SHANK1 (SH3 and multiple ankyrin repeat domains 1) - Rat Genome Database

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Gene: SHANK1 (SH3 and multiple ankyrin repeat domains 1) Canis lupus familiaris
Analyze
Symbol: SHANK1
Name: SH3 and multiple ankyrin repeat domains 1
RGD ID: 12171490
Description: ENCODES a protein that exhibits ankyrin repeat binding (ortholog); G protein-coupled receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of actin filament bundle assembly (ortholog); positive regulation of dendritic spine development (ortholog); protein-containing complex assembly (ortholog); ASSOCIATED WITH anxiety disorder (ortholog); autistic disorder (ortholog); developmental coordination disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH3 and multiple ankyrin repeat domains protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,086,094 - 106,128,700 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,097,048 - 106,114,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,658,928 - 105,703,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,596,287 - 106,640,573 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,598,771 - 106,640,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,268,735 - 106,312,776 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,910,298 - 105,954,298 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,750,887 - 106,794,971 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SHANK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,086,094 - 106,128,700 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,097,048 - 106,114,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,658,928 - 105,703,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,596,287 - 106,640,573 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,598,771 - 106,640,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,268,735 - 106,312,776 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,910,298 - 105,954,298 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,750,887 - 106,794,971 (+)NCBIUU_Cfam_GSD_1.0
SHANK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,659,255 - 50,719,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,659,255 - 50,719,802 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,162,512 - 51,223,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,856,896 - 55,912,007 (-)NCBINCBI36Build 36hg18NCBI36
Build 341955,856,895 - 55,912,007NCBI
Celera1948,216,374 - 48,271,323 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,499,910 - 47,555,290 (-)NCBIHuRef
CHM1_11951,166,866 - 51,221,938 (-)NCBICHM1_1
T2T-CHM13v2.01953,747,980 - 53,808,613 (-)NCBIT2T-CHM13v2.0
Shank1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,958,343 - 44,009,518 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,959,677 - 44,009,996 (+)EnsemblGRCm39 Ensembl
GRCm38744,308,916 - 44,360,094 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,310,253 - 44,360,572 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,565,634 - 51,613,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,178,306 - 44,225,515 (+)NCBIMGSCv36mm8
Celera739,770,665 - 39,816,636 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
Shank1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,944,416 - 103,993,887 (+)NCBIGRCr8
mRatBN7.2194,807,879 - 94,857,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,808,276 - 94,855,824 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,193,688 - 100,241,225 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,666,330 - 108,713,869 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,956,762 - 102,004,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,297,137 - 100,344,377 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,297,152 - 100,344,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,362,243 - 101,410,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,791,887 - 94,840,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,872,463 - 94,918,294 (+)NCBI
Celera189,071,051 - 89,118,344 (+)NCBICelera
Cytogenetic Map1q22NCBI
Shank1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559523,765 - 564,472 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955559522,466 - 566,275 (+)NCBIChiLan1.0ChiLan1.0
SHANK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,725,929 - 56,787,371 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,647,066 - 58,708,491 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,623,474 - 47,684,476 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,526,557 - 56,580,516 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,526,577 - 56,580,442 (-)Ensemblpanpan1.1panPan2
