KLHL2 (kelch like family member 2) - Rat Genome Database

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Gene: KLHL2 (kelch like family member 2) Canis lupus familiaris
Analyze
Symbol: KLHL2
Name: kelch like family member 2
RGD ID: 12276043
Description: ENCODES a protein that exhibits actin binding (inferred); identical protein binding (inferred); ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN protein ubiquitination (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 2, Mayven; kelch-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,204,371 - 61,289,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,204,363 - 61,298,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,204,371 - 61,289,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,204,363 - 61,298,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBIUU_Cfam_GSD_1.0
KLHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384165,207,561 - 165,323,156 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4165,207,561 - 165,323,156 (+)EnsemblGRCh38hg38GRCh38
GRCh374166,128,713 - 166,244,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,348,238 - 166,463,749 (+)NCBINCBI36Build 36hg18NCBI36
Build 344166,486,395 - 166,601,903NCBI
Celera4163,459,950 - 163,579,735 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,880,568 - 161,996,120 (+)NCBIHuRef
CHM1_14166,105,246 - 166,220,767 (+)NCBICHM1_1
T2T-CHM13v2.04168,553,548 - 168,669,151 (+)NCBIT2T-CHM13v2.0
Klhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,192,707 - 65,302,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,192,709 - 65,302,669 (-)EnsemblGRCm39 Ensembl
GRCm38864,739,673 - 64,850,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,739,675 - 64,850,017 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,335,578 - 67,373,716 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36867,631,868 - 67,672,057 (-)NCBIMGSCv36mm8
Celera867,303,934 - 67,417,078 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.3NCBI
Klhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,627,171 - 29,739,782 (+)NCBIGRCr8
mRatBN7.21624,860,744 - 24,973,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,860,667 - 24,973,341 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01626,755,246 - 26,852,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,739,389 - 26,852,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,622,472 - 26,731,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,634,400 - 26,690,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11626,648,722 - 26,691,115 (+)NCBI
Celera1624,962,535 - 25,057,740 (+)NCBICelera
Cytogenetic Map16p13NCBI
Klhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540340,012,453 - 40,094,853 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540340,013,840 - 40,094,853 (-)NCBIChiLan1.0ChiLan1.0
KLHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,956,665 - 163,072,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,314,357 - 163,430,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,402,905 - 157,518,639 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,572,832 - 169,602,304 (+)NCBIpanpan1.1PanPan1.1panPan2
Klhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494317,804,579 - 17,886,216 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555684,093 - 766,006 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936555684,300 - 765,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl843,749,423 - 43,870,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1843,749,423 - 43,871,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2845,677,143 - 45,798,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,569,027 - 111,684,065 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7111,569,125 - 111,684,879 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603791,412,273 - 91,534,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475811,649,396 - 11,765,961 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475811,649,603 - 11,765,636 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHL2
1344 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 15 3 6 3 6 12 7 10 6
Low 5 7 3 3 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014062   ⟹   ENSCAFP00000013009
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,204,363 - 61,288,207 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000068729   ⟹   ENSCAFP00000059187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,204,371 - 61,298,581 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069639   ⟹   ENSCAFP00000046681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,204,363 - 61,284,221 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080069   ⟹   ENSCAFP00000045789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,216,676 - 61,288,207 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012505   ⟹   ENSCAFP00845009771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012541   ⟹   ENSCAFP00845009797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1562,079,193 - 62,151,392 (+)Ensembl
RefSeq Acc Id: XM_038447749   ⟹   XP_038303677
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBI
RefSeq Acc Id: XM_038496754   ⟹   XP_038352682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBI
RefSeq Acc Id: XM_038559150   ⟹   XP_038415078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBI
RefSeq Acc Id: XM_038559151   ⟹   XP_038415079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01561,697,761 - 61,770,206 (+)NCBI
RefSeq Acc Id: XM_038623099   ⟹   XP_038479027
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBI
RefSeq Acc Id: XM_038688771   ⟹   XP_038544699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000045789   ⟸   ENSCAFT00000080069
RefSeq Acc Id: ENSCAFP00000046681   ⟸   ENSCAFT00000069639
RefSeq Acc Id: ENSCAFP00000013009   ⟸   ENSCAFT00000014062
RefSeq Acc Id: ENSCAFP00000059187   ⟸   ENSCAFT00000068729
RefSeq Acc Id: XP_038352682   ⟸   XM_038496754
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479027   ⟸   XM_038623099
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038544699   ⟸   XM_038688771
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NR27 (UniProtKB/TrEMBL),   A0A8I3N4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038303677   ⟸   XM_038447749
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NR27 (UniProtKB/TrEMBL),   A0A8I3N4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415078   ⟸   XM_038559150
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NR27 (UniProtKB/TrEMBL),   A0A8I3N4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415079   ⟸   XM_038559151
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845009771   ⟸   ENSCAFT00845012505
RefSeq Acc Id: ENSCAFP00845009797   ⟸   ENSCAFT00845012541
Protein Domains
BACK   BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008844 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017999 UniProtKB/TrEMBL
  ENSCAFG00040005869 UniProtKB/TrEMBL
  ENSCAFG00845006973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000068729.2 UniProtKB/TrEMBL
  ENSCAFT00000080069.2 UniProtKB/TrEMBL
  ENSCAFT00030033615.1 UniProtKB/TrEMBL
  ENSCAFT00030033745.1 UniProtKB/TrEMBL
  ENSCAFT00030033896.1 UniProtKB/TrEMBL
  ENSCAFT00030034027.1 UniProtKB/TrEMBL
  ENSCAFT00030034158.1 UniProtKB/TrEMBL
  ENSCAFT00040010987.1 UniProtKB/TrEMBL
  ENSCAFT00040011042.1 UniProtKB/TrEMBL
  ENSCAFT00040011097.1 UniProtKB/TrEMBL
  ENSCAFT00845012505 ENTREZGENE
  ENSCAFT00845012505.1 UniProtKB/TrEMBL
  ENSCAFT00845012541.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL2_BTB/POZ UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL2 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP Galactose oxidase, central domain UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A8C0NMH6_CANLF UniProtKB/TrEMBL
  A0A8C0NR27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NU72_CANLF UniProtKB/TrEMBL
  A0A8C0NZQ0_CANLF UniProtKB/TrEMBL
  A0A8C0Q859_CANLF UniProtKB/TrEMBL
  A0A8C0RN25_CANLF UniProtKB/TrEMBL
  A0A8C0RYN9_CANLF UniProtKB/TrEMBL
  A0A8I3N4S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTQ2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42454 ENTREZGENE