NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6) - Rat Genome Database

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Gene: NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6) Canis lupus familiaris
Analyze
Symbol: NDUFA6
Name: NADH:ubiquinone oxidoreductase subunit A6
RGD ID: 12343260
Description: INVOLVED IN mitochondrial respiratory chain complex I assembly (inferred); response to oxidative stress (inferred); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Alzheimer's disease (ortholog); common variable immunodeficiency 4 (ortholog); FOUND IN mitochondrial respiratory chain complex I (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,283,951 - 23,292,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,283,933 - 23,292,638 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,218,678 - 23,226,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,028,457 - 24,036,987 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,028,436 - 24,037,168 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,746,101 - 23,754,602 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,066,922 - 24,075,444 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,240,891 - 24,249,421 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NDUFA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,283,951 - 23,292,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,283,933 - 23,292,638 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,218,678 - 23,226,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,028,457 - 24,036,987 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,028,436 - 24,037,168 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,746,101 - 23,754,602 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,066,922 - 24,075,444 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,240,891 - 24,249,421 (+)NCBIUU_Cfam_GSD_1.0
NDUFA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,085,526 - 42,090,772 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,085,526 - 42,090,884 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,481,530 - 42,486,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,811,476 - 40,816,834 (-)NCBINCBI36Build 36hg18NCBI36
Build 342240,806,030 - 40,811,388NCBI
Celera2226,287,732 - 26,293,090 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,447,717 - 25,453,074 (-)NCBIHuRef
CHM1_12242,441,649 - 42,447,020 (-)NCBICHM1_1
T2T-CHM13v2.02242,565,116 - 42,570,369 (-)NCBIT2T-CHM13v2.0
Ndufa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,234,342 - 82,238,438 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,234,341 - 82,238,523 (-)EnsemblGRCm39 Ensembl
GRCm381582,350,139 - 82,354,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,350,140 - 82,354,322 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,180,569 - 82,184,721 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,177,927 - 82,182,006 (-)NCBIMGSCv36mm8
Celera1584,474,298 - 84,478,444 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.56NCBI
Ndufa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,746,460 - 115,750,317 (-)NCBIGRCr8
mRatBN7.27113,866,382 - 113,870,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,866,382 - 113,870,239 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,622,145 - 115,626,002 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,845,664 - 117,849,521 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,815,112 - 117,818,969 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,583,062 - 123,586,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,583,062 - 123,586,919 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,567,781 - 123,571,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,726,071 - 120,729,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,760,305 - 120,764,140 (-)NCBI
Celera7110,181,220 - 110,185,077 (-)NCBICelera
Cytogenetic Map7q34NCBI
Ndufa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,485,678 - 27,491,757 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541327,485,678 - 27,491,757 (-)NCBIChiLan1.0ChiLan1.0
NDUFA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,916,789 - 51,925,113 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12254,615,956 - 54,624,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02222,978,954 - 22,987,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12241,066,111 - 41,074,852 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2241,066,111 - 41,074,852 (-)Ensemblpanpan1.1panPan2
Ndufa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,912,544 - 6,919,368 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493671860,231 - 67,654 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493671860,797 - 67,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,562,011 - 6,567,647 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,562,074 - 6,567,321 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,786,926 - 3,792,175 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,622,172 - 24,630,977 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045100,764,521 - 100,773,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247526,658,824 - 6,663,830 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247526,658,807 - 6,663,830 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NDUFA6
93 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001517   ⟹   ENSCAFP00000001394
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1023,283,933 - 23,292,638 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026894   ⟹   ENSCAFP00845021172
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1024,028,436 - 24,037,168 (+)Ensembl
RefSeq Acc Id: XM_005625799   ⟹   XP_005625856
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11023,283,951 - 23,292,457 (+)NCBI
Dog10K_Boxer_Tasha1023,218,678 - 23,226,545 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038488442   ⟹   XP_038344370
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11023,746,101 - 23,754,602 (+)NCBI
RefSeq Acc Id: XM_038550365   ⟹   XP_038406293
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01024,240,891 - 24,249,421 (+)NCBI
RefSeq Acc Id: XM_038614335   ⟹   XP_038470263
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01024,066,922 - 24,075,444 (+)NCBI
RefSeq Acc Id: XM_038679681   ⟹   XP_038535609
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01024,028,457 - 24,036,987 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005625856   ⟸   XM_005625799
- UniProtKB: A0A8C0SQ57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001394   ⟸   ENSCAFT00000001517
RefSeq Acc Id: XP_038344370   ⟸   XM_038488442
RefSeq Acc Id: XP_038470263   ⟸   XM_038614335
RefSeq Acc Id: XP_038535609   ⟸   XM_038679681
- UniProtKB: A0A8C0SQ57 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406293   ⟸   XM_038550365
- UniProtKB: A0A8C0SQ57 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845021172   ⟸   ENSCAFT00845026894
Protein Domains
Complex 1 LYR protein

Promoters
RGD ID:13684943
Promoter ID:EPDNEW_C3010
Type:multiple initiation site
Name:NDUFA6_1
Description:NADH:ubiquinone oxidoreductase subunit A6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11023,283,984 - 23,284,044EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000982 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040015166 UniProtKB/TrEMBL
  ENSCAFG00845015040 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001517.5 UniProtKB/TrEMBL
  ENSCAFT00040028040.1 UniProtKB/TrEMBL
  ENSCAFT00845026894 ENTREZGENE
  ENSCAFT00845026894.1 UniProtKB/TrEMBL
InterPro Complex1_LYR_dom UniProtKB/TrEMBL
  Complex1_LYR_NDUFA6_LYRM6 UniProtKB/TrEMBL
  NADH_Ub_cplx-1_asu_su-6 UniProtKB/TrEMBL
NCBI Gene NDUFA6 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6 UniProtKB/TrEMBL
  PTHR12964 UniProtKB/TrEMBL
Pfam Complex1_LYR UniProtKB/TrEMBL
PIRSF NDUA6 UniProtKB/TrEMBL
UniProt A0A8C0SQ57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NQX4_CANLF UniProtKB/TrEMBL
  A0A8P0N461_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43689 ENTREZGENE