PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon) - Rat Genome Database

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Gene: PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon) Canis lupus familiaris
Analyze
Symbol: PPP2R5E
Name: protein phosphatase 2 regulatory subunit B'epsilon
RGD ID: 12243548
Description: ENCODES a protein that exhibits protein phosphatase activator activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN signal transduction (inferred); ASSOCIATED WITH Chromosomal Instability (ortholog); genetic disease (ortholog); Micronuclei, Chromosome-Defective (ortholog); FOUND IN cytosol (inferred); nucleus (inferred); protein phosphatase type 2A complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1837,945,350 - 38,088,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl837,945,331 - 38,088,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha837,663,916 - 37,780,994 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0838,172,395 - 38,314,626 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,172,672 - 38,314,720 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1837,789,055 - 37,931,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0837,868,630 - 38,004,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,221,858 - 38,364,575 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPP2R5E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1837,945,350 - 38,088,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl837,945,331 - 38,088,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha837,663,916 - 37,780,994 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0838,172,395 - 38,314,626 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,172,672 - 38,314,720 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1837,789,055 - 37,931,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0837,868,630 - 38,004,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,221,858 - 38,364,575 (-)NCBIUU_Cfam_GSD_1.0
PPP2R5E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381463,371,364 - 63,543,377 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1463,371,364 - 63,543,377 (-)EnsemblGRCh38hg38GRCh38
GRCh371463,838,082 - 64,010,095 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361462,911,108 - 63,079,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341462,911,107 - 63,079,832NCBI
Celera1443,892,051 - 44,060,782 (-)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1444,007,943 - 44,177,149 (-)NCBIHuRef
CHM1_11463,780,369 - 63,949,091 (-)NCBICHM1_1
T2T-CHM13v2.01457,578,735 - 57,750,775 (-)NCBIT2T-CHM13v2.0
Ppp2r5e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391275,496,237 - 75,643,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1275,497,655 - 75,643,019 (-)EnsemblGRCm39 Ensembl
GRCm381275,449,463 - 75,596,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1275,450,881 - 75,596,245 (-)EnsemblGRCm38mm10GRCm38
MGSCv371276,551,868 - 76,697,187 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361276,369,721 - 76,515,040 (-)NCBIMGSCv36mm8
Celera1276,535,179 - 76,696,642 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1232.75NCBI
Ppp2r5e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8699,904,569 - 100,053,672 (-)NCBIGRCr8
mRatBN7.2694,168,846 - 94,317,872 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,168,846 - 94,317,872 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx694,561,718 - 94,711,228 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0694,860,234 - 95,009,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,289,097 - 94,438,615 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0698,417,974 - 98,567,016 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl698,417,974 - 98,566,966 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06107,836,104 - 107,985,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,047,316 - 98,197,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,053,853 - 98,201,066 (-)NCBI
Celera692,596,832 - 92,745,242 (-)NCBICelera
Cytogenetic Map6q24NCBI
Ppp2r5e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554666,263,338 - 6,420,685 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554666,263,338 - 6,420,685 (+)NCBIChiLan1.0ChiLan1.0
PPP2R5E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21564,477,774 - 64,648,588 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11463,694,290 - 63,865,548 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01443,947,793 - 44,119,020 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11462,207,182 - 62,373,711 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1462,207,192 - 62,373,711 (-)Ensemblpanpan1.1panPan2
Ppp2r5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,818,311 - 66,961,292 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364957,230,786 - 7,372,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364957,230,405 - 7,372,525 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R5E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1194,505,025 - 194,656,164 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11194,505,535 - 194,653,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,594,665 - 216,628,082 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R5E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12440,548,986 - 40,730,451 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2440,553,635 - 40,633,392 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605328,759,264 - 28,930,715 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r5e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473437,510,255 - 37,675,482 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473437,509,711 - 37,678,807 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP2R5E
