ABHD6 (abhydrolase domain containing 6, acylglycerol lipase) - Rat Genome Database

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Gene: ABHD6 (abhydrolase domain containing 6, acylglycerol lipase) Canis lupus familiaris
Analyze
Symbol: ABHD6
Name: abhydrolase domain containing 6, acylglycerol lipase
RGD ID: 12250129
Description: ENCODES a protein that exhibits acylglycerol lipase activity (inferred); catalytic activity (inferred); phospholipase activity (inferred); INVOLVED IN long-term synaptic depression (ortholog); negative regulation of cell migration (ortholog); regulation of endocannabinoid signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog); Pyruvate Dehydrogenase E1-Beta Deficiency (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: abhydrolase domain containing 6; monoacylglycerol lipase ABHD6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,301,120 - 32,331,030 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,302,104 - 32,330,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,230,178 - 32,271,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,573,573 - 32,614,688 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,573,597 - 32,614,474 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,029,624 - 32,070,713 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,386,128 - 32,427,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,557,760 - 32,599,072 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ABHD6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,301,120 - 32,331,030 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,302,104 - 32,330,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,230,178 - 32,271,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,573,573 - 32,614,688 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,573,597 - 32,614,474 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,029,624 - 32,070,713 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,386,128 - 32,427,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,557,760 - 32,599,072 (-)NCBIUU_Cfam_GSD_1.0
ABHD6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,237,792 - 58,294,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,237,532 - 58,295,693 (+)EnsemblGRCh38hg38GRCh38
GRCh37358,223,519 - 58,280,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,198,349 - 58,255,501 (+)NCBINCBI36Build 36hg18NCBI36
Build 34358,198,348 - 58,255,499NCBI
Celera358,237,772 - 58,295,009 (+)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,320,101 - 58,376,917 (+)NCBIHuRef
CHM1_1358,173,601 - 58,230,753 (+)NCBICHM1_1
T2T-CHM13v2.0358,278,191 - 58,335,141 (+)NCBIT2T-CHM13v2.0
Abhd6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,413,000 - 14,466,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,413,010 - 14,466,871 (-)EnsemblGRCm39 Ensembl
GRCm38148,002,888 - 8,056,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl148,002,902 - 8,056,763 (+)EnsemblGRCm38mm10GRCm38
MGSCv37148,835,416 - 8,889,069 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,794,781 - 6,848,434 (+)NCBIMGSCv36mm8
Celera143,626,234 - 3,679,797 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.69NCBI
Abhd6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,289,967 - 19,337,500 (-)NCBIGRCr8
mRatBN7.21516,859,740 - 16,907,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,859,738 - 16,906,985 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,034,098 - 19,081,627 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01519,992,574 - 20,040,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,247,481 - 18,295,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,647,903 - 18,695,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,647,844 - 18,695,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,614,361 - 22,661,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,846,512 - 18,894,003 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,846,513 - 18,894,003 (-)NCBI
Celera1516,815,723 - 16,863,221 (-)NCBICelera
Cytogenetic Map15p14NCBI
Abhd6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554301,808,924 - 1,861,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554301,809,969 - 1,861,441 (-)NCBIChiLan1.0ChiLan1.0
ABHD6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,207,823 - 58,262,962 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,212,597 - 58,267,740 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,172,334 - 58,227,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,586,537 - 59,641,824 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,586,573 - 59,641,824 (+)Ensemblpanpan1.1panPan2
Abhd6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,549,211 - 169,593,878 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,687,746 - 2,732,473 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,687,784 - 2,732,413 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1340,009,737 - 40,060,394 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,982,536 - 40,055,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,989,292 - 44,015,528 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABHD6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,530,543 - 19,593,083 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,542,161 - 19,582,310 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,247,753 - 147,302,666 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248225,336,427 - 5,376,721 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248225,332,197 - 5,376,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABHD6
