENSCAFP00845033178   ⟸   ENSCAFT00845042315
Protein Domains
CHCH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004438 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017296 UniProtKB/TrEMBL
  ENSCAFG00040017111 UniProtKB/TrEMBL
  ENSCAFG00845023967 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007146.5 UniProtKB/TrEMBL
  ENSCAFT00030031875.1 UniProtKB/TrEMBL
  ENSCAFT00040031598.1 UniProtKB/TrEMBL
  ENSCAFT00845042315 ENTREZGENE
  ENSCAFT00845042315.1 UniProtKB/TrEMBL
  ENSCAFT00845042356.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2900 UniProtKB/TrEMBL
InterPro CHCH UniProtKB/TrEMBL
  CHCHD4 UniProtKB/TrEMBL
KEGG Report cfa:476520 UniProtKB/TrEMBL
NCBI Gene CHCHD4 ENTREZGENE
PANTHER AU015836 PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR21622 UniProtKB/TrEMBL
Pfam CHCH UniProtKB/TrEMBL
PROSITE CHCH UniProtKB/TrEMBL
UniProt A0A8C0QW12 ENTREZGENE
  A0A8C0SXW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PQ42_CANLF UniProtKB/TrEMBL
  A0A8I3PQ51 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39196 ENTREZGENE