CLDN18 (claudin 18) - Rat Genome Database

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Gene: CLDN18 (claudin 18) Canis lupus familiaris
Analyze
Symbol: CLDN18
Name: claudin 18
RGD ID: 12260633
Description: ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: claudin-18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,229,115 - 34,257,431 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,228,992 - 34,255,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2334,213,722 - 34,242,091 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02334,761,006 - 34,789,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2334,761,122 - 34,787,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12334,442,928 - 34,471,295 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02334,508,337 - 34,536,789 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02334,759,409 - 34,787,779 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
asthma  (ISO)
megacolon  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CLDN18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,229,115 - 34,257,431 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,228,992 - 34,255,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2334,213,722 - 34,242,091 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02334,761,006 - 34,789,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2334,761,122 - 34,787,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12334,442,928 - 34,471,295 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02334,508,337 - 34,536,789 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02334,759,409 - 34,787,779 (+)NCBIUU_Cfam_GSD_1.0
CLDN18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383137,998,816 - 138,033,649 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3137,998,735 - 138,033,655 (+)EnsemblGRCh38hg38GRCh38
GRCh373137,717,658 - 137,752,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,200,348 - 139,235,184 (+)NCBINCBI36Build 36hg18NCBI36
Build 343139,211,703 - 139,235,192NCBI
Celera3136,142,326 - 136,177,157 (+)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3135,092,636 - 135,127,477 (+)NCBIHuRef
CHM1_13137,681,540 - 137,716,373 (+)NCBICHM1_1
T2T-CHM13v2.03140,739,479 - 140,774,309 (+)NCBIT2T-CHM13v2.0
Cldn18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,572,849 - 99,599,320 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl999,571,514 - 99,599,320 (-)EnsemblGRCm39 Ensembl
GRCm38999,690,796 - 99,717,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,689,461 - 99,717,267 (-)EnsemblGRCm38mm10GRCm38
MGSCv37999,591,218 - 99,610,434 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36999,500,151 - 99,519,367 (-)NCBIMGSCv36mm8
Celera999,227,315 - 99,246,562 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map952.0NCBI
Cldn18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88109,125,819 - 109,145,110 (-)NCBIGRCr8
mRatBN7.28100,246,499 - 100,265,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8100,247,633 - 100,273,351 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8105,917,684 - 105,935,375 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08104,116,986 - 104,134,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,959,520 - 101,977,211 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08107,933,725 - 107,960,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,934,860 - 107,952,530 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08107,357,500 - 107,384,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48104,560,892 - 104,578,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18104,580,347 - 104,597,768 (-)NCBI
Celera899,648,512 - 99,666,002 (-)NCBICelera
Cytogenetic Map8q31NCBI
Cldn18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501962,188 - 991,922 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955501962,188 - 991,922 (-)NCBIChiLan1.0ChiLan1.0
CLDN18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22135,915,550 - 135,936,176 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13135,914,811 - 135,943,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03135,037,555 - 135,061,105 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13142,478,031 - 142,512,548 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3142,478,031 - 142,512,548 (+)Ensemblpanpan1.1panPan2
Cldn18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560273,634,041 - 73,663,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936540373,889 - 401,535 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936540373,889 - 401,535 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1378,794,580 - 78,822,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11378,794,573 - 78,823,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21386,418,495 - 86,434,721 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11552,509,568 - 52,533,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1552,508,887 - 52,532,836 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604125,523,202 - 25,558,166 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473014,489,585 - 14,522,042 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473014,500,379 - 14,522,047 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CLDN18
330 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 4 3 3 5 1
