TMEM106B (transmembrane protein 106B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: TMEM106B (transmembrane protein 106B) Canis lupus familiaris
Analyze
Symbol: TMEM106B
Name: transmembrane protein 106B
RGD ID: 12251783
Description: ENCODES a protein that exhibits ATPase binding (inferred); INVOLVED IN lysosomal lumen acidification (ortholog); lysosomal protein catabolic process (ortholog); lysosomal transport (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Frontotemporal Lobar Degeneration (ortholog); genetic disease (ortholog); FOUND IN endosome (inferred); late endosome membrane (inferred); lysosomal membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11427,140,692 - 27,166,652 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1427,140,687 - 27,161,333 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1426,648,942 - 26,678,555 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01426,963,081 - 26,992,754 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1426,966,915 - 26,992,676 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11427,133,462 - 27,163,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01426,864,035 - 26,893,704 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01427,115,901 - 27,145,547 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TMEM106B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11427,140,692 - 27,166,652 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1427,140,687 - 27,161,333 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1426,648,942 - 26,678,555 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01426,963,081 - 26,992,754 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1426,966,915 - 26,992,676 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11427,133,462 - 27,163,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01426,864,035 - 26,893,704 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01427,115,901 - 27,145,547 (+)NCBIUU_Cfam_GSD_1.0
TMEM106B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38712,211,294 - 12,243,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl712,211,270 - 12,243,367 (+)EnsemblGRCh38hg38GRCh38
GRCh37712,250,920 - 12,282,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36712,217,451 - 12,243,411 (+)NCBINCBI36Build 36hg18NCBI36
Celera712,228,868 - 12,254,926 (+)NCBICelera
Cytogenetic Map7p21.3NCBI
HuRef712,126,997 - 12,153,058 (+)NCBIHuRef
CHM1_1712,251,533 - 12,277,588 (+)NCBICHM1_1
T2T-CHM13v2.0712,342,181 - 12,373,955 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2712,304,117 - 12,330,178 (+)NCBI
Tmem106b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39613,069,758 - 13,089,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl613,069,758 - 13,089,268 (+)EnsemblGRCm39 Ensembl
GRCm38613,069,759 - 13,089,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl613,069,759 - 13,089,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv37613,019,759 - 13,039,269 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36613,019,856 - 13,035,064 (+)NCBIMGSCv36mm8
Celera613,170,992 - 13,190,653 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map65.38NCBI
Tmem106b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8442,294,074 - 42,313,426 (+)NCBIGRCr8
mRatBN7.2441,328,125 - 41,347,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl441,327,994 - 41,345,619 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx446,306,388 - 46,323,231 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0442,232,496 - 42,249,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0440,636,118 - 40,652,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0439,517,679 - 39,534,491 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl439,517,548 - 39,535,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0439,352,537 - 39,371,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4438,398,245 - 38,415,059 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1438,516,785 - 38,533,599 (-)NCBI
Celera436,699,886 - 36,716,700 (+)NCBICelera
Cytogenetic Map4q21NCBI
Tmem106b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543218,619,413 - 18,639,151 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543218,619,418 - 18,644,876 (+)NCBIChiLan1.0ChiLan1.0
TMEM106B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2617,079,998 - 17,105,965 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1765,404,706 - 65,430,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0712,905,192 - 12,931,170 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1712,249,919 - 12,275,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl712,250,010 - 12,270,693 (+)Ensemblpanpan1.1panPan2
