BCL2L12 (BCL2 like 12) - Rat Genome Database

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Gene: BCL2L12 (BCL2 like 12) Canis lupus familiaris
Analyze
Symbol: BCL2L12
Name: BCL2 like 12
RGD ID: 12366984
Description: ENCODES a protein that exhibits p53 binding (inferred); INVOLVED IN negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 12 (ortholog); genetic disease (ortholog); melanoma (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl-2-like protein 12; BCL2-like 12 (proline rich)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,865,346 - 106,873,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,449,262 - 106,456,965 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,386,929 - 107,394,627 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,387,031 - 107,393,829 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,059,171 - 107,066,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,701,245 - 106,708,951 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,542,142 - 107,550,072 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
BCL2L12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,865,346 - 106,873,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,449,262 - 106,456,965 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,386,929 - 107,394,627 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,387,031 - 107,393,829 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,059,171 - 107,066,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,701,245 - 106,708,951 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,542,142 - 107,550,072 (-)NCBIUU_Cfam_GSD_1.0
BCL2L12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,665,142 - 49,673,916 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,665,142 - 49,673,916 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,168,399 - 50,177,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,860,211 - 54,868,985 (+)NCBINCBI36Build 36hg18NCBI36
Celera1947,037,733 - 47,046,507 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,545,171 - 46,553,945 (+)NCBIHuRef
CHM1_11950,170,188 - 50,178,962 (+)NCBICHM1_1
T2T-CHM13v2.01952,665,212 - 52,673,986 (+)NCBIT2T-CHM13v2.0
Bcl2l12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,640,646 - 44,647,011 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,640,646 - 44,648,136 (-)EnsemblGRCm39 Ensembl
GRCm38744,991,222 - 44,997,638 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,991,222 - 44,998,712 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,246,592 - 52,252,949 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,859,267 - 44,865,621 (-)NCBIMGSCv36mm8
Celera740,442,782 - 40,449,139 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.07NCBI
Bcl2l12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,608,753 - 104,617,472 (-)NCBIGRCr8
mRatBN7.2195,472,272 - 95,480,991 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,472,272 - 95,480,991 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,857,672 - 100,866,391 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,330,338 - 109,339,057 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,620,731 - 102,629,450 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,984,550 - 100,993,269 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,984,550 - 100,993,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,048,990 - 102,057,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,462,429 - 95,471,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,541,167 - 95,547,485 (-)NCBI
Celera189,733,600 - 89,742,319 (-)NCBICelera
Cytogenetic Map1q22NCBI
Bcl2l12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,217,809 - 1,224,875 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,217,797 - 1,224,875 (-)NCBIChiLan1.0ChiLan1.0
BCL2L12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,783,098 - 55,791,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,703,837 - 57,711,944 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,679,749 - 46,688,539 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,599,170 - 55,607,901 (+)NCBIpanpan1.1PanPan1.1panPan2
Bcl2l12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,864,314 - 21,870,478 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,482,595 - 3,488,663 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,482,562 - 3,488,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,707,237 - 54,715,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,706,453 - 54,715,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,436,162 - 50,443,172 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,841,391 - 42,849,207 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,785,894 - 22,793,788 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2l12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,605,821 - 4,611,366 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,605,765 - 4,611,392 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BCL2L12
75 total Variants

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022423771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038671453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038671517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00845040942   ⟹   ENSCAFP00845032070
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1107,387,031 - 107,393,829 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041000   ⟹   ENSCAFP00845032121
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1107,387,060 - 107,393,829 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041051   ⟹   ENSCAFP00845032166
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1107,387,060 - 107,393,829 (-)Ensembl
RefSeq Acc Id: XM_022423771   ⟹   XP_022279479
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11106,865,346 - 106,873,329 (-)NCBI
Dog10K_Boxer_Tasha1106,449,262 - 106,456,964 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038467514   ⟹   XP_038323442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,059,171 - 107,066,862 (-)NCBI
RefSeq Acc Id: XM_038467515   ⟹   XP_038323443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,059,171 - 107,066,863 (-)NCBI
RefSeq Acc Id: XM_038467516   ⟹   XP_038323444
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,059,171 - 107,066,863 (-)NCBI
RefSeq Acc Id: XM_038528220   ⟹   XP_038384148
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01107,542,142 - 107,550,071 (-)NCBI
RefSeq Acc Id: XM_038528221   ⟹   XP_038384149
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01107,542,142 - 107,550,072 (-)NCBI
RefSeq Acc Id: XM_038528222   ⟹   XP_038384150
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01107,542,142 - 107,550,072 (-)NCBI
RefSeq Acc Id: XM_038592514   ⟹   XP_038448442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01106,701,245 - 106,708,950 (-)NCBI
RefSeq Acc Id: XM_038592515   ⟹   XP_038448443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01106,701,245 - 106,708,951 (-)NCBI
RefSeq Acc Id: XM_038592516   ⟹   XP_038448444
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01106,701,245 - 106,708,951 (-)NCBI
RefSeq Acc Id: XM_038656305   ⟹   XP_038512233
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,386,929 - 107,394,626 (-)NCBI
RefSeq Acc Id: XM_038656306   ⟹   XP_038512234
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,386,929 - 107,394,627 (-)NCBI
RefSeq Acc Id: XM_038656307   ⟹   XP_038512235
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,386,929 - 107,394,627 (-)NCBI
RefSeq Acc Id: XM_038671453   ⟹   XP_038527381
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1106,449,262 - 106,456,965 (-)NCBI
RefSeq Acc Id: XM_038671517   ⟹   XP_038527445
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1106,449,262 - 106,456,965 (-)NCBI
RefSeq Acc Id: XP_022279479   ⟸   XM_022423771
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S9A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038323443   ⟸   XM_038467515
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038323444   ⟸   XM_038467516
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038323442   ⟸   XM_038467514
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038448443   ⟸   XM_038592515
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038448444   ⟸   XM_038592516
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038448442   ⟸   XM_038592514
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512234   ⟸   XM_038656306
- Peptide Label: isoform X2
- UniProtKB: A0A8P0TUK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512235   ⟸   XM_038656307
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038512233   ⟸   XM_038656305
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S9A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038527381   ⟸   XM_038671453
- Peptide Label: isoform X2
- UniProtKB: A0A8P0TUK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038527445   ⟸   XM_038671517
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038384149   ⟸   XM_038528221
- Peptide Label: isoform X2
- UniProtKB: A0A8P0TUK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384150   ⟸   XM_038528222
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038384148   ⟸   XM_038528220
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S9A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032121   ⟸   ENSCAFT00845041000
RefSeq Acc Id: ENSCAFP00845032166   ⟸   ENSCAFT00845041051
RefSeq Acc Id: ENSCAFP00845032070   ⟸   ENSCAFT00845040942


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000053130 UniProtKB/TrEMBL
  ENSCAFG00030000643 UniProtKB/TrEMBL
  ENSCAFG00040016739 UniProtKB/TrEMBL
  ENSCAFG00845023183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005781.5 UniProtKB/TrEMBL
  ENSCAFT00000059726.2 UniProtKB/TrEMBL
  ENSCAFT00000094740.1 UniProtKB/TrEMBL
  ENSCAFT00000109535.1 UniProtKB/TrEMBL
  ENSCAFT00030001074.1 UniProtKB/TrEMBL
  ENSCAFT00030001134.1 UniProtKB/TrEMBL
  ENSCAFT00040030966.1 UniProtKB/TrEMBL
  ENSCAFT00040031097.1 UniProtKB/TrEMBL
  ENSCAFT00845040942.1 UniProtKB/TrEMBL
  ENSCAFT00845041000 ENTREZGENE
  ENSCAFT00845041000.1 UniProtKB/TrEMBL
  ENSCAFT00845041051.1 UniProtKB/TrEMBL
InterPro Bcl-2-like_sf UniProtKB/TrEMBL
NCBI Gene BCL2L12 ENTREZGENE
PANTHER BCL-2-LIKE PROTEIN 12 UniProtKB/TrEMBL
  SI:CH73-248E21.1 UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt A0A8C0M249_CANLF UniProtKB/TrEMBL
  A0A8C0SUP6_CANLF UniProtKB/TrEMBL
  A0A8I3PIK3_CANLF UniProtKB/TrEMBL
  A0A8I3PIV0_CANLF UniProtKB/TrEMBL
  A0A8I3PRV4_CANLF UniProtKB/TrEMBL
  A0A8P0S9A0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TUK5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53525 ENTREZGENE