Shank1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,550,731 - 22,595,302 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889428,417 - 470,060 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889428,404 - 470,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHANK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,451,094 - 55,499,031 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,452,095 - 55,496,304 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,348,953 - 51,395,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHANK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,718,904 - 43,776,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,716,714 - 43,773,945 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,732,704 - 23,793,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shank1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,938,170 - 3,976,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,934,525 - 3,978,607 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SHANK1
447 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 10
Low 1 10 1 5 2 3 2
Below cutoff 4 5 7 5 5 5 1 5 8 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000045850   ⟹   ENSCAFP00000038801
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1106,097,048 - 106,114,673 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028747   ⟹   ENSCAFP00845022627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1106,598,771 - 106,640,573 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028832   ⟹   ENSCAFP00845022687
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1106,598,771 - 106,640,573 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028905   ⟹   ENSCAFP00845022744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1106,598,771 - 106,640,573 (+)Ensembl
RefSeq Acc Id: XM_038467370   ⟹   XP_038323298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11106,268,735 - 106,312,776 (+)NCBI
RefSeq Acc Id: XM_038528065   ⟹   XP_038383993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,750,887 - 106,794,971 (+)NCBI
RefSeq Acc Id: XM_038528066   ⟹   XP_038383994
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,752,935 - 106,794,971 (+)NCBI
RefSeq Acc Id: XM_038528067   ⟹   XP_038383995
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,750,887 - 106,794,914 (+)NCBI
RefSeq Acc Id: XM_038528068   ⟹   XP_038383996
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,750,887 - 106,794,971 (+)NCBI
RefSeq Acc Id: XM_038592365   ⟹   XP_038448293
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01105,910,298 - 105,954,298 (+)NCBI
RefSeq Acc Id: XM_038656157   ⟹   XP_038512085
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01106,596,287 - 106,640,573 (+)NCBI
RefSeq Acc Id: XM_038660965   ⟹   XP_038516893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1105,658,928 - 105,703,011 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000038801   ⟸   ENSCAFT00000045850
RefSeq Acc Id: XP_038323298   ⟸   XM_038467370
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038448293   ⟸   XM_038592365
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512085   ⟸   XM_038656157
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M9N2 (UniProtKB/TrEMBL),   A0A8I3NPZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516893   ⟸   XM_038660965
- Peptide Label: isoform X1
- UniProtKB: A0A8P0PH29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383993   ⟸   XM_038528065
- Peptide Label: isoform X2
- UniProtKB: A0A8P0TPP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383996   ⟸   XM_038528068
- Peptide Label: isoform X3
- UniProtKB: A0A8P0TT45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383995   ⟸   XM_038528067
- Peptide Label: isoform X1
- UniProtKB: A0A8P0PH29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383994   ⟸   XM_038528066
- Peptide Label: isoform X2
- UniProtKB: A0A8P0TPP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022687   ⟸   ENSCAFT00845028832
RefSeq Acc Id: ENSCAFP00845022627   ⟸   ENSCAFT00845028747
RefSeq Acc Id: ENSCAFP00845022744   ⟸   ENSCAFT00845028905
Protein Domains
PDZ   SAM   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002924 Ensembl
  ENSCAFG00000053126 UniProtKB/TrEMBL
  ENSCAFG00030002450 UniProtKB/TrEMBL
  ENSCAFG00040011321 UniProtKB/TrEMBL
  ENSCAFG00845016142 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000096861.1 UniProtKB/TrEMBL
  ENSCAFT00000103072.1 UniProtKB/TrEMBL
  ENSCAFT00000105578.1 UniProtKB/TrEMBL
  ENSCAFT00030004540.1 UniProtKB/TrEMBL
  ENSCAFT00030004555.1 UniProtKB/TrEMBL
  ENSCAFT00030004569.1 UniProtKB/TrEMBL
  ENSCAFT00040020933.1 UniProtKB/TrEMBL
  ENSCAFT00040020998.1 UniProtKB/TrEMBL
  ENSCAFT00040021050.1 UniProtKB/TrEMBL
  ENSCAFT00845028747.1 UniProtKB/TrEMBL
  ENSCAFT00845028832 ENTREZGENE
  ENSCAFT00845028832.1 UniProtKB/TrEMBL
  ENSCAFT00845028905.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene SHANK1 ENTREZGENE
PANTHER SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN UniProtKB/TrEMBL
  SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A8C0M2S4_CANLF UniProtKB/TrEMBL
  A0A8C0M9N2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SAD7_CANLF UniProtKB/TrEMBL
  A0A8I3NPU4_CANLF UniProtKB/TrEMBL
  A0A8I3NPZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NWK6_CANLF UniProtKB/TrEMBL
  A0A8P0PH29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TPP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TT45 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53977 ENTREZGENE