MEGF8 (multiple EGF like domains 8) - Rat Genome Database

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Gene: MEGF8 (multiple EGF like domains 8) Canis lupus familiaris
Analyze
Symbol: MEGF8
Name: multiple EGF like domains 8
RGD ID: 12238168
Description: ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN aorta development (ortholog); BMP signaling pathway (ortholog); cell migration involved in gastrulation (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN membrane (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: multiple epidermal growth factor-like domains protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,020,344 - 112,063,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,021,960 - 112,024,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,446,973 - 111,489,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,633,280 - 112,675,963 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11112,187,654 - 112,230,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,823,244 - 111,865,891 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,750,119 - 112,792,669 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA,ISO)
nucleus  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MEGF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,020,344 - 112,063,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,021,960 - 112,024,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,446,973 - 111,489,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,633,280 - 112,675,963 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11112,187,654 - 112,230,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,823,244 - 111,865,891 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,750,119 - 112,792,669 (-)NCBIUU_Cfam_GSD_1.0
MEGF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,325,635 - 42,378,765 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,325,609 - 42,378,769 (+)EnsemblGRCh38hg38GRCh38
GRCh371942,829,787 - 42,882,917 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,521,601 - 47,574,761 (+)NCBINCBI36Build 36hg18NCBI36
Build 341947,532,797 - 47,573,778NCBI
Celera1939,630,557 - 39,683,710 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,259,903 - 39,313,054 (+)NCBIHuRef
CHM1_11942,831,424 - 42,884,572 (+)NCBICHM1_1
T2T-CHM13v2.01945,145,020 - 45,198,149 (+)NCBIT2T-CHM13v2.0
Megf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,016,589 - 25,065,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,016,589 - 25,065,342 (+)EnsemblGRCm39 Ensembl
GRCm38725,316,738 - 25,365,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,317,164 - 25,365,917 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,102,183 - 26,150,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,025,978 - 25,074,679 (+)NCBIMGSCv36mm8
Celera719,932,445 - 19,981,243 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.75NCBI
Megf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,030,057 - 90,079,423 (+)NCBIGRCr8
mRatBN7.2180,902,236 - 80,951,614 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,902,574 - 80,951,613 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,294,788 - 86,343,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,845,966 - 94,895,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,050,566 - 88,099,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,184,671 - 82,234,045 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,185,034 - 82,234,045 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,448,862 - 83,497,902 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,591,805 - 80,641,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,705,607 - 80,719,439 (+)NCBI
Celera175,345,442 - 75,394,666 (+)NCBICelera
Cytogenetic Map1q21NCBI
Megf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555548,416 - 591,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955555549,921 - 591,978 (-)NCBIChiLan1.0ChiLan1.0
MEGF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,430,431 - 48,483,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,299,206 - 50,352,593 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,213,339 - 39,265,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,805,307 - 47,858,636 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,805,307 - 47,858,636 (+)Ensemblpanpan1.1panPan2
Megf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,809,824 - 15,849,602 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706157,019 - 197,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706157,167 - 198,071 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEGF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,577,403 - 49,618,921 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,572,905 - 49,619,120 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,471,408 - 45,513,530 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEGF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,529,848 - 36,580,213 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,530,014 - 36,582,525 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,776,016 - 14,827,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Megf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907397,008 - 438,091 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907397,008 - 438,091 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MEGF8
599 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 7 1 12 1 1
Low 5 5 15 6 5 6 6 6 8 9 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014120042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038443584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000007776   ⟹   ENSCAFP00000007208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,021,960 - 112,024,773 (-)Ensembl
RefSeq Acc Id: XM_038443584   ⟹   XP_038299512
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1111,446,973 - 111,489,510 (-)NCBI
RefSeq Acc Id: XM_038467988   ⟹   XP_038323916
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11112,187,654 - 112,230,205 (-)NCBI
RefSeq Acc Id: XM_038528722   ⟹   XP_038384650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01112,750,119 - 112,792,668 (-)NCBI
RefSeq Acc Id: XM_038528724   ⟹   XP_038384652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01112,750,119 - 112,792,668 (-)NCBI
RefSeq Acc Id: XM_038528725   ⟹   XP_038384653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01112,750,119 - 112,792,669 (-)NCBI
RefSeq Acc Id: XM_038592998   ⟹   XP_038448926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01111,823,244 - 111,865,890 (-)NCBI
RefSeq Acc Id: XM_038592999   ⟹   XP_038448927
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01111,823,244 - 111,865,890 (-)NCBI
RefSeq Acc Id: XM_038593000   ⟹   XP_038448928
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01111,823,244 - 111,865,891 (-)NCBI
RefSeq Acc Id: XM_038656812   ⟹   XP_038512740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01112,633,280 - 112,675,963 (-)NCBI
RefSeq Acc Id: XM_038656813   ⟹   XP_038512741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01112,633,280 - 112,675,962 (-)NCBI
RefSeq Acc Id: XM_038656814   ⟹   XP_038512742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01112,633,280 - 112,675,963 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000007208   ⟸   ENSCAFT00000007776
RefSeq Acc Id: XP_038323916   ⟸   XM_038467988
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038448928   ⟸   XM_038593000
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038448927   ⟸   XM_038592999
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038448926   ⟸   XM_038592998
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512742   ⟸   XM_038656814
- Peptide Label: isoform X3
- UniProtKB: A0A8C0MBF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512740   ⟸   XM_038656812
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R0S5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512741   ⟸   XM_038656813
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R0S5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038299512   ⟸   XM_038443584
- Peptide Label: isoform X4
- UniProtKB: A0A8C0R0S5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384653   ⟸   XM_038528725
- Peptide Label: isoform X3
- UniProtKB: A0A8C0MBF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384652   ⟸   XM_038528724
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R0S5 (UniProtKB/TrEMBL),   A0A8C0RCB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384650   ⟸   XM_038528722
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R0S5 (UniProtKB/TrEMBL)
Protein Domains
CUB   EGF-like   Laminin EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004824 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004155 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007776.6 UniProtKB/TrEMBL
  ENSCAFT00030007663.1 UniProtKB/TrEMBL
  ENSCAFT00030008042.1 UniProtKB/TrEMBL
Gene3D-CATH Kelch-type beta propeller UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Spermadhesin, CUB domain UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  LE_dom UniProtKB/TrEMBL
  Plexin_repeat UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
NCBI Gene MEGF8 ENTREZGENE
PANTHER ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
  MULTIPLE EGF-LIKE-DOMAINS 8 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  Kelch_3 UniProtKB/TrEMBL
  Kelch_4 UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  Kelch motif UniProtKB/TrEMBL
  Spermadhesin, CUB domain UniProtKB/TrEMBL
UniProt A0A8C0MBF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R0S5 ENTREZGENE
  A0A8C0RCB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N7M7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43148 ENTREZGENE