GMPR2 (guanosine monophosphate reductase 2)

Gene: GMPR2 (guanosine monophosphate reductase 2) Canis lupus familiaris

Analyze

Symbol:

GMPR2

Name:

guanosine monophosphate reductase 2

RGD ID:

12201489

Description:

ENCODES a protein that exhibits GMP reductase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN GMP metabolic process (inferred); nucleotide metabolic process (inferred); purine nucleobase metabolic process (inferred); ASSOCIATED WITH adenocarcinoma (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); dyskeratosis congenita (ortholog); FOUND IN GMP reductase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GMP reductase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,213,238 - 4,220,740 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,213,373 - 4,220,740 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,134,799 - 4,142,420 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,323,889 - 4,331,513 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,324,117 - 4,331,509 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,014,274 - 4,021,895 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,076,063 - 4,083,696 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,338,401 - 4,346,026 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

dyskeratosis congenita (ISO)

lysinuric protein intolerance (ISO)

Specific Granule Deficiency (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

GMP metabolic process (IEA)

nucleotide metabolic process (IEA)

purine nucleobase metabolic process (IEA)

purine nucleotide metabolic process (IEA)

Cellular Component

GMP reductase complex (IEA)

Molecular Function

GMP reductase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

GMPR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,213,238 - 4,220,740 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,213,373 - 4,220,740 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,134,799 - 4,142,420 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,323,889 - 4,331,513 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,324,117 - 4,331,509 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,014,274 - 4,021,895 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,076,063 - 4,083,696 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,338,401 - 4,346,026 (+)	NCBI		UU_Cfam_GSD_1.0

GMPR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,232,622 - 24,239,242 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,232,422 - 24,239,242 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,701,828 - 24,708,448 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,771,488 - 23,778,288 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,771,942 - 23,778,285	NCBI
Celera	14	4,566,286 - 4,573,086 (+)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,816,418 - 4,823,218 (+)	NCBI		HuRef
CHM1_1	14	24,700,271 - 24,707,071 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,430,995 - 18,437,615 (+)	NCBI		T2T-CHM13v2.0

Gmpr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,909,692 - 55,935,602 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,909,398 - 55,916,657 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,672,235 - 55,687,861 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,671,941 - 55,679,200 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,291,072 - 56,297,588 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,626,307 - 54,633,271 (+)	NCBI		MGSCv36	mm8
Celera	14	53,477,308 - 53,483,824 (+)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Gmpr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,135,455 - 33,144,923 (+)	NCBI		GRCr8
mRatBN7.2	15	29,165,421 - 29,175,933 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,165,783 - 29,174,935 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	31,011,501 - 31,020,661 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,158,722 - 32,167,882 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,401,065 - 30,410,221 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,352,857 - 34,362,074 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,352,914 - 34,362,032 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,242,834 - 38,252,051 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,820,865 - 33,830,025 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,836,608 - 33,840,631 (+)	NCBI
Celera	15	28,742,209 - 28,751,367 (+)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

Gmpr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	36,166,129 - 36,173,245 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	36,166,129 - 36,173,247 (-)	NCBI	ChiLan1.0	ChiLan1.0

GMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,586,650 - 25,594,233 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,803,398 - 24,810,725 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,008,664 - 5,015,461 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,132,227 - 23,139,044 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,132,227 - 23,139,044 (+)	Ensembl	panpan1.1		panPan2

Gmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,058,339 - 36,065,069 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936722	323,917 - 330,648 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMPR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,060,676 - 75,070,084 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,060,680 - 75,070,079 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,331,603 - 80,340,768 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GMPR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,215,137 - 1,222,219 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,215,357 - 1,225,716 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,899,552 - 12,906,635 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gmpr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,312,386 - 8,319,799 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,312,253 - 8,319,585 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GMPR2
40 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5		16		6		6		12		10	6
Low		5	6	6		6		6		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014115787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038482857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038482858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038482859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038544289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038544290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038544291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038608408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038608409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038608410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038673216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038673217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038673218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_845034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000019320 ⟹ ENSCAFP00000017919

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,213,373 - 4,220,740 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000061970 ⟹ ENSCAFP00000052575

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,213,373 - 4,220,740 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845011305 ⟹ ENSCAFP00845008822

