COX7A1 (cytochrome c oxidase subunit 7A1) - Rat Genome Database

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Gene: COX7A1 (cytochrome c oxidase subunit 7A1) Canis lupus familiaris
Analyze
Symbol: COX7A1
Name: cytochrome c oxidase subunit 7A1
RGD ID: 12155717
Description: ENCODES a protein that exhibits oxidoreductase activity (inferred); INVOLVED IN mitochondrial electron transport, cytochrome c to oxygen (inferred); mitochondrial respirasome assembly (inferred); oxidative phosphorylation (inferred); ASSOCIATED WITH Brugada syndrome 5 (ortholog); dilated cardiomyopathy (ortholog); hereditary spastic paraplegia 75 (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial respirasome (inferred); mitochondrial respiratory chain complex IV (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: COX7AH; Cytochrome c oxidase subunit 7A1, mitochondrial; cytochrome c oxidase subunit VIIa polypeptide 1 (muscle); Cytochrome c oxidase subunit VIIa-H; Cytochrome c oxidase subunit VIIa-heart
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,547,179 - 116,548,917 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,547,282 - 116,548,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,953,199 - 115,954,926 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,148,601 - 117,150,329 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,148,693 - 117,150,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,717,978 - 116,719,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,338,225 - 116,339,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,391,271 - 117,392,998 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COX7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,547,179 - 116,548,917 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,547,282 - 116,548,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,953,199 - 115,954,926 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,148,601 - 117,150,329 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,148,693 - 117,150,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,717,978 - 116,719,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,338,225 - 116,339,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,391,271 - 117,392,998 (+)NCBIUU_Cfam_GSD_1.0
COX7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,150,922 - 36,152,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,150,922 - 36,152,449 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,641,824 - 36,643,349 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,333,664 - 41,335,611 (-)NCBINCBI36Build 36hg18NCBI36
Build 341941,333,663 - 41,335,611NCBI
Celera1933,355,996 - 33,357,943 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,147,296 - 33,149,244 (-)NCBIHuRef
CHM1_11936,643,830 - 36,645,777 (-)NCBICHM1_1
T2T-CHM13v2.01938,696,740 - 38,698,266 (-)NCBIT2T-CHM13v2.0
Cox7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,883,596 - 29,885,455 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,883,569 - 29,885,503 (+)EnsemblGRCm39 Ensembl
GRCm38730,184,171 - 30,186,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,184,144 - 30,186,078 (+)EnsemblGRCm38mm10GRCm38
MGSCv37730,969,190 - 30,971,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36729,892,931 - 29,894,790 (+)NCBIMGSCv36mm8
Celera724,780,999 - 24,782,841 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.31NCBI
Cox7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,549,663 - 94,572,330 (+)NCBIGRCr8
mRatBN7.2185,422,162 - 85,447,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,441,871 - 85,445,151 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx190,858,721 - 90,860,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,322,395 - 99,324,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,616,985 - 92,618,658 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0191,070,593 - 91,096,190 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,071,493 - 91,074,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,620,317 - 88,621,868 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,779,961 - 89,783,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera179,797,950 - 79,819,656 (+)NCBICelera
Cytogenetic Map1q21NCBI
LOC102008614
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,442,819 - 2,445,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,442,819 - 2,445,169 (+)NCBIChiLan1.0ChiLan1.0
LOC100973061
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,152,614 - 42,155,935 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,136,168 - 44,137,822 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01933,069,878 - 33,071,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,817,074 - 41,819,025 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,817,074 - 41,819,025 (-)Ensemblpanpan1.1panPan2
LOC101965810
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,392,153 - 11,393,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936922162,286 - 163,839 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936922162,282 - 163,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,517,229 - 45,520,713 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,519,225 - 45,520,721 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,921,420 - 40,922,916 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103234561
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1631,061,789 - 31,063,722 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660738,862,064 - 8,864,153 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101715151
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,392,028 - 10,393,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,392,028 - 10,393,728 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COX7A1
23 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 5 6 1 6 12 8 10 6
Low 1 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005616674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022404444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038468440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038468441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_850347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000010610   ⟹   ENSCAFP00000009836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1116,547,282 - 116,548,917 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000338   ⟹   ENSCAFP00845000239
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1117,148,693 - 117,150,328 (+)Ensembl
RefSeq Acc Id: XM_005616674   ⟹   XP_005616731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11116,547,179 - 116,548,917 (+)NCBI
Dog10K_Boxer_Tasha1115,953,199 - 115,954,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038468440   ⟹   XP_038324368
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11116,717,978 - 116,719,704 (+)NCBI
RefSeq Acc Id: XM_038468441   ⟹   XP_038324369
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11116,717,986 - 116,719,703 (+)NCBI
RefSeq Acc Id: XM_038529214   ⟹   XP_038385142
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01117,391,271 - 117,392,998 (+)NCBI
RefSeq Acc Id: XM_038529215   ⟹   XP_038385143
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01117,391,279 - 117,392,997 (+)NCBI
RefSeq Acc Id: XM_038593477   ⟹   XP_038449405
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01116,338,225 - 116,339,952 (+)NCBI
RefSeq Acc Id: XM_038593478   ⟹   XP_038449406
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01116,338,233 - 116,339,951 (+)NCBI
RefSeq Acc Id: XM_038657320   ⟹   XP_038513248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01117,148,601 - 117,150,329 (+)NCBI
RefSeq Acc Id: XM_038657321   ⟹   XP_038513249
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01117,148,610 - 117,150,328 (+)NCBI
RefSeq Acc Id: XM_850347   ⟹   XP_855440
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11116,547,179 - 116,548,917 (+)NCBI
Dog10K_Boxer_Tasha1115,953,207 - 115,954,925 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005616731   ⟸   XM_005616674
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_855440   ⟸   XM_850347
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L0E9 (UniProtKB/TrEMBL),   A0A8C0T184 (UniProtKB/TrEMBL),   A0A8I3MA85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009836   ⟸   ENSCAFT00000010610
RefSeq Acc Id: XP_038324368   ⟸   XM_038468440
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038324369   ⟸   XM_038468441
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038449405   ⟸   XM_038593477
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038449406   ⟸   XM_038593478
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038513248   ⟸   XM_038657320
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513249   ⟸   XM_038657321
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L0E9 (UniProtKB/TrEMBL),   A0A8C0T184 (UniProtKB/TrEMBL),   A0A8I3MA85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038385142   ⟸   XM_038529214
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038385143   ⟸   XM_038529215
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L0E9 (UniProtKB/TrEMBL),   A0A8C0T184 (UniProtKB/TrEMBL),   A0A8I3MA85 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000239   ⟸   ENSCAFT00845000338


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006578 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009370 UniProtKB/TrEMBL
  ENSCAFG00040018666 UniProtKB/TrEMBL
  ENSCAFG00845000219 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010610.5 UniProtKB/TrEMBL
  ENSCAFT00030017336.1 UniProtKB/TrEMBL
  ENSCAFT00040034543.1 UniProtKB/TrEMBL
  ENSCAFT00845000338 ENTREZGENE
  ENSCAFT00845000338.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.91.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro COX7a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su7a_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytc_oxidase_su7a_met UniProtKB/TrEMBL
NCBI Gene COX7A1 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR10510 UniProtKB/TrEMBL
Pfam COX7a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0L0E9 ENTREZGENE
  A0A8C0T184 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MA85 ENTREZGENE, UniProtKB/TrEMBL
  CX7A1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:53694 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-27 COX7A1  cytochrome c oxidase subunit 7A1    cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)  Symbol and/or name change 5135510 APPROVED