HYPK (huntingtin interacting protein K) - Rat Genome Database

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Gene: HYPK (huntingtin interacting protein K) Canis lupus familiaris
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Symbol: HYPK
Name: huntingtin interacting protein K
RGD ID: 12262470
Description: ENCODES a protein that exhibits protein folding chaperone (inferred); INVOLVED IN negative regulation of apoptotic process (inferred); protein folding (inferred); protein stabilization (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cytoplasm (inferred); microtubule cytoskeleton (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C30H15orf63; huntingtin-interacting protein K
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,541,713 - 10,544,572 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,543,289 - 10,544,569 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,599,664 - 10,602,970 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03010,677,815 - 10,681,121 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,677,228 - 10,681,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,586,937 - 10,590,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,708,866 - 10,712,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,828,600 - 10,831,906 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HYPK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,541,713 - 10,544,572 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,543,289 - 10,544,569 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,599,664 - 10,602,970 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03010,677,815 - 10,681,121 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,677,228 - 10,681,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,586,937 - 10,590,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,708,866 - 10,712,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,828,600 - 10,831,906 (+)NCBIUU_Cfam_GSD_1.0
HYPK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381543,800,421 - 43,804,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1543,796,142 - 43,804,427 (+)EnsemblGRCh38hg38GRCh38
GRCh371544,092,619 - 44,096,625 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,879,913 - 41,882,079 (+)NCBINCBI36Build 36hg18NCBI36
Celera1520,982,083 - 20,984,249 (+)NCBICelera
Cytogenetic Map15q15.3NCBI
HuRef1520,915,481 - 20,917,649 (+)NCBIHuRef
CHM1_11544,210,872 - 44,213,040 (+)NCBICHM1_1
T2T-CHM13v2.01541,607,784 - 41,611,789 (+)NCBIT2T-CHM13v2.0
Hypk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,287,569 - 121,288,921 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,283,771 - 121,289,153 (+)EnsemblGRCm39 Ensembl
GRCm382121,457,088 - 121,458,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,453,290 - 121,458,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv372121,282,824 - 121,284,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,148,542 - 121,149,880 (+)NCBIMGSCv36mm8
Celera2122,607,878 - 122,609,227 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.39NCBI
Hypk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,888,709 - 128,890,089 (+)NCBIGRCr8
mRatBN7.23108,434,997 - 108,436,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,432,539 - 108,436,370 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,109,430 - 112,110,802 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,704,951 - 120,706,323 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,365,357 - 118,366,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,423,684 - 113,425,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,423,693 - 113,424,846 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,963,795 - 119,965,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,262,767 - 108,264,495 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,163,508 - 108,165,275 (+)NCBI
Celera3107,336,201 - 107,337,573 (+)NCBICelera
Cytogenetic Map3q35NCBI
Hypk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541610,258,612 - 10,259,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541610,258,357 - 10,259,699 (+)NCBIChiLan1.0ChiLan1.0
HYPK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21633,047,358 - 33,053,714 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11537,213,588 - 37,215,446 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,760,593 - 22,762,059 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,850,849 - 40,852,835 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,850,849 - 40,852,835 (+)Ensemblpanpan1.1panPan2
Hypk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,012,566 - 89,013,617 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,860,556 - 6,861,676 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,860,556 - 6,861,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYPK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12639,242,584 - 39,244,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048101,748,038 - 101,749,803 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hypk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480410,823,212 - 10,827,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in HYPK
20 total Variants

Expression


Sequence


RefSeq Acc Id: ENSCAFT00000021244   ⟹   ENSCAFP00000019727
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3010,543,289 - 10,544,569 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845046724   ⟹   ENSCAFP00845036663
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3010,677,228 - 10,680,914 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845046750   ⟹   ENSCAFP00845036681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3010,679,835 - 10,681,115 (+)Ensembl
RefSeq Acc Id: XM_038442176   ⟹   XP_038298104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03010,677,815 - 10,681,121 (+)NCBI
RefSeq Acc Id: XM_038516643   ⟹   XP_038372571
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13010,586,937 - 10,590,243 (+)NCBI
RefSeq Acc Id: XM_038580271   ⟹   XP_038436199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03010,828,600 - 10,831,906 (+)NCBI
RefSeq Acc Id: XM_038644552   ⟹   XP_038500480
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03010,708,866 - 10,712,172 (+)NCBI
RefSeq Acc Id: XM_544652   ⟹   XP_544652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13010,541,713 - 10,544,572 (+)NCBI
Dog10K_Boxer_Tasha3010,599,664 - 10,602,970 (+)NCBI
Sequence:
RefSeq Acc Id: XP_544652   ⟸   XM_544652
- UniProtKB: A0A8C0LDS9 (UniProtKB/TrEMBL),   A0A8I3PPP4 (UniProtKB/TrEMBL),   A0A8C0NFD9 (UniProtKB/TrEMBL),   A0A8P0NFF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000019727   ⟸   ENSCAFT00000021244
RefSeq Acc Id: XP_038372571   ⟸   XM_038516643
RefSeq Acc Id: XP_038500480   ⟸   XM_038644552
RefSeq Acc Id: XP_038298104   ⟸   XM_038442176
- UniProtKB: A0A8C0LDS9 (UniProtKB/TrEMBL),   A0A8I3PPP4 (UniProtKB/TrEMBL),   A0A8C0NFD9 (UniProtKB/TrEMBL),   A0A8P0NFF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436199   ⟸   XM_038580271
- UniProtKB: A0A8C0LDS9 (UniProtKB/TrEMBL),   A0A8C0NFD9 (UniProtKB/TrEMBL),   A0A8I3PPP4 (UniProtKB/TrEMBL),   A0A8P0NFF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845036681   ⟸   ENSCAFT00845046750
RefSeq Acc Id: ENSCAFP00845036663   ⟸   ENSCAFT00845046724

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000044459 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016371 UniProtKB/TrEMBL
  ENSCAFG00040020620 UniProtKB/TrEMBL
  ENSCAFG00845026509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021244.5 UniProtKB/TrEMBL
  ENSCAFT00030030151.1 UniProtKB/TrEMBL
  ENSCAFT00040038144.1 UniProtKB/TrEMBL
  ENSCAFT00845046724.1 UniProtKB/TrEMBL
  ENSCAFT00845046750 ENTREZGENE
  ENSCAFT00845046750.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro HYPK_UBA UniProtKB/TrEMBL
  NAC-like_UBA UniProtKB/TrEMBL
KEGG Report cfa:487528 UniProtKB/TrEMBL
NCBI Gene HYPK ENTREZGENE
PANTHER HUNTINGTIN-INTERACTING PROTEIN K UniProtKB/TrEMBL
  HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER UniProtKB/TrEMBL
Pfam HYPK_UBA UniProtKB/TrEMBL
UniProt A0A8C0LDS9 ENTREZGENE
  A0A8C0NFD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PPP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PZY6_CANLF UniProtKB/TrEMBL
  A0A8P0NFF9 ENTREZGENE
UniProt Secondary A0A8P0NFF9 UniProtKB/TrEMBL
VGNC ID VGNC:111527 ENTREZGENE