ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2) - Rat Genome Database

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Gene: ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2) Canis lupus familiaris
Analyze
Symbol: ADAMTS2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
RGD ID: 12342790
Description: ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); metallopeptidase activity (inferred); INVOLVED IN collagen fibril organization (ortholog); lung development (ortholog); protein processing (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Ehlers-Danlos syndrome (ortholog); Ehlers-Danlos syndrome dermatosparaxis type (ortholog); FOUND IN collagen-containing extracellular matrix (inferred); extracellular matrix (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,279,983 - 2,504,630 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,280,108 - 2,502,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,405,139 - 2,628,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,257,166 - 2,480,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,256,096 - 2,478,201 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,228,645 - 2,452,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,306,958 - 2,530,502 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,547,778 - 2,771,332 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:31294848  


Genomics

Comparative Map Data
ADAMTS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,279,983 - 2,504,630 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,280,108 - 2,502,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,405,139 - 2,628,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,257,166 - 2,480,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,256,096 - 2,478,201 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,228,645 - 2,452,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,306,958 - 2,530,502 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,547,778 - 2,771,332 (+)NCBIUU_Cfam_GSD_1.0
ADAMTS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,110,853 - 179,345,461 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,110,853 - 179,345,461 (-)EnsemblGRCh38hg38GRCh38
GRCh375178,537,854 - 178,772,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,473,456 - 178,704,935 (-)NCBINCBI36Build 36hg18NCBI36
Build 345178,510,735 - 178,704,935NCBI
Celera5174,165,082 - 174,399,060 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,265,383 - 173,499,085 (-)NCBIHuRef
CHM1_15177,971,059 - 178,205,092 (-)NCBICHM1_1
T2T-CHM13v2.05179,664,045 - 179,898,855 (-)NCBIT2T-CHM13v2.0
Adamts2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,492,912 - 50,698,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,492,911 - 50,698,400 (+)EnsemblGRCm39 Ensembl
GRCm381150,602,085 - 50,807,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,602,084 - 50,807,573 (+)EnsemblGRCm38mm10GRCm38
MGSCv371150,415,587 - 50,617,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,445,508 - 50,647,472 (+)NCBIMGSCv36mm8
Celera1155,162,823 - 55,366,156 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.78NCBI
Adamts2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,422,030 - 35,627,483 (+)NCBIGRCr8
mRatBN7.21034,920,992 - 35,126,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,921,049 - 35,123,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,593,339 - 39,808,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,132,574 - 8,348,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,587,008 - 34,802,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,098,051 - 36,304,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,098,051 - 36,304,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,868,666 - 36,075,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,168,655 - 36,377,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1034,268,635 - 34,483,095 (+)NCBICelera
Cytogenetic Map10q22NCBI
Adamts2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554081,157,740 - 1,367,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554081,157,826 - 1,367,146 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,047,680 - 174,289,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,182,352 - 172,428,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,264,811 - 174,502,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,554,934 - 181,785,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,557,928 - 181,786,175 (-)Ensemblpanpan1.1panPan2
Adamts2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213120,182,091 - 120,431,360 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,394,119 - 1,641,130 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,394,119 - 1,643,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl279,182,943 - 79,406,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1279,182,901 - 79,406,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,866,167 - 81,010,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,852,588 - 81,081,593 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,852,331 - 81,080,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,207,935 - 12,439,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,070,087 - 42,264,849 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,070,069 - 42,264,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAMTS2
1657 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 6
Low 5 5 21 5 3 5 1 2 12 8 10
Below cutoff 1 1 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000511   ⟹   ENSCAFP00000000462
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl112,280,108 - 2,502,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000070562   ⟹   ENSCAFP00000051835
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl112,281,175 - 2,502,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000073279   ⟹   ENSCAFP00000060484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl112,281,175 - 2,502,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090500   ⟹   ENSCAFP00000064700
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl112,281,175 - 2,502,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015551   ⟹   ENSCAFP00845012082
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl112,256,096 - 2,478,201 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015595   ⟹   ENSCAFP00845012120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl112,256,096 - 2,436,187 (+)Ensembl
RefSeq Acc Id: XM_038491142   ⟹   XP_038347070
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1112,228,645 - 2,452,092 (+)NCBI
RefSeq Acc Id: XM_038551648   ⟹   XP_038407576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0112,547,778 - 2,771,332 (+)NCBI
RefSeq Acc Id: XM_038615542   ⟹   XP_038471470
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0112,306,958 - 2,530,502 (+)NCBI
RefSeq Acc Id: XM_038660406   ⟹   XP_038516334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha112,405,139 - 2,628,591 (+)NCBI
RefSeq Acc Id: XM_038681038   ⟹   XP_038536966
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0112,257,166 - 2,480,747 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000051835   ⟸   ENSCAFT00000070562
RefSeq Acc Id: ENSCAFP00000060484   ⟸   ENSCAFT00000073279
RefSeq Acc Id: ENSCAFP00000000462   ⟸   ENSCAFT00000000511
RefSeq Acc Id: ENSCAFP00000064700   ⟸   ENSCAFT00000090500
RefSeq Acc Id: XP_038347070   ⟸   XM_038491142
RefSeq Acc Id: XP_038471470   ⟸   XM_038615542
RefSeq Acc Id: XP_038536966   ⟸   XM_038681038
- UniProtKB: A0A8C0MFB3 (UniProtKB/TrEMBL),   A0A8C0RDN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516334   ⟸   XM_038660406
- UniProtKB: A0A8C0MFB3 (UniProtKB/TrEMBL),   A0A8C0RDN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407576   ⟸   XM_038551648
- UniProtKB: A0A8C0MFB3 (UniProtKB/TrEMBL),   A0A8C0RDN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012120   ⟸   ENSCAFT00845015595
RefSeq Acc Id: ENSCAFP00845012082   ⟸   ENSCAFT00845015551
Protein Domains
Peptidase M12B   PLAC

