VNN1 (vanin 1) - Rat Genome Database

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Gene: VNN1 (vanin 1) Canis lupus familiaris
Analyze
Symbol: VNN1
Name: vanin 1
RGD ID: 12367154
Description: ENCODES a protein that exhibits pantetheine hydrolase activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); cell-cell adhesion (ortholog); chronic inflammatory response (ortholog); PARTICIPATES IN pantothenic acid metabolic pathway; ASSOCIATED WITH atopic dermatitis (ortholog); celiac disease (ortholog); Dyslipidemias (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC102155259; pantetheinase; pantetheinase-like; pantetheine hydrolase; TIFF66; vascular non-inflammatory molecule 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,678,039 - 25,704,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,678,042 - 25,696,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,742,992 - 26,770,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,767,887 - 25,802,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,767,890 - 25,796,358 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,690,559 - 25,711,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,596,017 - 25,624,588 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,852,617 - 25,901,434 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
VNN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,678,039 - 25,704,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,678,042 - 25,696,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,742,992 - 26,770,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,767,887 - 25,802,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,767,890 - 25,796,358 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,690,559 - 25,711,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,596,017 - 25,624,588 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,852,617 - 25,901,434 (-)NCBIUU_Cfam_GSD_1.0
VNN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386132,680,849 - 132,714,055 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6132,680,849 - 132,714,055 (-)EnsemblGRCh38hg38GRCh38
GRCh376133,001,988 - 133,035,194 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366133,044,422 - 133,076,881 (-)NCBINCBI36Build 36hg18NCBI36
Build 346133,044,422 - 133,076,881NCBI
Celera6133,748,822 - 133,782,014 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6130,576,916 - 130,610,106 (-)NCBIHuRef
CHM1_16133,265,672 - 133,298,869 (-)NCBICHM1_1
T2T-CHM13v2.06133,875,818 - 133,909,022 (-)NCBIT2T-CHM13v2.0
Vnn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391023,770,586 - 23,781,242 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1023,770,586 - 23,781,241 (+)EnsemblGRCm39 Ensembl
GRCm381023,894,688 - 23,905,344 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1023,894,688 - 23,905,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv371023,614,494 - 23,625,149 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361023,573,041 - 23,594,755 (+)NCBIMGSCv36mm8
Celera1024,828,202 - 24,838,840 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.33NCBI
Vnn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,356,324 - 23,366,629 (-)NCBIGRCr8
mRatBN7.2121,537,084 - 21,547,395 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,537,094 - 21,547,395 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,316,351 - 21,326,676 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,316,396 - 27,326,721 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,513,723 - 21,524,007 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,614,832 - 22,625,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,614,783 - 22,625,204 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,089,365 - 24,099,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,087,290 - 22,097,592 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,090,508 - 22,100,537 (-)NCBI
Celera120,280,201 - 20,290,503 (-)NCBICelera
Cytogenetic Map1p12NCBI
Vnn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543613,238,603 - 13,259,577 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543613,238,307 - 13,266,800 (-)NCBIChiLan1.0ChiLan1.0
VNN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25152,665,525 - 152,697,484 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16150,572,617 - 150,604,502 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06130,459,268 - 130,491,167 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16134,566,110 - 134,598,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6134,566,117 - 134,598,784 (-)Ensemblpanpan1.1panPan2
Vnn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,920,545 - 120,951,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936560701,892 - 729,526 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936560701,857 - 729,516 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VNN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,000,255 - 31,024,505 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,003,338 - 31,023,731 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2134,520,052 - 34,544,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Vnn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247536,867,953 - 6,892,186 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247536,869,269 - 6,892,217 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VNN1
345 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 15 6 6 6 6 1 10 6
Low 7 6 11 1
Below cutoff 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005352846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005352847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005352848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005352849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY514785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000297   ⟹   ENSCAFP00000000268
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl125,678,042 - 25,696,807 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000036358   ⟹   ENSCAFP00000031722
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl125,678,042 - 25,696,807 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008456   ⟹   ENSCAFP00845006661
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl125,767,890 - 25,796,358 (-)Ensembl
RefSeq Acc Id: NM_001003372   ⟹   NP_001003372
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1125,678,039 - 25,704,579 (-)NCBI
Dog10K_Boxer_Tasha126,742,992 - 26,770,993 (+)NCBI
ROS_Cfam_1.0125,767,888 - 25,796,324 (-)NCBI
UMICH_Zoey_3.1125,690,559 - 25,711,049 (-)NCBI
UNSW_CanFamBas_1.0125,596,017 - 25,624,588 (-)NCBI
UU_Cfam_GSD_1.0125,852,617 - 25,901,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038653455   ⟹   XP_038509383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,756 (-)NCBI
RefSeq Acc Id: XM_038653456   ⟹   XP_038509384
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,756 (-)NCBI
RefSeq Acc Id: XM_038653457   ⟹   XP_038509385
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,756 (-)NCBI
RefSeq Acc Id: XM_038653458   ⟹   XP_038509386
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,755 (-)NCBI
RefSeq Acc Id: XM_038653459   ⟹   XP_038509387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,755 (-)NCBI
RefSeq Acc Id: XM_038653460   ⟹   XP_038509388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,755 (-)NCBI
RefSeq Acc Id: XM_038653461   ⟹   XP_038509389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,802,755 (-)NCBI
RefSeq Acc Id: XM_038653462   ⟹   XP_038509390
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,792,751 (-)NCBI
RefSeq Acc Id: XM_038653463   ⟹   XP_038509391
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,767,887 - 25,792,620 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003372   ⟸   NM_001003372
- Peptide Label: precursor
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000268   ⟸   ENSCAFT00000000297
RefSeq Acc Id: ENSCAFP00000031722   ⟸   ENSCAFT00000036358
RefSeq Acc Id: XP_038509385   ⟸   XM_038653457
- Peptide Label: isoform X3
- UniProtKB: A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509384   ⟸   XM_038653456
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509383   ⟸   XM_038653455
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S662 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509389   ⟸   XM_038653461
- Peptide Label: isoform X4
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509386   ⟸   XM_038653458
- Peptide Label: isoform X4
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509387   ⟸   XM_038653459
- Peptide Label: isoform X4
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509388   ⟸   XM_038653460
- Peptide Label: isoform X4
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509390   ⟸   XM_038653462
- Peptide Label: isoform X4
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509391   ⟸   XM_038653463
- Peptide Label: isoform X4
- UniProtKB: Q9TSX8 (UniProtKB/Swiss-Prot),   A0A8C0L6M2 (UniProtKB/TrEMBL),   A0A8I3MVQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845006661   ⟸   ENSCAFT00845008456
Protein Domains
CN hydrolase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023591 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00805000995 UniProtKB/Swiss-Prot
  ENSCAFG00845004723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFG00845004762 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000297.6 UniProtKB/TrEMBL
  ENSCAFT00000036358.4 UniProtKB/TrEMBL
  ENSCAFT00805001822 UniProtKB/Swiss-Prot
  ENSCAFT00805001828 UniProtKB/Swiss-Prot
  ENSCAFT00845008456 ENTREZGENE
  ENSCAFT00845008456.1 UniProtKB/Swiss-Prot
  ENSCAFT00845008537.1 UniProtKB/Swiss-Prot
  ENSCAFT00845008546.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Biotinidase-like_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotinidase/VNN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-N_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-N_Hydrolase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vanin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:442973 UniProtKB/Swiss-Prot
NCBI Gene VNN1 ENTREZGENE
PANTHER PANTETHEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CN_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vanin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Biotinidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CN_HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0L6M2 ENTREZGENE
  A0A8I3MVQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NLW8_CANLF UniProtKB/TrEMBL
  A0A8P0S662 ENTREZGENE, UniProtKB/TrEMBL
  Q6JDF6_CANLF UniProtKB/TrEMBL
  Q9TSX8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 VNN1  vanin 1  LOC102155259  pantetheinase-like  Data merged from RGD:12181608 737654 PROVISIONAL