GDA (guanine deaminase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: GDA (guanine deaminase) Canis lupus familiaris
Analyze
Symbol: GDA
Name: guanine deaminase
RGD ID: 12223934
Description: ENCODES a protein that exhibits guanine deaminase activity (ortholog); INVOLVED IN positive regulation of microtubule polymerization (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (ortholog); postsynapse (ortholog); postsynaptic cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,506,598 - 85,586,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,444,917 - 85,586,163 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,972,183 - 86,051,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,957,462 - 86,037,026 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,936,847 - 86,132,041 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,718,567 - 85,798,015 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0185,423,312 - 85,502,937 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,182,014 - 86,261,677 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,506,598 - 85,586,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,444,917 - 85,586,163 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,972,183 - 86,051,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,957,462 - 86,037,026 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,936,847 - 86,132,041 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,718,567 - 85,798,015 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0185,423,312 - 85,502,937 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,182,014 - 86,261,677 (-)NCBIUU_Cfam_GSD_1.0
GDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,114,608 - 72,259,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,114,595 - 72,257,193 (+)EnsemblGRCh38hg38GRCh38
GRCh37974,729,524 - 74,868,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36973,954,113 - 74,056,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 34971,993,846 - 72,096,693NCBI
Celera945,336,999 - 45,439,843 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef944,551,284 - 44,688,805 (+)NCBIHuRef
CHM1_1974,876,140 - 75,013,785 (+)NCBICHM1_1
T2T-CHM13v2.0984,265,431 - 84,411,245 (+)NCBIT2T-CHM13v2.0
Gda
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391921,368,671 - 21,450,025 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1921,368,671 - 21,450,809 (-)EnsemblGRCm39 Ensembl
GRCm381921,391,307 - 21,472,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1921,391,307 - 21,473,445 (-)EnsemblGRCm38mm10GRCm38
MGSCv371921,465,797 - 21,547,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361921,458,404 - 21,539,758 (-)NCBIMGSCv36mm8
Celera1922,118,313 - 22,200,564 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1914.32NCBI
Gda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81228,333,401 - 228,408,901 (-)NCBIGRCr8
mRatBN7.21218,903,045 - 218,982,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,906,815 - 218,982,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,355,381 - 227,430,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01234,291,943 - 234,367,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,109,969 - 227,185,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,982,542 - 239,057,663 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,982,392 - 239,057,732 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,267,039 - 246,345,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41224,579,794 - 224,655,298 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11224,743,773 - 224,819,377 (-)NCBI
Celera1216,146,233 - 216,221,719 (-)NCBICelera
Cytogenetic Map1q51NCBI
Gda
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955434983,388 - 1,049,948 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955434983,388 - 1,050,413 (-)NCBIChiLan1.0ChiLan1.0
GDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,339,465 - 71,442,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1971,345,407 - 71,448,550 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0952,559,752 - 52,662,886 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1970,891,615 - 70,994,574 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl970,891,319 - 70,994,574 (+)Ensemblpanpan1.1panPan2
Gda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,890,190 - 132,981,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,192,049 - 8,278,790 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365038,191,925 - 8,279,806 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,403,138 - 225,589,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,425,389 - 225,589,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,188,929 - 252,201,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,195,746 - 83,305,181 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,195,994 - 83,306,792 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603871,615,877 - 71,727,012 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gda
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624736836,286 - 914,409 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624736836,283 - 914,616 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GDA
881 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 1 10 5 2 5 6 6 10 6
Low 1 4 12 1 4 1 6 6
Below cutoff 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002853   ⟹   ENSCAFP00000002645