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,324,117 - 4,331,509 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845011334 ⟹ ENSCAFP00845008849

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,324,117 - 4,331,509 (+)	Ensembl

RefSeq Acc Id:

XM_014115787 ⟹ XP_013971262

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	8	4,213,571 - 4,220,733 (+)	NCBI
Dog10K_Boxer_Tasha	8	4,135,264 - 4,142,414 (+)	NCBI

Sequence:

show sequence

AACTAATTGTGGGAATACGCCCCCTATTCCTACTCACCCCCAAATCATCTTACCCCGAATTGGT
CTTTGAAAGGGTATAAGGAAGAGTAGTGGGAGCAAGGAATGCACATTTTTGGGGTCATTCACGA
CTCCATCCTAATTCTCCCCAACAAATAGTACCTGGGACGGAAATACCACGGTTTTCAGATCTGT
TGCTACCCCAAGGTCCCCACCATGCCTCACATCGACAGTGACATCAAACTGGACTTCAAGGATG
TCTTGTTGAGGCCCAAACGCAGTACCCTTAAGTCTCGAAGTGAGGTGGATCTCACAAGATCCTT
TTCATTTCGGAACTCAAAGCAGGTGTACACTGGGATCCCCATCATTGCTGCCAACATGGATACT
GTGGGCACCTTTGAGATGGCCAAGGTTCTCTGTAAGTTCTCCCTCTTCACAGCTGTCCATAAAC
ACTACAGCCTCCAGCAGTGGAAAGAATTTGCTAGCCAGAATCCTGACTGTCTTGAGCATTTAGC
TGCCAGCTCAGGCACAGGCTCTTCGGACTTTGAGCAGCTGGAACAGATCCTGGAAGCTATTCCC
CAGGTGAAATATATATGCCTGGACGTGGCAAACGGCTACTCTGAACACTTTGTTGAGTTTGTAA
AGGATGTGCGGAAGCGCTTCCCCGAACACACCATCATGGCAGGGAATGTAGTAACAGGAGAGAT
GGTGGAAGAGCTGATCCTATCTGGGGCTGATATCATCAAAGTGGGAATCGGACCAGGCTCTGTG
TGCACCACCCGGAAGAAAACTGGAGTGGGGTACCCACAGCTCAGTGCAGTGATGGAGTGTGCAG
ATGCTGCTCATGGCCTCAAGGGCCACATCATTTCAGATGGAGGCTGCAGCTGTCCTGGGGATGT
GGCCAAGGCTTTCGGGGCAGGAGCTGACTTTGTGATGCTGGGTGGCATGCTGGCTGGGCACAGT
GAATCAGGTGGTGAGCTCATTGAGAGAGATGGCAAGAAGTACAAGCTCTTTTATGGGATGAGTT
CTGAAATGGCCATGAAGAAGTATGCTGGGGGAGTGGCTGAGTACAGGGCCTCAGAGGGAAAGAC
GGTGGAGGTGCCCTTTAAAGGGGATGTGGAACATACCATCCGAGACATCCTTGGAGGCATCCGC
TCCACATGTACCTACGTGGGAGCAGCTAAACTGAAGGAGTTGAGCCGGAGAACCACCTTCATCC
GGGTCACCCAGCAGGTGAATCCAATCTTCAGTGATGAGAGCTAGACCTGAGCAGCTGTGCCCTC
TCAAGGCACTAGCACCTCCCAAGTGGGTTCCTCACCCATCCGAACTACTATGGCTATTTATCAC
TCAGTCATTTCCAGTTGTCTCACTGCTGAGGGCTCCTGCAGTAATTCTGTACTCTGTACACACA
TAATGCCCAGGGCACACACTGGGGAGGAAGCGAGGCAGCCAAGCTAAGAAAATGAAGACAGTCA
AATGCACACTGGGGACCCAGCATCCTGAAGATTATTAAAAGGAAAAGATGCTGGTTCCTATCTA
GGTGTTTAATGTGGCTTTGATCTGGAAGAGTTAGGCTCTTGAAATCATGTTTTGGTAATGAGCT
TCATTAAATAGGAGCTTTGAATACCTAAAAAGCTCAGAAGTGTTGACGCATTTTAAATATCTCA
ATAAAGAGACCTCAGTGA

hide sequence

RefSeq Acc Id:

XM_038482857 ⟹ XP_038338785

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	8	4,014,276 - 4,021,895 (+)	NCBI

RefSeq Acc Id:

XM_038482858 ⟹ XP_038338786

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	8	4,014,738 - 4,021,895 (+)	NCBI

RefSeq Acc Id:

XM_038482859 ⟹ XP_038338787

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	8	4,014,274 - 4,021,895 (+)	NCBI

RefSeq Acc Id:

XM_038544289 ⟹ XP_038400217

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	8	4,338,402 - 4,346,026 (+)	NCBI

RefSeq Acc Id:

XM_038544290 ⟹ XP_038400218

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	8	4,338,866 - 4,346,020 (+)	NCBI

RefSeq Acc Id:

XM_038544291 ⟹ XP_038400219

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	8	4,338,401 - 4,346,020 (+)	NCBI

RefSeq Acc Id:

XM_038584049 ⟹ XP_038439977

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	8	4,134,799 - 4,142,414 (+)	NCBI

RefSeq Acc Id:

XM_038608408 ⟹ XP_038464336

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	8	4,076,064 - 4,083,696 (+)	NCBI

RefSeq Acc Id:

XM_038608409 ⟹ XP_038464337

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	8	4,076,535 - 4,083,696 (+)	NCBI

RefSeq Acc Id:

XM_038608410 ⟹ XP_038464338

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	8	4,076,063 - 4,083,696 (+)	NCBI

RefSeq Acc Id:

XM_038673216 ⟹ XP_038529144

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	8	4,323,890 - 4,331,513 (+)	NCBI

RefSeq Acc Id:

XM_038673217 ⟹ XP_038529145

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	8	4,324,354 - 4,331,507 (+)	NCBI

RefSeq Acc Id:

XM_038673218 ⟹ XP_038529146

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	8	4,323,889 - 4,331,507 (+)	NCBI

RefSeq Acc Id:

XM_845034 ⟹ XP_850127

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	8	4,213,238 - 4,220,740 (+)	NCBI
Dog10K_Boxer_Tasha	8	4,134,800 - 4,142,420 (+)	NCBI

Sequence:

show sequence

GAGCCGGGGCTTGGAAAGCGGGGTCGAAACGAACTACTTCTCCCGTCATGCCAGGGGACAGCTC
CACCCGCTCCACCCTGGGAGTCGTAGTCTTCCGCCCCTCGGATCCGACTGCAAGCTCGGTGTGT
GAACCCTGTTACCCAGAAGACCGCGCACTGCCGCTGCCGAAACCGGGATTCTCCAATTAATCCT
TACCGCCCGCATTTAGCGGAACGTGTTGGCACGGCCCACAAGGCTCTGCGGGGCTGCACGAGGC
TAGTTGCTAAGCAAGGGCTACTGTGGTCAACTGCCGCCCGGGCCACGGCGACAGGAATTTTCAG
ATCTGTTGCTACCCCAAGGTCCCCACCATGCCTCACATCGACAGTGACATCAAACTGGACTTCA
AGGATGTCTTGTTGAGGCCCAAACGCAGTACCCTTAAGTCTCGAAGTGAGGTGGATCTCACAAG
ATCCTTTTCATTTCGGAACTCAAAGCAGGTGTACACTGGGATCCCCATCATTGCTGCCAACATG
GATACTGTGGGCACCTTTGAGATGGCCAAGGTTCTCTGTAAGTTCTCCCTCTTCACAGCTGTCC
ATAAACACTACAGCCTCCAGCAGTGGAAAGAATTTGCTAGCCAGAATCCTGACTGTCTTGAGCA
TTTAGCTGCCAGCTCAGGCACAGGCTCTTCGGACTTTGAGCAGCTGGAACAGATCCTGGAAGCT
ATTCCCCAGGTGAAATATATATGCCTGGACGTGGCAAACGGCTACTCTGAACACTTTGTTGAGT
TTGTAAAGGATGTGCGGAAGCGCTTCCCCGAACACACCATCATGGCAGGGAATGTAGTAACAGG
AGAGATGGTGGAAGAGCTGATCCTATCTGGGGCTGATATCATCAAAGTGGGAATCGGACCAGGC
TCTGTGTGCACCACCCGGAAGAAAACTGGAGTGGGGTACCCACAGCTCAGTGCAGTGATGGAGT
GTGCAGATGCTGCTCATGGCCTCAAGGGCCACATCATTTCAGATGGAGGCTGCAGCTGTCCTGG
GGATGTGGCCAAGGCTTTCGGGGCAGGAGCTGACTTTGTGATGCTGGGTGGCATGCTGGCTGGG
CACAGTGAATCAGGTGGTGAGCTCATTGAGAGAGATGGCAAGAAGTACAAGCTCTTTTATGGGA
TGAGTTCTGAAATGGCCATGAAGAAGTATGCTGGGGGAGTGGCTGAGTACAGGGCCTCAGAGGG
AAAGACGGTGGAGGTGCCCTTTAAAGGGGATGTGGAACATACCATCCGAGACATCCTTGGAGGC
ATCCGCTCCACATGTACCTACGTGGGAGCAGCTAAACTGAAGGAGTTGAGCCGGAGAACCACCT
TCATCCGGGTCACCCAGCAGGTGAATCCAATCTTCAGTGATGAGAGCTAGACCTGAGCAGCTGT
GCCCTCTCAAGGCACTAGCACCTCCCAAGTGGGTTCCTCACCCATCCGAACTACTATGGCTATT
TATCACTCAGTCATTTCCAGTTGTCTCACTGCTGAGGGCTCCTGCAGTAATTCTGTACTCTGTA
CACACATAATGCCCAGGGCACACACTGGGGAGGAAGCGAGGCAGCCAAGCTAAGAAAATGAAGA
CAGTCAAATGCACACTGGGGACCCAGCATCCTGAAGATTATTAAAAGGAAAAGATGCTGGTTCC
TATCTAGGTGTTTAATGTGGCTTTGATCTGGAAGAGTTAGGCTCTTGAAATCATGTTTTGGTAA
TGAGCTTCATTAAATAGGAGCTTTGAATACCTAAAAAGCTCAGAAGTGTTGACGCATTTTAAAT
ATCTCAATAAAGAGACCTCAGTGACTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013971262	(Get FASTA)	NCBI Sequence Viewer
	XP_038338785	(Get FASTA)	NCBI Sequence Viewer
	XP_038338786	(Get FASTA)	NCBI Sequence Viewer
	XP_038338787	(Get FASTA)	NCBI Sequence Viewer
	XP_038400217	(Get FASTA)	NCBI Sequence Viewer
	XP_038400218	(Get FASTA)	NCBI Sequence Viewer
	XP_038400219	(Get FASTA)	NCBI Sequence Viewer
	XP_038439977	(Get FASTA)	NCBI Sequence Viewer
	XP_038464336	(Get FASTA)	NCBI Sequence Viewer
	XP_038464337	(Get FASTA)	NCBI Sequence Viewer
	XP_038464338	(Get FASTA)	NCBI Sequence Viewer
	XP_038529144	(Get FASTA)	NCBI Sequence Viewer
	XP_038529145	(Get FASTA)	NCBI Sequence Viewer
	XP_038529146	(Get FASTA)	NCBI Sequence Viewer
	XP_850127	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000017919.3
	ENSCAFP00000052575.1
	ENSCAFP00030023429.1
	ENSCAFP00030023500.1
	ENSCAFP00030023592.1
	ENSCAFP00030023669.1
	ENSCAFP00040006624.1
	ENSCAFP00040006632.1
	ENSCAFP00845008822
	ENSCAFP00845008822.1
	ENSCAFP00845008849.1

RefSeq Acc Id:

XP_850127 ⟸ XM_845034

- UniProtKB:

A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPHIDSDIKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQVYTGIPIIAANMDTVGTFEMA
KVLCKFSLFTAVHKHYSLQQWKEFASQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICL
DVANGYSEHFVEFVKDVRKRFPEHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKT
GVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELI
ERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVG
AAKLKELSRRTTFIRVTQQVNPIFSDES

hide sequence

RefSeq Acc Id:

