KDF1 (keratinocyte differentiation factor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: KDF1 (keratinocyte differentiation factor 1) Canis lupus familiaris
Analyze
Symbol: KDF1
Name: keratinocyte differentiation factor 1
RGD ID: 12316323
Description: INVOLVED IN keratinocyte development (ortholog); keratinocyte proliferation (ortholog); negative regulation of keratinocyte proliferation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 12 (ortholog); genetic disease (ortholog); FOUND IN cell cortex (inferred); cell junction (inferred); cell leading edge (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C2H1orf172
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,198,278 - 73,206,691 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,197,580 - 73,207,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,776,306 - 69,784,741 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,761,802 - 73,770,459 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,767,812 - 73,769,916 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,587,054 - 70,595,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,592,397 - 71,600,846 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,595,415 - 72,603,855 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KDF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,198,278 - 73,206,691 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,197,580 - 73,207,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,776,306 - 69,784,741 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,761,802 - 73,770,459 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,767,812 - 73,769,916 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,587,054 - 70,595,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,592,397 - 71,600,846 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,595,415 - 72,603,855 (+)NCBIUU_Cfam_GSD_1.0
KDF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,949,562 - 26,960,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,949,562 - 26,960,468 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,276,053 - 27,286,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,148,648 - 27,159,484 (-)NCBINCBI36Build 36hg18NCBI36
Celera125,673,140 - 25,683,994 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,529,626 - 25,540,470 (-)NCBIHuRef
CHM1_1127,389,393 - 27,400,245 (-)NCBICHM1_1
T2T-CHM13v2.0126,787,618 - 26,798,705 (-)NCBIT2T-CHM13v2.0
Kdf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,246,274 - 133,258,101 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,246,274 - 133,258,101 (+)EnsemblGRCm39 Ensembl
GRCm384133,518,733 - 133,530,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,518,963 - 133,530,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv374133,074,878 - 133,086,705 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,791,111 - 132,802,866 (+)NCBIMGSCv36mm8
Celera4131,688,107 - 131,699,976 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Kdf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,028,152 - 151,039,753 (+)NCBIGRCr8
mRatBN7.25145,744,753 - 145,758,150 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,745,099 - 145,755,878 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,447,139 - 148,457,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,216,744 - 150,227,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,203,304 - 150,214,086 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,740,902 - 151,752,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,741,817 - 151,752,597 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,430,208 - 155,442,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5144,165,183 - 144,176,199 (+)NCBICelera
Cytogenetic Map5q36NCBI
Kdf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,280,391 - 6,289,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,280,391 - 6,288,985 (-)NCBIChiLan1.0ChiLan1.0
KDF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,910,727 - 199,921,937 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,014,873 - 199,029,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,210,572 - 26,221,991 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,267,106 - 27,277,713 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,267,106 - 27,277,684 (-)Ensemblpanpan1.1panPan2
