APOBEC3Z3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3) - Rat Genome Database

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Gene: APOBEC3Z3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3) Canis lupus familiaris
Analyze
Symbol: APOBEC3Z3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3
RGD ID: 12218214
Description: ENCODES a protein that exhibits cytidine deaminase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN clearance of foreign intracellular DNA (ortholog); hematopoietic progenitor cell differentiation (ortholog); negative regulation by host of viral genome replication (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Murine Acquired Immunodeficiency Syndrome (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA dC->dU-editing enzyme APOBEC-3H; DNA dC->dU-editing enzyme APOBEC-3Z3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,910,973 - 25,917,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,911,291 - 25,913,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,847,090 - 25,849,607 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha1025,855,423 - 25,859,260 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,663,787 - 26,694,303 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,663,787 - 26,676,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,403,345 - 26,407,577 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.11026,377,116 - 26,379,631 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,696,905 - 26,699,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,873,099 - 26,875,616 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APOBEC3Z3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,910,973 - 25,917,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,911,291 - 25,913,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,847,090 - 25,849,607 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha1025,855,423 - 25,859,260 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,663,787 - 26,694,303 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,663,787 - 26,676,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,403,345 - 26,407,577 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.11026,377,116 - 26,379,631 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,696,905 - 26,699,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,873,099 - 26,875,616 (-)NCBIUU_Cfam_GSD_1.0
APOBEC3H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,097,244 - 39,104,067 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,097,224 - 39,104,067 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,493,249 - 39,500,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,823,236 - 37,829,946 (+)NCBINCBI36Build 36hg18NCBI36
Celera2223,295,267 - 23,302,100 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,460,538 - 22,467,233 (+)NCBIHuRef
CHM1_12239,452,189 - 39,458,934 (+)NCBICHM1_1
T2T-CHM13v2.02239,567,663 - 39,574,409 (+)NCBIT2T-CHM13v2.0
Apobec3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,774,620 - 79,802,419 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,775,860 - 79,800,107 (+)EnsemblGRCm39 Ensembl
GRCm381579,892,058 - 79,918,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,891,659 - 79,915,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,722,838 - 79,738,859 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,719,713 - 79,735,341 (+)NCBIMGSCv36mm8
Celera1582,011,222 - 82,026,327 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Apobec3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,314,196 - 113,333,306 (+)NCBIGRCr8
mRatBN7.27111,433,789 - 111,453,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,433,764 - 111,452,922 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,181,634 - 113,200,966 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,405,176 - 115,424,510 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,374,524 - 115,393,857 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,108,108 - 121,128,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,109,241 - 121,128,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,099,574 - 121,118,684 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,121,580 - 118,140,691 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,145,775 - 118,174,915 (+)NCBI
Celera7107,763,814 - 107,782,772 (+)NCBICelera
Cytogenetic Map7q34NCBI
APOBEC3H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,947,853 - 48,952,770 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,639,344 - 51,642,634 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,003,585 - 20,010,741 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,821,315 - 37,828,153 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,821,315 - 37,828,153 (+)Ensemblpanpan1.1panPan2
APOBEC3H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,734,362 - 21,749,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,742,084 - 21,749,288 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045104,008,482 - 104,015,525 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in APOBEC3Z3
55 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 13 3 6 3 6 6 8 5
Below cutoff 5 9 3 3 6 6 8 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002105   ⟹   ENSCAFP00000001949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1025,911,291 - 25,913,808 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845039248   ⟹   ENSCAFP00845030740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1026,663,787 - 26,666,304 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845039278   ⟹   ENSCAFP00845030766
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1026,664,403 - 26,672,701 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845039344   ⟹   ENSCAFP00845030826
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1026,671,247 - 26,676,218 (-)Ensembl
RefSeq Acc Id: NM_001346130   ⟹   NP_001333059
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11025,911,291 - 25,913,808 (-)NCBI
Dog10K_Boxer_Tasha1025,847,090 - 25,849,607 (-)NCBI
ROS_Cfam_1.01026,663,787 - 26,666,304 (-)NCBI
UMICH_Zoey_3.11026,377,116 - 26,379,631 (-)NCBI
UNSW_CanFamBas_1.01026,696,905 - 26,699,422 (-)NCBI
UU_Cfam_GSD_1.01026,873,099 - 26,875,616 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038488589   ⟹   XP_038344517
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11026,403,345 - 26,407,577 (-)NCBI
RefSeq Acc Id: XM_038643344   ⟹   XP_038499272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1025,855,423 - 25,859,260 (-)NCBI
RefSeq Acc Id: XM_038678789   ⟹   XP_038534717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01026,664,401 - 26,694,303 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001333059   ⟸   NM_001346130
- UniProtKB: A0A7R6SZJ1 (UniProtKB/TrEMBL),   A0A8C0NNU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001949   ⟸   ENSCAFT00000002105
RefSeq Acc Id: XP_038344517   ⟸   XM_038488589
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038534717   ⟸   XM_038678789
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038499272   ⟸   XM_038643344
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCAFP00845030740   ⟸   ENSCAFT00845039248
RefSeq Acc Id: ENSCAFP00845030766   ⟸   ENSCAFT00845039278
RefSeq Acc Id: ENSCAFP00845030826   ⟸   ENSCAFT00845039344
Protein Domains
CMP/dCMP-type deaminase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001361 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017337 UniProtKB/TrEMBL
  ENSCAFG00040006218 UniProtKB/TrEMBL
  ENSCAFG00845022251 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002105.5 UniProtKB/TrEMBL
  ENSCAFT00000096411.1 UniProtKB/TrEMBL
  ENSCAFT00000103938.1 UniProtKB/TrEMBL
  ENSCAFT00030031946.1 UniProtKB/TrEMBL
  ENSCAFT00030031986.1 UniProtKB/TrEMBL
  ENSCAFT00040011584.1 UniProtKB/TrEMBL
  ENSCAFT00040011598.1 UniProtKB/TrEMBL
  ENSCAFT00845039248 ENTREZGENE
  ENSCAFT00845039248.1 UniProtKB/TrEMBL
  ENSCAFT00845039278.1 UniProtKB/TrEMBL
  ENSCAFT00845039344.1 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/TrEMBL
  CMP_dCMP_dom UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/TrEMBL
NCBI Gene APOBEC3Z3 ENTREZGENE
PANTHER DNA DC-DU-EDITING ENZYME APOBEC-3F UniProtKB/TrEMBL
  DNA DC-DU-EDITING ENZYME APOBEC-3H UniProtKB/TrEMBL
  MRNA EDITING ENZYME UniProtKB/TrEMBL
Pfam APOBEC2 UniProtKB/TrEMBL
  NAD1 UniProtKB/TrEMBL
PROSITE CYT_DCMP_DEAMINASES_1 UniProtKB/TrEMBL
  CYT_DCMP_DEAMINASES_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53927 UniProtKB/TrEMBL
UniProt A0A7R6SZJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NM21_CANLF UniProtKB/TrEMBL
  A0A8C0NNU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PAX3_CANLF UniProtKB/TrEMBL
  A0A8I3PB24_CANLF UniProtKB/TrEMBL
  A0A8P0PKT8_CANLF UniProtKB/TrEMBL
  A0A8P0PL77_CANLF UniProtKB/TrEMBL