P3H1 (prolyl 3-hydroxylase 1) - Rat Genome Database

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Gene: P3H1 (prolyl 3-hydroxylase 1) Canis lupus familiaris
Analyze
Symbol: P3H1
Name: prolyl 3-hydroxylase 1
RGD ID: 12281569
Description: ENCODES a protein that exhibits dioxygenase activity (inferred); iron ion binding (inferred); L-ascorbic acid binding (inferred); INVOLVED IN collagen fibril organization (ortholog); negative regulation of cell growth (ortholog); positive regulation of neuron projection development (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); osteogenesis imperfecta (ortholog); FOUND IN basement membrane (ortholog); cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LEPRE1; leucine proline-enriched proteoglycan (leprecan) 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115603,436 - 621,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15603,329 - 621,568 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15859,084 - 876,791 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015685,742 - 703,402 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15685,532 - 703,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115595,219 - 612,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015656,713 - 674,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015671,787 - 689,446 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
P3H1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115603,436 - 621,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15603,329 - 621,568 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15859,084 - 876,791 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015685,742 - 703,402 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15685,532 - 703,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115595,219 - 612,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015656,713 - 674,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015671,787 - 689,446 (+)NCBIUU_Cfam_GSD_1.0
P3H1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,746,374 - 42,767,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,746,335 - 42,767,084 (-)EnsemblGRCh38hg38GRCh38
GRCh37143,212,045 - 43,232,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,984,633 - 43,005,270 (-)NCBINCBI36Build 36hg18NCBI36
Celera141,493,937 - 41,514,687 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,331,989 - 41,352,738 (-)NCBIHuRef
CHM1_1143,328,805 - 43,349,560 (-)NCBICHM1_1
T2T-CHM13v2.0142,616,864 - 42,637,518 (-)NCBIT2T-CHM13v2.0
P3h1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,090,112 - 119,106,174 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,090,112 - 119,106,172 (+)EnsemblGRCm39 Ensembl
GRCm384119,232,915 - 119,248,977 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,232,915 - 119,248,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv374118,905,520 - 118,921,582 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,730,878 - 118,746,299 (+)NCBIMGSCv36mm8
Celera4117,960,655 - 117,976,715 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
P3h1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,127,240 - 138,141,974 (+)NCBIGRCr8
mRatBN7.25132,841,868 - 132,856,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,841,928 - 132,856,659 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,569,568 - 135,584,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,326,032 - 137,340,722 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,346,618 - 137,361,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,279,597 - 138,294,280 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,279,506 - 138,294,262 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,091,640 - 142,106,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,816,323 - 139,831,409 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15139,821,548 - 139,836,635 (+)NCBI
Celera5131,367,576 - 131,382,262 (+)NCBICelera
Cytogenetic Map5q36NCBI
P3h1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,275,599 - 2,292,303 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,276,080 - 2,292,303 (-)NCBIChiLan1.0ChiLan1.0
P3H1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,045,565 - 184,065,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,187,228 - 183,206,973 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,046,128 - 42,065,718 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,423,579 - 43,443,443 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,423,900 - 43,443,336 (-)Ensemblpanpan1.1panPan2
P3h1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,252,481 - 58,268,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,075,312 - 24,093,399 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,077,270 - 24,093,399 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P3H1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6168,668,311 - 168,687,829 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16168,668,275 - 168,687,832 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,143,283 - 156,159,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P3H1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12090,166,622 - 90,185,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2090,166,700 - 90,186,115 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603326,724,625 - 26,743,984 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P3h1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,988,096 - 2,003,319 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248921,988,309 - 2,003,285 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P3H1
163 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 22 6 6 6 6 12 10 6
Low 1 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003998   ⟹   ENSCAFP00000003692
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl15603,329 - 621,568 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028409   ⟹   ENSCAFP00845022348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl15685,532 - 703,398 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028472   ⟹   ENSCAFP00845022397
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl15685,532 - 703,398 (+)Ensembl
RefSeq Acc Id: XM_038451776   ⟹   XP_038307704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha15859,084 - 876,791 (+)NCBI
RefSeq Acc Id: XM_038451777   ⟹   XP_038307705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha15859,784 - 876,791 (+)NCBI
RefSeq Acc Id: XM_038496770   ⟹   XP_038352698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.115595,219 - 612,872 (+)NCBI
RefSeq Acc Id: XM_038557622   ⟹   XP_038413550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.015671,787 - 689,446 (+)NCBI
RefSeq Acc Id: XM_038621521   ⟹   XP_038477449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.015656,713 - 674,330 (+)NCBI
RefSeq Acc Id: XM_038687288   ⟹   XP_038543216
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.015685,742 - 703,402 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000003692   ⟸   ENSCAFT00000003998
RefSeq Acc Id: XP_038352698   ⟸   XM_038496770
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038477449   ⟸   XM_038621521
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038543216   ⟸   XM_038687288
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JQP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307704   ⟸   XM_038451776
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JQP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307705   ⟸   XM_038451777
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038413550   ⟸   XM_038557622
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JQP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022348   ⟸   ENSCAFT00845028409
RefSeq Acc Id: ENSCAFP00845022397   ⟸   ENSCAFT00845028472
Protein Domains
Fe2OG dioxygenase

Promoters
RGD ID:13685834
Promoter ID:EPDNEW_C3903
Type:initiation region
Name:P3H1_1
Description:prolyl 3-hydroxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.115603,436 - 603,496EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002526 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023769 UniProtKB/TrEMBL
  ENSCAFG00845015744 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003998.6 UniProtKB/TrEMBL
  ENSCAFT00000105292.1 UniProtKB/TrEMBL
  ENSCAFT00030043719.1 UniProtKB/TrEMBL
  ENSCAFT00030043772.1 UniProtKB/TrEMBL
  ENSCAFT00845028409 ENTREZGENE
  ENSCAFT00845028409.1 UniProtKB/TrEMBL
  ENSCAFT00845028472.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  q2cbj1_9rhob like domain UniProtKB/TrEMBL
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/TrEMBL
  P3H UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
NCBI Gene P3H1 ENTREZGENE
PANTHER PTHR14049 UniProtKB/TrEMBL
  PTHR14049:SF5 UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/TrEMBL
PROSITE FE2OG_OXY UniProtKB/TrEMBL
SMART P4Hc UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C0JQP8 ENTREZGENE
  A0A8C0P9I7_CANLF UniProtKB/TrEMBL
  A0A8C0PAI8_CANLF UniProtKB/TrEMBL
  A0A8I3NPB3_CANLF UniProtKB/TrEMBL
  A0A8I3NYQ2_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0N5K1 UniProtKB/TrEMBL
  A0A8P0TRT4 UniProtKB/TrEMBL
VGNC ID VGNC:44219 ENTREZGENE