Tmem106b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511840,542,433 - 40,568,630 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367611,662,738 - 1,685,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367611,663,099 - 1,689,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM106B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl981,837,667 - 81,864,210 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1981,837,654 - 81,864,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2990,000,953 - 90,023,858 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM106B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12145,899,428 - 45,921,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2145,900,531 - 45,920,569 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604258,545,396 - 58,568,491 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem106b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248277,014,842 - 7,041,871 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248277,015,267 - 7,043,853 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM106B
340 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 17 1 1 1 6 12 10 4
Low 5 5 5 5 5 6 8 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003616   ⟹   ENSCAFP00000003346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1427,140,687 - 27,161,333 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044636   ⟹   ENSCAFP00845034971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1426,966,915 - 26,992,676 (+)Ensembl
RefSeq Acc Id: XM_038438069   ⟹   XP_038293997
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1426,648,942 - 26,678,555 (+)NCBI
RefSeq Acc Id: XM_038494670   ⟹   XP_038350598
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11427,133,462 - 27,163,103 (+)NCBI
RefSeq Acc Id: XM_038494671   ⟹   XP_038350599
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11427,137,164 - 27,163,103 (+)NCBI
RefSeq Acc Id: XM_038556954   ⟹   XP_038412882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01427,115,901 - 27,145,547 (+)NCBI
RefSeq Acc Id: XM_038556955   ⟹   XP_038412883
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01427,119,619 - 27,145,547 (+)NCBI
RefSeq Acc Id: XM_038620890   ⟹   XP_038476818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01426,864,035 - 26,893,704 (+)NCBI
RefSeq Acc Id: XM_038620891   ⟹   XP_038476819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01426,867,748 - 26,893,704 (+)NCBI
RefSeq Acc Id: XM_038686582   ⟹   XP_038542510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01426,963,081 - 26,992,754 (+)NCBI
RefSeq Acc Id: XM_038686583   ⟹   XP_038542511
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01426,966,796 - 26,992,754 (+)NCBI
RefSeq Acc Id: XM_539439   ⟹   XP_539439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11427,140,692 - 27,166,652 (+)NCBI
Dog10K_Boxer_Tasha1426,652,654 - 26,678,555 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_539439   ⟸   XM_539439
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NNS8 (UniProtKB/TrEMBL),   A0A8I3S576 (UniProtKB/TrEMBL),   A0A8C0KB23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000003346   ⟸   ENSCAFT00000003616
RefSeq Acc Id: XP_038350598   ⟸   XM_038494670
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038350599   ⟸   XM_038494671
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038476818   ⟸   XM_038620890
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038476819   ⟸   XM_038620891
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038542510   ⟸   XM_038686582
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KB23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038542511   ⟸   XM_038686583
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NNS8 (UniProtKB/TrEMBL),   A0A8I3S576 (UniProtKB/TrEMBL),   A0A8C0KB23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038293997   ⟸   XM_038438069
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KB23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412882   ⟸   XM_038556954
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KB23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412883   ⟸   XM_038556955
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KB23 (UniProtKB/TrEMBL),   A0A8C0NNS8 (UniProtKB/TrEMBL),   A0A8I3S576 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845034971   ⟸   ENSCAFT00845044636
Protein Domains
Transmembrane protein 106 C-terminal   Transmembrane protein 106 N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002306 Ensembl
  ENSCAFG00000058563 UniProtKB/TrEMBL
  ENSCAFG00030018410 UniProtKB/TrEMBL
  ENSCAFG00040017465 UniProtKB/TrEMBL
  ENSCAFG00845025296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000104380.1 UniProtKB/TrEMBL
  ENSCAFT00030033907.1 UniProtKB/TrEMBL
  ENSCAFT00040032276.1 UniProtKB/TrEMBL
  ENSCAFT00845044636 ENTREZGENE
  ENSCAFT00845044636.1 UniProtKB/TrEMBL
InterPro DUF1356_TMEM106 UniProtKB/TrEMBL
  TMEM106_C UniProtKB/TrEMBL
  TMEM106_N UniProtKB/TrEMBL
NCBI Gene TMEM106B ENTREZGENE
PANTHER PTHR28556 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 106B UniProtKB/TrEMBL
Pfam DUF1356 UniProtKB/TrEMBL
  TMEM106_N UniProtKB/TrEMBL
Superfamily-SCOP LEA14-like UniProtKB/TrEMBL
UniProt A0A8C0KB23 ENTREZGENE
  A0A8C0NNS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S576 ENTREZGENE, UniProtKB/TrEMBL