372 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 13 1 6 12 2 4
Low 3 5 9 6 5 6 6 8 8 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038427356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_541828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000011854   ⟹   ENSCAFP00000010991
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2032,302,104 - 32,330,998 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036007   ⟹   ENSCAFP00845028180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2032,573,597 - 32,614,474 (-)Ensembl
RefSeq Acc Id: XM_038427356   ⟹   XP_038283284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02032,573,573 - 32,614,688 (-)NCBI
RefSeq Acc Id: XM_038455379   ⟹   XP_038311307
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2032,230,178 - 32,270,851 (-)NCBI
RefSeq Acc Id: XM_038455380   ⟹   XP_038311308
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2032,230,178 - 32,271,085 (-)NCBI
RefSeq Acc Id: XM_038455381   ⟹   XP_038311309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2032,230,178 - 32,270,852 (-)NCBI
RefSeq Acc Id: XM_038455382   ⟹   XP_038311310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2032,230,178 - 32,270,852 (-)NCBI
RefSeq Acc Id: XM_038503074   ⟹   XP_038359002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,029,624 - 32,070,363 (-)NCBI
RefSeq Acc Id: XM_038503075   ⟹   XP_038359003
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,029,624 - 32,070,713 (-)NCBI
RefSeq Acc Id: XM_038503076   ⟹   XP_038359004
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,029,624 - 32,070,366 (-)NCBI
RefSeq Acc Id: XM_038503077   ⟹   XP_038359005
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,029,624 - 32,070,365 (-)NCBI
RefSeq Acc Id: XM_038566043   ⟹   XP_038421971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02032,557,760 - 32,598,728 (-)NCBI
RefSeq Acc Id: XM_038566044   ⟹   XP_038421972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02032,557,760 - 32,599,072 (-)NCBI
RefSeq Acc Id: XM_038566045   ⟹   XP_038421973
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02032,557,760 - 32,598,731 (-)NCBI
RefSeq Acc Id: XM_038566046   ⟹   XP_038421974
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02032,557,760 - 32,598,730 (-)NCBI
RefSeq Acc Id: XM_038630187   ⟹   XP_038486115
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02032,386,128 - 32,427,061 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000010991   ⟸   ENSCAFT00000011854
RefSeq Acc Id: XP_038359003   ⟸   XM_038503075
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038359004   ⟸   XM_038503076
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038359005   ⟸   XM_038503077
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038359002   ⟸   XM_038503074
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038486115   ⟸   XM_038630187
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038283284   ⟸   XM_038427356
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PJU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038311308   ⟸   XM_038455380
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038311310   ⟸   XM_038455382
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038311309   ⟸   XM_038455381
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038311307   ⟸   XM_038455379
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421972   ⟸   XM_038566044
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421973   ⟸   XM_038566045
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421974   ⟸   XM_038566046
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421971   ⟸   XM_038566043
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KAX0 (UniProtKB/TrEMBL),   A0A8C0QJM1 (UniProtKB/TrEMBL),   A0A8I3PJU0 (UniProtKB/TrEMBL),   A0A8P0SCL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845028180   ⟸   ENSCAFT00845036007
Protein Domains
AB hydrolase-1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007394 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030020033 UniProtKB/TrEMBL
  ENSCAFG00040008770 UniProtKB/TrEMBL
  ENSCAFG00845020446 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011854.5 UniProtKB/TrEMBL
  ENSCAFT00030036779.1 UniProtKB/TrEMBL
  ENSCAFT00040016330.1 UniProtKB/TrEMBL
  ENSCAFT00845036007 ENTREZGENE
  ENSCAFT00845036007.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/TrEMBL
NCBI Gene ABHD6 ENTREZGENE
PANTHER MONOACYLGLYCEROL LIPASE UniProtKB/TrEMBL
  MONOACYLGLYCEROL LIPASE ABHD6 UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/TrEMBL
PRINTS ABHYDROLASE UniProtKB/TrEMBL
  EPOXHYDRLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0KAX0 ENTREZGENE
  A0A8C0QJM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PJU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SCL6 ENTREZGENE
UniProt Secondary A0A8P0SCL6 UniProtKB/TrEMBL
VGNC ID VGNC:37472 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-04 ABHD6  abhydrolase domain containing 6, acylglycerol lipase  ABHD6  abhydrolase domain containing 6  Symbol and/or name change 5135510 APPROVED