Kdf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,517,294 - 45,526,324 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,343,539 - 11,351,168 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,341,415 - 11,351,066 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,254,499 - 84,265,041 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,254,493 - 84,265,112 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,824,691 - 77,835,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,803,540 - 105,814,461 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,811,182 - 105,816,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603310,618,673 - 10,630,514 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476410,927,931 - 10,936,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476410,927,426 - 10,936,771 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KDF1
70 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 3
Low 5 19 6 6 6 12 8 7 6
Below cutoff 5 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019397   ⟹   ENSCAFP00000017994
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl273,197,580 - 73,207,153 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019717   ⟹   ENSCAFP00845015430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl273,767,812 - 73,769,916 (+)Ensembl
RefSeq Acc Id: XM_005617723   ⟹   XP_005617780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1273,198,278 - 73,206,691 (+)NCBI
Dog10K_Boxer_Tasha269,776,306 - 69,784,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038470582   ⟹   XP_038326510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1270,587,132 - 70,595,485 (+)NCBI
RefSeq Acc Id: XM_038470583   ⟹   XP_038326511
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1270,587,054 - 70,595,485 (+)NCBI
RefSeq Acc Id: XM_038531425   ⟹   XP_038387353
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0272,595,493 - 72,603,855 (+)NCBI
RefSeq Acc Id: XM_038531426   ⟹   XP_038387354
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0272,595,415 - 72,603,855 (+)NCBI
RefSeq Acc Id: XM_038595647   ⟹   XP_038451575
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0271,592,475 - 71,600,846 (+)NCBI
RefSeq Acc Id: XM_038595648   ⟹   XP_038451576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0271,592,397 - 71,600,846 (+)NCBI
RefSeq Acc Id: XM_038659728   ⟹   XP_038515656
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0273,761,802 - 73,770,459 (+)NCBI
RefSeq Acc Id: XM_849847   ⟹   XP_854940
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1273,198,362 - 73,206,691 (+)NCBI
Dog10K_Boxer_Tasha269,776,384 - 69,784,741 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005617780   ⟸   XM_005617723
- UniProtKB: A0A8C0N8E5 (UniProtKB/TrEMBL),   A0A8C0LB72 (UniProtKB/TrEMBL),   A0A8I3NID7 (UniProtKB/TrEMBL),   A0A8C0Q6E3 (UniProtKB/TrEMBL),   A0A8P0PMX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_854940   ⟸   XM_849847
- UniProtKB: A0A8C0N8E5 (UniProtKB/TrEMBL),   A0A8C0LB72 (UniProtKB/TrEMBL),   A0A8I3NID7 (UniProtKB/TrEMBL),   A0A8C0Q6E3 (UniProtKB/TrEMBL),   A0A8P0PMX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017994   ⟸   ENSCAFT00000019397
RefSeq Acc Id: XP_038326511   ⟸   XM_038470583
RefSeq Acc Id: XP_038326510   ⟸   XM_038470582
RefSeq Acc Id: XP_038451576   ⟸   XM_038595648
RefSeq Acc Id: XP_038451575   ⟸   XM_038595647
RefSeq Acc Id: XP_038515656   ⟸   XM_038659728
- UniProtKB: A0A8C0N8E5 (UniProtKB/TrEMBL),   A0A8C0LB72 (UniProtKB/TrEMBL),   A0A8I3NID7 (UniProtKB/TrEMBL),   A0A8C0Q6E3 (UniProtKB/TrEMBL),   A0A8P0PMX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387354   ⟸   XM_038531426
- UniProtKB: A0A8C0LB72 (UniProtKB/TrEMBL),   A0A8C0N8E5 (UniProtKB/TrEMBL),   A0A8C0Q6E3 (UniProtKB/TrEMBL),   A0A8I3NID7 (UniProtKB/TrEMBL),   A0A8P0PMX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387353   ⟸   XM_038531425
- UniProtKB: A0A8C0LB72 (UniProtKB/TrEMBL),   A0A8C0N8E5 (UniProtKB/TrEMBL),   A0A8C0Q6E3 (UniProtKB/TrEMBL),   A0A8I3NID7 (UniProtKB/TrEMBL),   A0A8P0PMX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845015430   ⟸   ENSCAFT00845019717


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012214 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012843 UniProtKB/TrEMBL
  ENSCAFG00040003515 UniProtKB/TrEMBL
  ENSCAFG00845011124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019397.5 UniProtKB/TrEMBL
  ENSCAFT00000109878.1 UniProtKB/TrEMBL
  ENSCAFT00030023747.1 UniProtKB/TrEMBL
  ENSCAFT00040006682.1 UniProtKB/TrEMBL
  ENSCAFT00040006685.1 UniProtKB/TrEMBL
  ENSCAFT00845019717 ENTREZGENE
  ENSCAFT00845019717.1 UniProtKB/TrEMBL
InterPro KDF1 UniProtKB/TrEMBL
KEGG Report cfa:612121 UniProtKB/TrEMBL
NCBI Gene KDF1 ENTREZGENE
PANTHER KERATINOCYTE DIFFERENTIATION FACTOR 1 UniProtKB/TrEMBL
  PTHR35085 UniProtKB/TrEMBL
Pfam DUF4656 UniProtKB/TrEMBL
UniProt A0A8C0LB72 ENTREZGENE
  A0A8C0N8E5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q6E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NID7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PMX8 ENTREZGENE
UniProt Secondary A0A8P0PMX8 UniProtKB/TrEMBL
VGNC ID VGNC:42317 ENTREZGENE