Below cutoff 4 4 14 3 2 3 1 7 8 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022408667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022408668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038507741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038507742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038570982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038570983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038635176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038635177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_534274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_846964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000047849   ⟹   ENSCAFP00000039672
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2334,238,132 - 34,255,650 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000086812   ⟹   ENSCAFP00000053830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2334,228,992 - 34,255,650 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845041037   ⟹   ENSCAFP00845032153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2334,761,122 - 34,787,592 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845041084   ⟹   ENSCAFP00845032195
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2334,769,631 - 34,787,592 (+)Ensembl
RefSeq Acc Id: XM_038432439   ⟹   XP_038288367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02334,769,934 - 34,789,375 (+)NCBI
RefSeq Acc Id: XM_038432440   ⟹   XP_038288368
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02334,761,006 - 34,789,375 (+)NCBI
RefSeq Acc Id: XM_038507741   ⟹   XP_038363669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12334,451,856 - 34,471,295 (+)NCBI
RefSeq Acc Id: XM_038507742   ⟹   XP_038363670
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12334,442,928 - 34,471,295 (+)NCBI
RefSeq Acc Id: XM_038570982   ⟹   XP_038426910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02334,768,339 - 34,787,779 (+)NCBI
RefSeq Acc Id: XM_038570983   ⟹   XP_038426911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02334,759,409 - 34,787,779 (+)NCBI
RefSeq Acc Id: XM_038635176   ⟹   XP_038491104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02334,517,258 - 34,536,789 (+)NCBI
RefSeq Acc Id: XM_038635177   ⟹   XP_038491105
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02334,508,337 - 34,536,789 (+)NCBI
RefSeq Acc Id: XM_534274   ⟹   XP_534274
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12334,237,990 - 34,257,431 (+)NCBI
Dog10K_Boxer_Tasha2334,222,650 - 34,242,091 (+)NCBI
Sequence:
RefSeq Acc Id: XM_846964   ⟹   XP_852057
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12334,229,151 - 34,257,431 (+)NCBI
Dog10K_Boxer_Tasha2334,213,722 - 34,242,091 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_852057   ⟸   XM_846964
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TMZ8 (UniProtKB/TrEMBL),   A0A8I3PV36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_534274   ⟸   XM_534274
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N3B4 (UniProtKB/TrEMBL),   A0A8C0K2C0 (UniProtKB/TrEMBL),   A0A8I3PMY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053830   ⟸   ENSCAFT00000086812
RefSeq Acc Id: ENSCAFP00000039672   ⟸   ENSCAFT00000047849
RefSeq Acc Id: XP_038363670   ⟸   XM_038507742
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038363669   ⟸   XM_038507741
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038491105   ⟸   XM_038635177
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038491104   ⟸   XM_038635176
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288368   ⟸   XM_038432440
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TMZ8 (UniProtKB/TrEMBL),   A0A8I3PV36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038288367   ⟸   XM_038432439
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N3B4 (UniProtKB/TrEMBL),   A0A8C0K2C0 (UniProtKB/TrEMBL),   A0A8I3PMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038426911   ⟸   XM_038570983
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TMZ8 (UniProtKB/TrEMBL),   A0A8I3PV36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038426910   ⟸   XM_038570982
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K2C0 (UniProtKB/TrEMBL),   A0A8C0N3B4 (UniProtKB/TrEMBL),   A0A8I3PMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032195   ⟸   ENSCAFT00845041084
RefSeq Acc Id: ENSCAFP00845032153   ⟸   ENSCAFT00845041037


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000028766 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012114 UniProtKB/TrEMBL
  ENSCAFG00040024364 UniProtKB/TrEMBL
  ENSCAFG00845023238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047849.3 UniProtKB/TrEMBL
  ENSCAFT00000086812.2 UniProtKB/TrEMBL
  ENSCAFT00030022416.1 UniProtKB/TrEMBL
  ENSCAFT00030022460.1 UniProtKB/TrEMBL
  ENSCAFT00040045378.1 UniProtKB/TrEMBL
  ENSCAFT00040045388.1 UniProtKB/TrEMBL
  ENSCAFT00845041037 ENTREZGENE
  ENSCAFT00845041037.1 UniProtKB/TrEMBL
  ENSCAFT00845041084 ENTREZGENE
  ENSCAFT00845041084.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro Claudin UniProtKB/TrEMBL
  Claudin18 UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
KEGG Report cfa:477079 UniProtKB/TrEMBL
NCBI Gene CLDN18 ENTREZGENE
PANTHER PTHR12002 UniProtKB/TrEMBL
  PTHR12002:SF9 UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PRINTS CLAUDIN UniProtKB/TrEMBL
  CLAUDIN18 UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
UniProt A0A8C0K2C0 ENTREZGENE
  A0A8C0N3B4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TMZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PMY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PV36 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39314 ENTREZGENE