APTX (aprataxin) - Rat Genome Database

Name: APTX
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: APTX (aprataxin) Canis lupus familiaris

Analyze

Symbol:

APTX

Name:

aprataxin

RGD ID:

12373167

Description:

ENCODES a protein that exhibits polynucleotide 3'-phosphatase activity (ortholog); INVOLVED IN DNA ligation (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); ataxia with oculomotor apraxia type 1 (ortholog); coenzyme Q10 deficiency disease (ortholog); FOUND IN chromatin (inferred); nucleolus (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

FHA-HIT; forkhead-associated domain histidine triad-like protein; LOC106559488; uncharacterized LOC106559488

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	APTX (aprataxin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Aptx (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Aptx (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aptx (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	APTX (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aptx (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	APTX (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	APTX (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aptx (aprataxin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	50,111,003 - 50,155,937 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	50,113,073 - 50,132,284 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	48,741,830 - 48,752,689 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	51,051,842 - 51,096,541 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	51,052,518 - 51,072,916 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	49,716,952 - 49,727,812 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	49,583,853 - 49,594,717 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	50,348,839 - 50,359,700 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

ataxia with oculomotor apraxia type 1 (ISO)

coenzyme Q10 deficiency disease (ISO)

distal arthrogryposis type 1A (ISO)

epilepsy (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

olivopontocerebellar atrophy (ISO)

primary ciliary dyskinesia (ISO)

primary coenzyme Q10 deficiency 1 (ISO)

spinocerebellar ataxia with axonal neuropathy 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA ligation (IEA,ISO)

DNA repair (IEA)

nucleobase-containing compound metabolic process (IEA)

regulation of protein stability (IEA)

single strand break repair (IBA,IEA)

Cellular Component

chromatin (IEA)

nucleolus (IEA)

nucleoplasm (IEA)

nucleus (IBA,IEA)

Molecular Function

catalytic activity (IEA)

chromatin binding (IEA)

damaged DNA binding (IEA)

DNA 5'-adenosine monophosphate hydrolase activity (IBA,IEA)

DNA binding (IEA)

DNA-3'-diphospho-5'-guanosine diphosphatase (IEA)

double-stranded DNA binding (IEA)

double-stranded RNA binding (IBA,IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

mismatched DNA binding (IBA,IEA)

phosphoglycolate phosphatase activity (IEA)

phosphoprotein binding (IEA)

polynucleotide 3'-phosphatase activity (ISO)

protein binding (ISO)

single-strand break-containing DNA binding (IBA,IEA)

single-stranded DNA binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

non-homologous end joining pathway of double-strand break repair (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

APTX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	50,111,003 - 50,155,937 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	50,113,073 - 50,132,284 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	48,741,830 - 48,752,689 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	51,051,842 - 51,096,541 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	51,052,518 - 51,072,916 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	49,716,952 - 49,727,812 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	49,583,853 - 49,594,717 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	50,348,839 - 50,359,700 (-)	NCBI		UU_Cfam_GSD_1.0

APTX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	32,972,616 - 33,025,120 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	32,886,601 - 33,025,130 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	32,972,614 - 33,025,118 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	32,962,608 - 32,991,626 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	32,903,909 - 32,932,925 (-)	NCBI		Celera
Cytogenetic Map	9	p21.1	NCBI
HuRef	9	32,930,986 - 32,960,001 (-)	NCBI		HuRef
CHM1_1	9	32,972,285 - 33,001,325 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	32,989,181 - 33,041,681 (-)	NCBI		T2T-CHM13v2.0

Aptx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	40,682,078 - 40,703,206 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	40,682,382 - 40,703,194 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	40,682,078 - 40,721,667 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	40,682,382 - 40,703,194 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	40,629,111 - 40,650,220 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	40,871,049 - 40,891,858 (-)	NCBI		MGSCv36	mm8
Celera	4	40,342,394 - 40,363,460 (-)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	20.46	NCBI

Aptx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	60,593,338 - 60,618,946 (-)	NCBI		GRCr8
mRatBN7.2	5	55,798,896 - 55,822,963 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	55,800,248 - 55,822,855 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	57,767,534 - 57,788,467 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	59,586,691 - 59,607,626 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	59,580,671 - 59,601,669 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	56,987,714 - 57,009,481 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	56,987,909 - 57,008,859 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,521,843 - 61,543,083 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	58,060,210 - 58,081,165 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	58,060,392 - 58,081,344 (-)	NCBI
Celera	5	54,414,271 - 54,435,214 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Aptx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	2,652,869 - 2,664,272 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	2,645,716 - 2,664,394 (+)	NCBI	ChiLan1.0	ChiLan1.0