XP_013971262 ⟸ XM_014115787

- UniProtKB:

A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPHIDSDIKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQVYTGIPIIAANMDTVGTFEMA
KVLCKFSLFTAVHKHYSLQQWKEFASQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICL
DVANGYSEHFVEFVKDVRKRFPEHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKT
GVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELI
ERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVG
AAKLKELSRRTTFIRVTQQVNPIFSDES

hide sequence

RefSeq Acc Id:

ENSCAFP00000017919 ⟸ ENSCAFT00000019320

RefSeq Acc Id:

ENSCAFP00000052575 ⟸ ENSCAFT00000061970

RefSeq Acc Id:

XP_038338787 ⟸ XM_038482859

RefSeq Acc Id:

XP_038338785 ⟸ XM_038482857

RefSeq Acc Id:

XP_038338786 ⟸ XM_038482858

RefSeq Acc Id:

XP_038464338 ⟸ XM_038608410

RefSeq Acc Id:

XP_038464336 ⟸ XM_038608408

RefSeq Acc Id:

XP_038464337 ⟸ XM_038608409

RefSeq Acc Id:	XP_038529146 ⟸ XM_038673218
- UniProtKB:	A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038529144 ⟸ XM_038673216
- UniProtKB:	A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038529145 ⟸ XM_038673217
- UniProtKB:	A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038439977 ⟸ XM_038584049
- UniProtKB:	A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038400219 ⟸ XM_038544291
- UniProtKB:	A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL), A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038400217 ⟸ XM_038544289
- UniProtKB:	A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL), A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038400218 ⟸ XM_038544290
- UniProtKB:	A0A8C0JQF4 (UniProtKB/TrEMBL), A0A8C0NC15 (UniProtKB/TrEMBL), A0A8C0NPE4 (UniProtKB/TrEMBL), A0A8I3N2R6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845008849 ⟸ ENSCAFT00845011334

RefSeq Acc Id:

ENSCAFP00845008822 ⟸ ENSCAFT00845011305

Protein Domains

IMP dehydrogenase/GMP reductase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000012127	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030014458	UniProtKB/TrEMBL
	ENSCAFG00040003975	UniProtKB/TrEMBL
	ENSCAFG00845006349	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000019320.5	UniProtKB/TrEMBL
	ENSCAFT00000061970.2	UniProtKB/TrEMBL
	ENSCAFT00030026845.1	UniProtKB/TrEMBL
	ENSCAFT00030026928.1	UniProtKB/TrEMBL
	ENSCAFT00030027027.1	UniProtKB/TrEMBL
	ENSCAFT00030027118.1	UniProtKB/TrEMBL
	ENSCAFT00040007595.1	UniProtKB/TrEMBL
	ENSCAFT00040007603.1	UniProtKB/TrEMBL
	ENSCAFT00845011305	ENTREZGENE
	ENSCAFT00845011305.1	UniProtKB/TrEMBL
	ENSCAFT00845011334.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/TrEMBL
	GMPR	UniProtKB/TrEMBL
	IMP_DH/GMP_Rdtase_CS	UniProtKB/TrEMBL
	IMP_DH_GMPRt	UniProtKB/TrEMBL
KEGG Report	cfa:480266	UniProtKB/TrEMBL
NCBI Gene	GMPR2	ENTREZGENE
PANTHER	GMP REDUCTASE	UniProtKB/TrEMBL
	GMP REDUCTASE 2	UniProtKB/TrEMBL
Pfam	IMPDH	UniProtKB/TrEMBL
PIRSF	GMP_reductase	UniProtKB/TrEMBL
PROSITE	IMP_DH_GMP_RED	UniProtKB/TrEMBL
SMART	IMPDH	UniProtKB/TrEMBL
Superfamily-SCOP	Inosine monophosphate dehydrogenase (IMPDH)	UniProtKB/TrEMBL
UniProt	A0A8C0JQF4	ENTREZGENE
	A0A8C0N935_CANLF	UniProtKB/TrEMBL
	A0A8C0NC15	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0NCM1_CANLF	UniProtKB/TrEMBL
	A0A8C0NPE4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MXM3_CANLF	UniProtKB/TrEMBL
	A0A8I3N2R6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:41295	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD