CMA1 (chymase 1) - Rat Genome Database

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Gene: CMA1 (chymase 1) Canis lupus familiaris
Analyze
Symbol: CMA1
Name: chymase 1
RGD ID: 12155305
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); peptide binding (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); midbrain development (ortholog); peptide metabolic process (ortholog); PARTICIPATES IN angiotensin II signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH Anaphylaxis (ortholog); asthma (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular region (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-chymase; chymase; chymase 1, mast cell; mast cell chymase; mast cell protease I; serine protease
RGD Orthologs
Human
Mouse
Rat
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,438,244 - 4,441,189 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,438,244 - 4,441,189 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,359,948 - 4,362,893 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,549,708 - 4,552,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,549,715 - 4,552,661 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,239,198 - 4,242,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,301,888 - 4,304,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,564,103 - 4,567,048 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2378872   PMID:3122835   PMID:9379034   PMID:15744002   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,438,244 - 4,441,189 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,438,244 - 4,441,189 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,359,948 - 4,362,893 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,549,708 - 4,552,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,549,715 - 4,552,661 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,239,198 - 4,242,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,301,888 - 4,304,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,564,103 - 4,567,048 (-)NCBIUU_Cfam_GSD_1.0
CMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,505,353 - 24,508,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,505,353 - 24,508,265 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,974,559 - 24,977,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,044,552 - 24,047,311 (-)NCBINCBI36Build 36hg18NCBI36
Build 341424,044,551 - 24,047,311NCBI
Celera144,839,478 - 4,842,237 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef145,089,481 - 5,092,240 (-)NCBIHuRef
CHM1_11424,973,574 - 24,976,333 (-)NCBICHM1_1
T2T-CHM13v2.01418,704,211 - 18,707,123 (-)NCBIT2T-CHM13v2.0
Cma1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,178,908 - 56,182,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,178,908 - 56,182,132 (-)EnsemblGRCm39 Ensembl
GRCm381455,941,451 - 55,944,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,941,451 - 55,944,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,560,288 - 56,563,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,895,522 - 54,898,732 (-)NCBIMGSCv36mm8
Celera1453,745,166 - 53,748,376 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Cma1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,387,351 - 33,390,133 (-)NCBIGRCr8
mRatBN7.21529,417,451 - 29,420,233 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,417,451 - 29,420,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,263,077 - 31,265,859 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,410,295 - 32,413,077 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,652,671 - 30,655,453 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,601,037 - 34,603,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,601,037 - 34,603,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,490,971 - 38,493,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,083,202 - 34,084,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11534,098,901 - 34,102,176 (-)NCBI
Celera1528,991,244 - 28,994,014 (-)NCBICelera
RH 3.4 Map15213.78RGD
Cytogenetic Map15p12NCBI
CMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,855,859 - 25,858,985 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11425,072,378 - 25,075,477 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,277,269 - 5,280,335 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,400,677 - 23,402,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,400,345 - 23,403,548 (-)Ensemblpanpan1.1panPan2
CMA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,471,767 - 1,475,062 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,471,725 - 1,474,692 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,158,008 - 13,161,323 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cma1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,021,959 - 8,024,851 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,021,965 - 8,024,763 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CMA1
22 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1 1 2 1 6 4 2
Low 4 1 18 5 4 5 2 6 6 4
Below cutoff 4 3 4 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019746   ⟹   ENSCAFP00000018316
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,438,244 - 4,441,189 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014479   ⟹   ENSCAFP00845011218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,549,715 - 4,552,661 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014505   ⟹   ENSCAFP00845011240
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,549,876 - 4,552,661 (-)Ensembl
RefSeq Acc Id: NM_001013424   ⟹   NP_001013442
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,438,244 - 4,441,189 (-)NCBI
Dog10K_Boxer_Tasha84,359,948 - 4,362,893 (-)NCBI
ROS_Cfam_1.084,549,715 - 4,552,661 (-)NCBI
UMICH_Zoey_3.184,239,198 - 4,242,142 (-)NCBI
UNSW_CanFamBas_1.084,301,888 - 4,304,834 (-)NCBI
UU_Cfam_GSD_1.084,564,103 - 4,567,048 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038672895   ⟹   XP_038528823
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,549,708 - 4,552,647 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013442   ⟸   NM_001013424
- Peptide Label: precursor
- UniProtKB: P21842 (UniProtKB/Swiss-Prot),   A0A8C0LK70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000018316   ⟸   ENSCAFT00000019746
RefSeq Acc Id: XP_038528823   ⟸   XM_038672895
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845011218   ⟸   ENSCAFT00845014479
RefSeq Acc Id: ENSCAFP00845011240   ⟸   ENSCAFT00845014505
Protein Domains
Peptidase S1

Promoters
RGD ID:13684156
Promoter ID:EPDNEW_C2225
Type:single initiation site
Name:CMA1_1
Description:chymase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,441,189 - 4,441,249EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012443 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030012378 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040008127 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805023596 UniProtKB/Swiss-Prot
  ENSCAFG00845008224 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019746.5 UniProtKB/Swiss-Prot
  ENSCAFT00000102055.1 UniProtKB/TrEMBL
  ENSCAFT00030022936.1 UniProtKB/Swiss-Prot
  ENSCAFT00030022945.1 UniProtKB/TrEMBL
  ENSCAFT00040015211.1 UniProtKB/Swiss-Prot
  ENSCAFT00040015251.1 UniProtKB/TrEMBL
  ENSCAFT00805042700 UniProtKB/Swiss-Prot
  ENSCAFT00845014479 ENTREZGENE
  ENSCAFT00845014479.1 UniProtKB/Swiss-Prot
  ENSCAFT00845014505.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report cfa:490628 UniProtKB/Swiss-Prot
NCBI Gene CMA1 ENTREZGENE
PANTHER CHYMASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0LK70 ENTREZGENE
  A0A8C0NB05_CANLF UniProtKB/TrEMBL
  A0A8I3NAG8_CANLF UniProtKB/TrEMBL
  CMA1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:49768 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 CMA1  chymase 1    chymase 1, mast cell  Symbol and/or name change 5135510 APPROVED