BORA (BORA aurora kinase A activator) - Rat Genome Database

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Gene: BORA (BORA aurora kinase A activator) Canis lupus familiaris
Analyze
Symbol: BORA
Name: BORA aurora kinase A activator
RGD ID: 12369963
Description: ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN regulation of mitotic nuclear division (inferred); regulation of mitotic spindle organization (inferred); regulation of protein localization (inferred); ASSOCIATED WITH chromosome 13q14 deletion syndrome (ortholog); FOUND IN cytoplasm (inferred); meiotic spindle (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bora, aurora kinase A activator; protein aurora borealis
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12226,880,351 - 26,906,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2226,879,933 - 26,906,278 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2226,735,652 - 26,762,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,211,177 - 27,237,646 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,211,198 - 27,237,661 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12226,873,278 - 26,899,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02226,912,735 - 26,939,190 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02226,984,118 - 27,010,590 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
meiotic spindle  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
BORA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12226,880,351 - 26,906,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2226,879,933 - 26,906,278 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2226,735,652 - 26,762,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,211,177 - 27,237,646 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,211,198 - 27,237,661 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12226,873,278 - 26,899,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02226,912,735 - 26,939,190 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02226,984,118 - 27,010,590 (+)NCBIUU_Cfam_GSD_1.0
BORA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381372,727,923 - 72,756,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1372,727,749 - 72,756,198 (+)EnsemblGRCh38hg38GRCh38
GRCh371373,302,061 - 73,330,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,200,043 - 72,228,329 (+)NCBINCBI36Build 36hg18NCBI36
Celera1354,200,530 - 54,228,790 (+)NCBICelera
Cytogenetic Map13q21.33NCBI
HuRef1353,999,585 - 54,027,635 (+)NCBIHuRef
CHM1_11373,269,762 - 73,298,008 (+)NCBICHM1_1
T2T-CHM13v2.01371,949,448 - 71,977,692 (+)NCBIT2T-CHM13v2.0
Bora
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,283,880 - 99,311,976 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,283,658 - 99,311,976 (+)EnsemblGRCm39 Ensembl
GRCm381499,046,377 - 99,074,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,046,222 - 99,074,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv371499,445,596 - 99,473,326 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361497,929,511 - 97,957,241 (+)NCBIMGSCv36mm8
Celera1497,720,752 - 97,749,866 (+)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.23NCBI
Bora
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,205,467 - 82,243,499 (+)NCBIGRCr8
mRatBN7.21575,797,624 - 75,835,599 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,797,891 - 75,821,322 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1579,780,918 - 79,805,541 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,857,536 - 80,882,159 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,805,079 - 77,829,702 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,442,217 - 83,463,737 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,442,144 - 83,463,717 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01586,953,333 - 86,975,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41582,829,209 - 82,852,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11582,844,988 - 82,867,842 (+)NCBI
Celera1575,035,699 - 75,061,119 (+)NCBICelera
Cytogenetic Map15q21NCBI
Bora
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,924,533 - 33,946,346 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,923,496 - 33,946,113 (-)NCBIChiLan1.0ChiLan1.0
BORA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,307,848 - 74,337,454 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11372,899,069 - 72,927,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01353,956,913 - 53,985,355 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11372,733,006 - 72,761,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1372,733,006 - 72,761,432 (+)Ensemblpanpan1.1panPan2
Bora
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,690,249 - 132,717,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365118,107,756 - 8,134,683 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365118,107,476 - 8,134,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BORA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,018,333 - 45,045,126 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,017,651 - 45,045,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,564,863 - 49,592,665 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BORA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1351,860,304 - 51,888,410 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl351,860,405 - 51,887,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660467,954,590 - 7,982,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bora