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl185,486,703 - 85,586,163 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000044098   ⟹   ENSCAFP00000038605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl185,444,917 - 85,586,163 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062376   ⟹   ENSCAFP00000059324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl185,509,171 - 85,586,163 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092760   ⟹   ENSCAFP00000057300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl185,509,171 - 85,586,163 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000120   ⟹   ENSCAFP00845000088
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,936,847 - 86,037,022 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000122   ⟹   ENSCAFP00845000090
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,936,860 - 86,037,022 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000125   ⟹   ENSCAFP00845000092
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,957,462 - 86,132,041 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000131   ⟹   ENSCAFP00845000097
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,957,462 - 86,037,072 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000136   ⟹   ENSCAFP00845000101
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,957,462 - 86,037,046 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000139   ⟹   ENSCAFP00845000104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,957,467 - 86,037,011 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000142   ⟹   ENSCAFP00845000107
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,958,884 - 86,037,054 (-)Ensembl
RefSeq Acc Id: XM_038466386   ⟹   XP_038322314
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1185,718,567 - 85,798,015 (-)NCBI
RefSeq Acc Id: XM_038527081   ⟹   XP_038383009
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0186,182,014 - 86,261,677 (-)NCBI
RefSeq Acc Id: XM_038591385   ⟹   XP_038447313
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0185,423,312 - 85,502,937 (-)NCBI
RefSeq Acc Id: XM_038655197   ⟹   XP_038511125
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0185,957,462 - 86,037,026 (-)NCBI
RefSeq Acc Id: XM_541285   ⟹   XP_541285
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1185,506,598 - 85,586,212 (-)NCBI
Dog10K_Boxer_Tasha185,972,183 - 86,051,720 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_541285   ⟸   XM_541285
- UniProtKB: A0A8C0PUH1 (UniProtKB/TrEMBL),   A0A8I3RQL8 (UniProtKB/TrEMBL),   A0A8I3M9U0 (UniProtKB/TrEMBL),   A0A8P0TB79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000057300   ⟸   ENSCAFT00000092760
RefSeq Acc Id: ENSCAFP00000038605   ⟸   ENSCAFT00000044098
RefSeq Acc Id: ENSCAFP00000059324   ⟸   ENSCAFT00000062376
RefSeq Acc Id: ENSCAFP00000002645   ⟸   ENSCAFT00000002853
RefSeq Acc Id: XP_038322314   ⟸   XM_038466386
RefSeq Acc Id: XP_038447313   ⟸   XM_038591385
RefSeq Acc Id: XP_038511125   ⟸   XM_038655197
- UniProtKB: A0A8C0PUH1 (UniProtKB/TrEMBL),   A0A8I3RQL8 (UniProtKB/TrEMBL),   A0A8I3M9U0 (UniProtKB/TrEMBL),   A0A8P0TB79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383009   ⟸   XM_038527081
- UniProtKB: A0A8C0PUH1 (UniProtKB/TrEMBL),   A0A8I3M9U0 (UniProtKB/TrEMBL),   A0A8I3RQL8 (UniProtKB/TrEMBL),   A0A8P0TB79 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000097   ⟸   ENSCAFT00845000131
RefSeq Acc Id: ENSCAFP00845000092   ⟸   ENSCAFT00845000125
RefSeq Acc Id: ENSCAFP00845000088   ⟸   ENSCAFT00845000120
RefSeq Acc Id: ENSCAFP00845000107   ⟸   ENSCAFT00845000142
RefSeq Acc Id: ENSCAFP00845000101   ⟸   ENSCAFT00845000136
RefSeq Acc Id: ENSCAFP00845000090   ⟸   ENSCAFT00845000122
RefSeq Acc Id: ENSCAFP00845000104   ⟸   ENSCAFT00845000139
Protein Domains
Amidohydrolase-related

Promoters
RGD ID:13682088
Promoter ID:EPDNEW_C155
Type:initiation region
Name:GDA_1
Description:guanine deaminase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1185,586,153 - 85,586,213EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001815 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022766 UniProtKB/TrEMBL
  ENSCAFG00040000416 UniProtKB/TrEMBL
  ENSCAFG00845000069 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002853.5 UniProtKB/TrEMBL
  ENSCAFT00000044098.4 UniProtKB/TrEMBL
  ENSCAFT00000062376.2 UniProtKB/TrEMBL
  ENSCAFT00000092760.2 UniProtKB/TrEMBL
  ENSCAFT00000100094.1 UniProtKB/TrEMBL
  ENSCAFT00000106817.1 UniProtKB/TrEMBL
  ENSCAFT00000108536.1 UniProtKB/TrEMBL
  ENSCAFT00030041853.1 UniProtKB/TrEMBL
  ENSCAFT00030041919.1 UniProtKB/TrEMBL
  ENSCAFT00040000708.1 UniProtKB/TrEMBL
  ENSCAFT00040000731.1 UniProtKB/TrEMBL
  ENSCAFT00845000120.1 UniProtKB/TrEMBL
  ENSCAFT00845000122.1 UniProtKB/TrEMBL
  ENSCAFT00845000125.1 UniProtKB/TrEMBL
  ENSCAFT00845000131.1 UniProtKB/TrEMBL
  ENSCAFT00845000136 ENTREZGENE
  ENSCAFT00845000136.1 UniProtKB/TrEMBL
  ENSCAFT00845000139.1 UniProtKB/TrEMBL
  ENSCAFT00845000142.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Guanine_deaminase UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
KEGG Report cfa:484169 UniProtKB/TrEMBL
NCBI Gene GDA ENTREZGENE
PANTHER GUANINE DEAMINASE UniProtKB/TrEMBL
  PTHR11271:SF6 UniProtKB/TrEMBL
Pfam Amidohydro_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
UniProt A0A8C0PUH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RRH4_CANLF UniProtKB/TrEMBL
  A0A8I3M9T3_CANLF UniProtKB/TrEMBL
  A0A8I3M9T9_CANLF UniProtKB/TrEMBL
  A0A8I3M9U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3M9W6_CANLF UniProtKB/TrEMBL
  A0A8I3MB80_CANLF UniProtKB/TrEMBL
  A0A8I3RNW8_CANLF UniProtKB/TrEMBL
  A0A8I3RQL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PIH5_CANLF UniProtKB/TrEMBL
  A0A8P0PMK3_CANLF UniProtKB/TrEMBL
  A0A8P0S7P4_CANLF UniProtKB/TrEMBL
  A0A8P0ST51_CANLF UniProtKB/TrEMBL
  A0A8P0TB79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TPH8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41154 ENTREZGENE