976 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 1 1 12 8 8
Low 5 5 11 6 5 6 5 6 2 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005623479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022422098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_537472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000036898   ⟹   ENSCAFP00000032325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl837,945,331 - 38,088,110 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061124   ⟹   ENSCAFP00000045063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl837,949,093 - 38,088,110 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067568   ⟹   ENSCAFP00000050295
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl837,946,863 - 38,087,743 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002601   ⟹   ENSCAFP00845002069
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl838,172,672 - 38,314,720 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002609   ⟹   ENSCAFP00845002076
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl838,172,896 - 38,314,720 (-)Ensembl
RefSeq Acc Id: XM_038483438   ⟹   XP_038339366
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1837,789,055 - 37,929,275 (-)NCBI
RefSeq Acc Id: XM_038483439   ⟹   XP_038339367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1837,789,055 - 37,931,745 (-)NCBI
RefSeq Acc Id: XM_038483440   ⟹   XP_038339368
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1837,789,055 - 37,931,647 (-)NCBI
RefSeq Acc Id: XM_038544898   ⟹   XP_038400826
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0838,221,858 - 38,362,097 (-)NCBI
RefSeq Acc Id: XM_038544899   ⟹   XP_038400827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0838,221,858 - 38,364,575 (-)NCBI
RefSeq Acc Id: XM_038544900   ⟹   XP_038400828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0838,221,858 - 38,364,477 (-)NCBI
RefSeq Acc Id: XM_038598252   ⟹   XP_038454180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha837,663,916 - 37,780,994 (-)NCBI
RefSeq Acc Id: XM_038609015   ⟹   XP_038464943
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0837,868,630 - 38,001,841 (-)NCBI
RefSeq Acc Id: XM_038609016   ⟹   XP_038464944
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0837,868,630 - 38,004,310 (-)NCBI
RefSeq Acc Id: XM_038609017   ⟹   XP_038464945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0837,868,630 - 38,004,207 (-)NCBI
RefSeq Acc Id: XM_038673822   ⟹   XP_038529750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0838,172,395 - 38,312,145 (-)NCBI
RefSeq Acc Id: XM_038673823   ⟹   XP_038529751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0838,172,395 - 38,314,626 (-)NCBI
RefSeq Acc Id: XM_038673824   ⟹   XP_038529752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0838,172,395 - 38,314,528 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000050295   ⟸   ENSCAFT00000067568
RefSeq Acc Id: ENSCAFP00000045063   ⟸   ENSCAFT00000061124
RefSeq Acc Id: ENSCAFP00000032325   ⟸   ENSCAFT00000036898
RefSeq Acc Id: XP_038339367   ⟸   XM_038483439
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038339368   ⟸   XM_038483440
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038339366   ⟸   XM_038483438
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038464944   ⟸   XM_038609016
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038464945   ⟸   XM_038609017
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038464943   ⟸   XM_038609015
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038529751   ⟸   XM_038673823
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P8R3 (UniProtKB/TrEMBL),   A0A8I3MG37 (UniProtKB/TrEMBL),   A0A8I3RRJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038529752   ⟸   XM_038673824
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P8R3 (UniProtKB/TrEMBL),   A0A8I3MG37 (UniProtKB/TrEMBL),   A0A8I3RRJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038529750   ⟸   XM_038673822
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RRJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038454180   ⟸   XM_038598252
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038400827   ⟸   XM_038544899
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P8R3 (UniProtKB/TrEMBL),   A0A8I3MG37 (UniProtKB/TrEMBL),   A0A8I3RRJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400828   ⟸   XM_038544900
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P8R3 (UniProtKB/TrEMBL),   A0A8I3MG37 (UniProtKB/TrEMBL),   A0A8I3RRJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400826   ⟸   XM_038544898
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RRJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845002069   ⟸   ENSCAFT00845002601
RefSeq Acc Id: ENSCAFP00845002076   ⟸   ENSCAFT00845002609


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015787 Ensembl
  ENSCAFG00030023977 UniProtKB/TrEMBL
  ENSCAFG00040006079 UniProtKB/TrEMBL
  ENSCAFG00845001510 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030044076.1 UniProtKB/TrEMBL
  ENSCAFT00030044134.1 UniProtKB/TrEMBL
  ENSCAFT00040011415.1 UniProtKB/TrEMBL
  ENSCAFT00845002601 ENTREZGENE
  ENSCAFT00845002601.1 UniProtKB/TrEMBL
  ENSCAFT00845002609.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  PP2A_B56 UniProtKB/TrEMBL
NCBI Gene PPP2R5E ENTREZGENE
PANTHER PTHR10257 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM UniProtKB/TrEMBL
Pfam B56 UniProtKB/TrEMBL
PIRSF PP2A_B56 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8C0P8R3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QML1_CANLF UniProtKB/TrEMBL
  A0A8I3MG37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RRJ5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44917 ENTREZGENE