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,789,093 - 27,815,445 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475127,788,754 - 27,814,986 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BORA
226 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 5 5 22 6 6 6 6 4 12 10 6
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008007   ⟹   ENSCAFP00000007414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2226,879,933 - 26,906,278 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000039235   ⟹   ENSCAFP00000035056
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2226,879,933 - 26,904,770 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000072244   ⟹   ENSCAFP00000055330
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2226,879,933 - 26,899,707 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077869   ⟹   ENSCAFP00000049778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2226,879,933 - 26,902,269 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089632   ⟹   ENSCAFP00000063081
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2226,880,426 - 26,884,565 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845038802   ⟹   ENSCAFP00845030387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2227,211,198 - 27,237,661 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845038917   ⟹   ENSCAFP00845030476
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2227,211,198 - 27,236,153 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039028   ⟹   ENSCAFP00845030571
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2227,211,198 - 27,231,085 (+)Ensembl
RefSeq Acc Id: XM_038431152   ⟹   XP_038287080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02227,211,177 - 27,237,646 (+)NCBI
RefSeq Acc Id: XM_038456770   ⟹   XP_038312698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2226,735,652 - 26,762,114 (+)NCBI
RefSeq Acc Id: XM_038506536   ⟹   XP_038362464
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12226,873,278 - 26,899,746 (+)NCBI
RefSeq Acc Id: XM_038569729   ⟹   XP_038425657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02226,984,118 - 27,010,590 (+)NCBI
RefSeq Acc Id: XM_038633897   ⟹   XP_038489825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02226,912,735 - 26,939,190 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000035056   ⟸   ENSCAFT00000039235
RefSeq Acc Id: ENSCAFP00000049778   ⟸   ENSCAFT00000077869
RefSeq Acc Id: ENSCAFP00000055330   ⟸   ENSCAFT00000072244
RefSeq Acc Id: ENSCAFP00000007414   ⟸   ENSCAFT00000008007
RefSeq Acc Id: ENSCAFP00000063081   ⟸   ENSCAFT00000089632
RefSeq Acc Id: XP_038362464   ⟸   XM_038506536
RefSeq Acc Id: XP_038489825   ⟸   XM_038633897
RefSeq Acc Id: XP_038287080   ⟸   XM_038431152
- UniProtKB: A0A8C0LJV9 (UniProtKB/TrEMBL),   A0A8C0RZI2 (UniProtKB/TrEMBL),   A0A8I3PER3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038312698   ⟸   XM_038456770
- UniProtKB: A0A8C0LJV9 (UniProtKB/TrEMBL),   A0A8C0RZI2 (UniProtKB/TrEMBL),   A0A8I3PER3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038425657   ⟸   XM_038569729
- UniProtKB: A0A8C0LJV9 (UniProtKB/TrEMBL),   A0A8C0RZI2 (UniProtKB/TrEMBL),   A0A8I3PER3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845030571   ⟸   ENSCAFT00845039028
RefSeq Acc Id: ENSCAFP00845030476   ⟸   ENSCAFT00845038917
RefSeq Acc Id: ENSCAFP00845030387   ⟸   ENSCAFT00845038802

Promoters
RGD ID:13687321
Promoter ID:EPDNEW_C5389
Type:single initiation site
Name:BORA_1
Description:bora, aurora kinase A activator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12226,880,399 - 26,880,459EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004981 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011164 UniProtKB/TrEMBL
  ENSCAFG00040006630 UniProtKB/TrEMBL
  ENSCAFG00845021990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008007.5 UniProtKB/TrEMBL
  ENSCAFT00000039235.5 UniProtKB/TrEMBL
  ENSCAFT00000072244.2 UniProtKB/TrEMBL
  ENSCAFT00030020874.1 UniProtKB/TrEMBL
  ENSCAFT00040012365.1 UniProtKB/TrEMBL
  ENSCAFT00040012422.1 UniProtKB/TrEMBL
  ENSCAFT00040012468.1 UniProtKB/TrEMBL
  ENSCAFT00845038802 ENTREZGENE
  ENSCAFT00845038802.1 UniProtKB/TrEMBL
  ENSCAFT00845038917.1 UniProtKB/TrEMBL
  ENSCAFT00845039028.1 UniProtKB/TrEMBL
InterPro Aurora_borealis_protein UniProtKB/TrEMBL
NCBI Gene BORA ENTREZGENE
PANTHER PROTEIN AURORA BOREALIS UniProtKB/TrEMBL
  PTHR14728 UniProtKB/TrEMBL
Pfam BORA_N UniProtKB/TrEMBL
PRINTS AURORABORA UniProtKB/TrEMBL
UniProt A0A8C0LJV9 ENTREZGENE
  A0A8C0QHA1_CANLF UniProtKB/TrEMBL
  A0A8C0RZI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RZJ0_CANLF UniProtKB/TrEMBL
  A0A8I3PAE5_CANLF UniProtKB/TrEMBL
  A0A8I3PER3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PIT4_CANLF UniProtKB/TrEMBL
  A0A8P0T7J3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38499 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 BORA  BORA aurora kinase A activator    bora, aurora kinase A activator  Symbol and/or name change 5135510 APPROVED