APTX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	91,562,555 - 91,634,457 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	91,611,331 - 91,640,405 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	32,747,409 - 32,819,270 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	33,556,419 - 33,608,416 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	33,556,419 - 33,585,060 (-)	Ensembl	panpan1.1		panPan2

Aptx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	165,022,018 - 165,052,707 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	1,570,627 - 1,576,329 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	1,569,610 - 1,582,103 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APTX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	33,445,148 - 33,543,710 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	33,470,089 - 33,495,584 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	37,724,516 - 37,837,919 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APTX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	47,239,094 - 47,346,528 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	47,258,798 - 47,287,102 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	44,140,910 - 44,239,181 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aptx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	37,730,072 - 37,749,174 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	37,729,624 - 37,757,780 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in APTX
333 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			5				4			8	5
Low	5	5	17	6	6	6	2	6	12		5	6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005626389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014117653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014117654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014117656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY208843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000002845 ⟹ ENSCAFP00000002638

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	11	50,113,073 - 50,123,790 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000043374 ⟹ ENSCAFP00000041257

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	11	50,113,073 - 50,132,284 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000075258 ⟹ ENSCAFP00000051773

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	11	50,113,073 - 50,132,284 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000077001 ⟹ ENSCAFP00000055979

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	11	50,113,375 - 50,132,284 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845034894 ⟹ ENSCAFP00845027330

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	11	51,052,518 - 51,072,916 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845034979 ⟹ ENSCAFP00845027390

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	11	51,052,518 - 51,064,633 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845035067 ⟹ ENSCAFP00845027454

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	11	51,052,518 - 51,064,633 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845035108 ⟹ ENSCAFP00845027482

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	11	51,054,215 - 51,072,916 (-)	Ensembl

RefSeq Acc Id:

NM_001003355 ⟹ NP_001003355

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	11	50,113,075 - 50,123,935 (-)	NCBI
Dog10K_Boxer_Tasha	11	48,741,830 - 48,752,689 (-)	NCBI
ROS_Cfam_1.0	11	51,053,915 - 51,064,778 (-)	NCBI
UMICH_Zoey_3.1	11	49,716,952 - 49,727,812 (-)	NCBI
UNSW_CanFamBas_1.0	11	49,583,853 - 49,594,717 (-)	NCBI
UU_Cfam_GSD_1.0	11	50,348,839 - 50,359,700 (-)	NCBI

Sequence:

show sequence

GTGAGAAAATTGAGACCTAAGTGAAGTCATCTTGGCCGCAAGAGTAATGATGCGGATGTGCTGG
TTGGTGAGACAGGATAACCAGCACCAACGAATCAAACTTCCACATTTGGAAGCAGTCATGGTTG
GGCGTGGCCCAGAGACCAAGATCATTGACAAGAAGTGTTCTCGACAGCAAGTACAGTTGAAAGC
AGAATGTAACAAAGGATATGTCAAGGTAAAGCAGGTAGGGGTCAATCCCACCAGCATTGACTCA
GTCATAATTGGGAAGGACCAAGAGGCGAAGCTGCAGCCTGGCCAGGTTCTCCACATGGTGAATG
AACTTTATCCATATATTGTAGAATTTGAGGAAGAGGCAGAGAGCCCTGGCCTGGAAACACACAG
GAAGAGAAAGAGGTCAGGCAACAGTGATTCTATAGAAAGGGATGCTGCCCAGGAAGCTGAGTCC
AGCACAGGACTGGAACCTGGGAGTGACTCTAGCCAATGCTCTGTGCCCCTCAACAAGGGGAAGG
ATGCACCTACCAAAAAGGAATCATTGGGCCACTGGAGTCAAGGCTTGAAAATTTCTATGCAGGA
TCCCAAAATGCAGGTTTACAAAGATGAGCAGGTGGTGGTGATTAAGGATAAATACCCCAAGGCT
CGTTACCACTGGCTGGTCTTACCATGGGCTTCCGTTTCCAGTCTGAAGGCTGTGACCGGGGAAC
ACCTTGAGCTCCTCAAACACATGCACACTGTGGGGGAAAAGATGATTGCAGATTTTGCTGGGTC
CAGCAAACTCCGCTTCCGATTGGGTTACCATGCCATTCCCAGCATGAGCCATGTACACCTTCAT
GTGATCAGCCAGGATTTTGATTCTCCTTGCCTTAAAAACAAAAAACATTGGAATTCTTTCAATA
CAGAATACTTCCTAGAATCACAAGCTGTGATAGAGATGGTACAGCACGCTGGCAGAGTGAGTGT
CCGAGATGGGATGCCTGAGCTCTTGAAGCTGCCTCTCCGTTGTCACGAGTGCCAGCAGCTGCTG
CCTTCCATTCCTCAGCTGAAAGAGCATCTCAGGAGGCACTGGCCAAAATGATTCTTTGGAGCCT
GAACTTTTGCAGCAGGTGTGGCTGATTGTTTAGAAGGAATTCCTGGCACCTGTTCTGGATTGCT
TGTGAACTTTTATTTCTTGAATTAAAACATGCAGCCTTCTAAAAAA

hide sequence

RefSeq Acc Id:

XM_038680912 ⟹ XP_038536840

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,064,811 (-)	NCBI

RefSeq Acc Id:

XM_038680914 ⟹ XP_038536842

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,950 (-)	NCBI

RefSeq Acc Id:

XM_038680915 ⟹ XP_038536843

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,856 (-)	NCBI

RefSeq Acc Id:

XM_038680916 ⟹ XP_038536844

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,976 (-)	NCBI

RefSeq Acc Id:

XM_038680917 ⟹ XP_038536845

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,934 (-)	NCBI

RefSeq Acc Id:

XM_038680918 ⟹ XP_038536846

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,950 (-)	NCBI

RefSeq Acc Id:

XM_038680919 ⟹ XP_038536847

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,934 (-)	NCBI

RefSeq Acc Id:

XM_038680920 ⟹ XP_038536848

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,909 (-)	NCBI

RefSeq Acc Id:

XM_038680921 ⟹ XP_038536849

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,096,541 (-)	NCBI

RefSeq Acc Id:

XM_038680922 ⟹ XP_038536850

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,598 (-)	NCBI

RefSeq Acc Id:

XM_038680923 ⟹ XP_038536851

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,973 (-)	NCBI

RefSeq Acc Id:

XM_038680924 ⟹ XP_038536852

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,934 (-)	NCBI

RefSeq Acc Id:

XM_038680925 ⟹ XP_038536853

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,934 (-)	NCBI

RefSeq Acc Id:

XM_038680926 ⟹ XP_038536854

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,988 (-)	NCBI

RefSeq Acc Id:

XM_038680927 ⟹ XP_038536855

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,857 (-)	NCBI

RefSeq Acc Id:

XM_038680928 ⟹ XP_038536856

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,072,737 (-)	NCBI

RefSeq Acc Id:

XM_038680929 ⟹ XP_038536857

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	51,051,842 - 51,064,640 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001003355	(Get FASTA)	NCBI Sequence Viewer
	XP_038536840	(Get FASTA)	NCBI Sequence Viewer
	XP_038536842	(Get FASTA)	NCBI Sequence Viewer
	XP_038536843	(Get FASTA)	NCBI Sequence Viewer
	XP_038536844	(Get FASTA)	NCBI Sequence Viewer
	XP_038536845	(Get FASTA)	NCBI Sequence Viewer
	XP_038536846	(Get FASTA)	NCBI Sequence Viewer
	XP_038536847	(Get FASTA)	NCBI Sequence Viewer
	XP_038536848	(Get FASTA)	NCBI Sequence Viewer
	XP_038536849	(Get FASTA)	NCBI Sequence Viewer
	XP_038536850	(Get FASTA)	NCBI Sequence Viewer
	XP_038536851	(Get FASTA)	NCBI Sequence Viewer
	XP_038536852	(Get FASTA)	NCBI Sequence Viewer
	XP_038536853	(Get FASTA)	NCBI Sequence Viewer
	XP_038536854	(Get FASTA)	NCBI Sequence Viewer
	XP_038536855	(Get FASTA)	NCBI Sequence Viewer
	XP_038536856	(Get FASTA)	NCBI Sequence Viewer
	XP_038536857	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP86333	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000002638.4
	ENSCAFP00000041257.3
	ENSCAFP00000051773.2
	ENSCAFP00000055979.2
	ENSCAFP00030012379.1
	ENSCAFP00030012414.1
	ENSCAFP00030012477.1
	ENSCAFP00030012505.1
	ENSCAFP00040010459.1
	ENSCAFP00040010502.1
	ENSCAFP00040010528.1
	ENSCAFP00040010547.1
	ENSCAFP00845027330
	ENSCAFP00845027330.1
	ENSCAFP00845027390
	ENSCAFP00845027390.1
	ENSCAFP00845027454
	ENSCAFP00845027454.1
	ENSCAFP00845027482
	ENSCAFP00845027482.1
GenBank Protein	P61797	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001003355 ⟸ NM_001003355

- UniProtKB:

P61797 (UniProtKB/Swiss-Prot), A0A8C0QNI5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMRMCWLVRQDNQHQRIKLPHLEAVMVGRGPETKIIDKKCSRQQVQLKAECNKGYVKVKQVGVN
PTSIDSVIIGKDQEAKLQPGQVLHMVNELYPYIVEFEEEAESPGLETHRKRKRSGNSDSIERDA
AQEAESSTGLEPGSDSSQCSVPLNKGKDAPTKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIK
DKYPKARYHWLVLPWASVSSLKAVTGEHLELLKHMHTVGEKMIADFAGSSKLRFRLGYHAIPSM
SHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQHAGRVSVRDGMPELLKLPLRCH
ECQQLLPSIPQLKEHLRRHWPK

hide sequence

RefSeq Acc Id:

ENSCAFP00000055979 ⟸ ENSCAFT00000077001

RefSeq Acc Id:

ENSCAFP00000041257 ⟸ ENSCAFT00000043374

RefSeq Acc Id:

ENSCAFP00000051773 ⟸ ENSCAFT00000075258

RefSeq Acc Id:

ENSCAFP00000002638 ⟸ ENSCAFT00000002845

RefSeq Acc Id:	XP_038536849 ⟸ XM_038680921
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536854 ⟸ XM_038680926
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536844 ⟸ XM_038680916
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536851 ⟸ XM_038680923
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536842 ⟸ XM_038680914
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536846 ⟸ XM_038680918
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536853 ⟸ XM_038680925
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536845 ⟸ XM_038680917
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536852 ⟸ XM_038680924
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536847 ⟸ XM_038680919
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536848 ⟸ XM_038680920
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536855 ⟸ XM_038680927
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536843 ⟸ XM_038680915
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536856 ⟸ XM_038680928
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0RZE8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536850 ⟸ XM_038680922
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KSH5 (UniProtKB/TrEMBL), A0A8I3P5N1 (UniProtKB/TrEMBL), A0A8P0P1I1 (UniProtKB/TrEMBL), A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536840 ⟸ XM_038680912
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0QNI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038536857 ⟸ XM_038680929
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I3PAL3 (UniProtKB/TrEMBL), A0A8P0SV65 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845027390 ⟸ ENSCAFT00845034979

RefSeq Acc Id:

ENSCAFP00845027482 ⟸ ENSCAFT00845035108

RefSeq Acc Id:

ENSCAFP00845027330 ⟸ ENSCAFT00845034894

RefSeq Acc Id:

ENSCAFP00845027454 ⟸ ENSCAFT00845035067

Protein Domains

FHA-like HIT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001812	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030007183	UniProtKB/TrEMBL
	ENSCAFG00040006133	UniProtKB/TrEMBL
	ENSCAFG00845019738	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000002845.6	UniProtKB/TrEMBL
	ENSCAFT00000043374.3	UniProtKB/TrEMBL
	ENSCAFT00000075258.2	UniProtKB/TrEMBL
	ENSCAFT00000077001.2	UniProtKB/TrEMBL
	ENSCAFT00030014190.1	UniProtKB/TrEMBL
	ENSCAFT00030014239.1	UniProtKB/TrEMBL
	ENSCAFT00030014311.1	UniProtKB/TrEMBL
	ENSCAFT00030014340.1	UniProtKB/TrEMBL
	ENSCAFT00040012066.1	UniProtKB/TrEMBL
	ENSCAFT00040012115.1	UniProtKB/TrEMBL
	ENSCAFT00040012147.1	UniProtKB/TrEMBL
	ENSCAFT00040012169.1	UniProtKB/TrEMBL
	ENSCAFT00845034894	ENTREZGENE
	ENSCAFT00845034894.1	UniProtKB/TrEMBL
	ENSCAFT00845034979	ENTREZGENE
	ENSCAFT00845034979.1	UniProtKB/TrEMBL
	ENSCAFT00845035067	ENTREZGENE
	ENSCAFT00845035067.1	UniProtKB/TrEMBL
	ENSCAFT00845035108	ENTREZGENE
	ENSCAFT00845035108.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.200.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.428.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	FHA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FHA_APTX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Histidine_triad_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HIT-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HIT-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SMAD_FHA_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf-C2HE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:442943	UniProtKB/Swiss-Prot
NCBI Gene	APTX	ENTREZGENE
PANTHER	APRATAXIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12486:SF4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DcpS_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FHA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C2HE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HIT_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HIT_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49879	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54197	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0KSH5	ENTREZGENE
	A0A8C0MIX8_CANLF	UniProtKB/TrEMBL
	A0A8C0MPJ5_CANLF	UniProtKB/TrEMBL
	A0A8C0QNI5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RZ55_CANLF	UniProtKB/TrEMBL
	A0A8C0RZE8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P5N1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P5S9_CANLF	UniProtKB/TrEMBL
	A0A8I3PAL3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S1E1_CANLF	UniProtKB/TrEMBL
	A0A8P0P1I1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0P5A0_CANLF	UniProtKB/TrEMBL
	A0A8P0SV65	ENTREZGENE, UniProtKB/TrEMBL
	APTX_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID	VGNC:38015	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-11-21	APTX	aprataxin	LOC106559488	uncharacterized LOC106559488	Data merged from RGD:12082722	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations