KLHL10 (kelch like family member 10) - Rat Genome Database

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Gene: KLHL10 (kelch like family member 10) Canis lupus familiaris
Analyze
Symbol: KLHL10
Name: kelch like family member 10
RGD ID: 12296765
Description: INVOLVED IN cell morphogenesis (ortholog); fertilization (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH spermatogenic failure 11 (ortholog); spermatogenic failure 3 (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 10; kelch-like protein 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,983,869 - 20,989,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,983,833 - 20,989,140 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,446,642 - 20,451,929 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,705,156 - 21,710,445 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,705,120 - 21,710,429 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,490,992 - 20,496,278 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,757,114 - 20,762,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,861,007 - 20,866,295 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,983,869 - 20,989,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,983,833 - 20,989,140 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,446,642 - 20,451,929 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,705,156 - 21,710,445 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,705,120 - 21,710,429 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,490,992 - 20,496,278 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,757,114 - 20,762,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,861,007 - 20,866,295 (-)NCBIUU_Cfam_GSD_1.0
KLHL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,835,685 - 41,848,384 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,835,685 - 41,848,384 (+)EnsemblGRCh38hg38GRCh38
GRCh371739,991,937 - 40,004,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,247,569 - 37,258,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,247,606 - 37,258,123NCBI
Celera1736,645,384 - 36,655,940 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,755,927 - 35,766,567 (+)NCBIHuRef
CHM1_11740,229,657 - 40,240,209 (+)NCBICHM1_1
T2T-CHM13v2.01742,692,241 - 42,704,935 (+)NCBIT2T-CHM13v2.0
Klhl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,331,954 - 100,347,853 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,332,743 - 100,347,848 (+)EnsemblGRCm39 Ensembl
GRCm3811100,441,128 - 100,457,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,441,917 - 100,457,022 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,303,238 - 100,318,338 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,258,014 - 100,273,114 (+)NCBIMGSCv36mm8
Celera11111,060,316 - 111,075,414 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Klhl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,876,804 - 85,893,081 (+)NCBIGRCr8
mRatBN7.21085,376,442 - 85,392,720 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,376,442 - 85,392,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,412,747 - 90,428,874 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,891,874 - 89,908,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,284,717 - 85,300,994 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,356,652 - 88,372,929 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,356,615 - 88,372,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,149,899 - 88,166,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,385,247 - 89,401,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,399,616 - 89,415,984 (+)NCBI
Celera1084,093,937 - 84,110,077 (+)NCBICelera
Cytogenetic Map10q31NCBI
Klhl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,042,128 - 16,047,718 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,042,128 - 16,047,718 (+)NCBIChiLan1.0ChiLan1.0
KLHL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,133,592 - 23,146,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,023,718 - 25,036,397 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,465,507 - 15,478,190 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,684,157 - 15,696,563 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,684,157 - 15,696,563 (-)Ensemblpanpan1.1panPan2
Klhl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,329,509 - 20,337,909 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,737,252 - 16,745,586 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,737,241 - 16,747,801 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,854,407 - 20,861,662 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,851,168 - 20,862,183 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLHL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,412,428 - 64,423,166 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,412,516 - 64,422,674 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,240,599 - 35,251,585 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,921,414 - 1,928,161 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,922,605 - 1,928,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHL10
35 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 1 1
Below cutoff 4 5 17 3 5 3 3 6 12 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025122   ⟹   ENSCAFP00000023319
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl920,983,833 - 20,989,140 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020218   ⟹   ENSCAFP00845015848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl921,705,120 - 21,710,429 (-)Ensembl
RefSeq Acc Id: XM_022422993   ⟹   XP_022278701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1920,983,869 - 20,988,774 (-)NCBI
Dog10K_Boxer_Tasha920,446,642 - 20,451,543 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038485565   ⟹   XP_038341493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1920,490,992 - 20,496,278 (-)NCBI
RefSeq Acc Id: XM_038485566   ⟹   XP_038341494
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1920,490,992 - 20,495,892 (-)NCBI
RefSeq Acc Id: XM_038547344   ⟹   XP_038403272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0920,861,007 - 20,866,295 (-)NCBI
RefSeq Acc Id: XM_038547345   ⟹   XP_038403273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0920,861,007 - 20,865,909 (-)NCBI
RefSeq Acc Id: XM_038611312   ⟹   XP_038467240
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0920,757,114 - 20,762,401 (-)NCBI
RefSeq Acc Id: XM_038611314   ⟹   XP_038467242
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0920,757,114 - 20,762,015 (-)NCBI
RefSeq Acc Id: XM_038676503   ⟹   XP_038532431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0921,705,156 - 21,710,445 (-)NCBI
RefSeq Acc Id: XM_038676504   ⟹   XP_038532432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0921,705,156 - 21,710,059 (-)NCBI
RefSeq Acc Id: XM_537641   ⟹   XP_537641
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1920,983,869 - 20,989,159 (-)NCBI
Dog10K_Boxer_Tasha920,446,642 - 20,451,929 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_537641   ⟸   XM_537641
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RPB1 (UniProtKB/TrEMBL),   A0A8C0L1P4 (UniProtKB/TrEMBL),   A0A8I3N945 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278701   ⟸   XM_022422993
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000023319   ⟸   ENSCAFT00000025122
RefSeq Acc Id: XP_038341493   ⟸   XM_038485565
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038341494   ⟸   XM_038485566
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038467240   ⟸   XM_038611312
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038467242   ⟸   XM_038611314
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038532431   ⟸   XM_038676503
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RPB1 (UniProtKB/TrEMBL),   A0A8C0L1P4 (UniProtKB/TrEMBL),   A0A8I3N945 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532432   ⟸   XM_038676504
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038403272   ⟸   XM_038547344
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L1P4 (UniProtKB/TrEMBL),   A0A8C0RPB1 (UniProtKB/TrEMBL),   A0A8I3N945 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403273   ⟸   XM_038547345
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845015848   ⟸   ENSCAFT00845020218
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015849 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019916 UniProtKB/TrEMBL
  ENSCAFG00040009878 UniProtKB/TrEMBL
  ENSCAFG00845011409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025122.5 UniProtKB/TrEMBL
  ENSCAFT00030036652.1 UniProtKB/TrEMBL
  ENSCAFT00040018298.1 UniProtKB/TrEMBL
  ENSCAFT00845020218 ENTREZGENE
  ENSCAFT00845020218.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL10_BTB/POZ UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL10 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  RING CANAL KELCH PROTEIN UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A8C0L1P4 ENTREZGENE
  A0A8C0RPB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N945 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42446 ENTREZGENE