Promoters
RGD ID:13685129
Promoter ID:EPDNEW_C3197
Type:initiation region
Name:ADAMTS2_1
Description:ADAM metallopeptidase with thrombospondin type 1 motif 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1112,279,974 - 2,280,034EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000334 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005692 UniProtKB/TrEMBL
  ENSCAFG00040009286 UniProtKB/TrEMBL
  ENSCAFG00845008674 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000511.5 UniProtKB/TrEMBL
  ENSCAFT00000090500.2 UniProtKB/TrEMBL
  ENSCAFT00030010701.1 UniProtKB/TrEMBL
  ENSCAFT00030010819.1 UniProtKB/TrEMBL
  ENSCAFT00030010904.1 UniProtKB/TrEMBL
  ENSCAFT00030011078.1 UniProtKB/TrEMBL
  ENSCAFT00030011119.1 UniProtKB/TrEMBL
  ENSCAFT00040017342.1 UniProtKB/TrEMBL
  ENSCAFT00040017546.1 UniProtKB/TrEMBL
  ENSCAFT00845015551 ENTREZGENE
  ENSCAFT00845015551.1 UniProtKB/TrEMBL
  ENSCAFT00845015595.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_2 UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  ADAMTS_spacer1 UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS2 UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene ADAMTS2 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  Reprolysin_5 UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS ADAMTS2 UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A8C0MCM7_CANLF UniProtKB/TrEMBL
  A0A8C0MCQ2_CANLF UniProtKB/TrEMBL
  A0A8C0MFB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MH25_CANLF UniProtKB/TrEMBL
  A0A8C0RDN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S2R1_CANLF UniProtKB/TrEMBL
  A0A8I3MZD5_CANLF UniProtKB/TrEMBL
  A0A8I3N503_CANLF UniProtKB/TrEMBL
  A0A8P0N3L5_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0TG61 UniProtKB/TrEMBL
VGNC ID VGNC:37598 ENTREZGENE