STAC3 (SH3 and cysteine rich domain 3) - Rat Genome Database

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Gene: STAC3 (SH3 and cysteine rich domain 3) Canis lupus familiaris
Analyze
Symbol: STAC3
Name: SH3 and cysteine rich domain 3
RGD ID: 12143326
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN neuromuscular synaptic transmission (ortholog); positive regulation of protein localization to plasma membrane (ortholog); skeletal muscle contraction (ortholog); ASSOCIATED WITH congenital myopathy (ortholog); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH3 and cysteine-rich domain-containing protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,370,340 - 1,377,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,434,018 - 1,441,443 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,380,726 - 1,388,155 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1101,357,308 - 1,364,738 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,599,294 - 1,606,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,724,219 - 1,731,673 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
STAC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,370,340 - 1,377,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,434,018 - 1,441,443 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,380,726 - 1,388,155 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1101,357,308 - 1,364,738 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,599,294 - 1,606,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,724,219 - 1,731,673 (-)NCBIUU_Cfam_GSD_1.0
STAC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,243,458 - 57,251,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,243,453 - 57,251,188 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,637,241 - 57,644,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,923,509 - 55,931,236 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,923,508 - 55,931,236NCBI
Celera1257,291,469 - 57,299,250 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,676,118 - 54,683,830 (-)NCBIHuRef
CHM1_11257,605,339 - 57,613,080 (-)NCBICHM1_1
T2T-CHM13v2.01257,211,695 - 57,219,414 (-)NCBIT2T-CHM13v2.0
Stac3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,337,505 - 127,344,692 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,337,555 - 127,344,692 (+)EnsemblGRCm39 Ensembl
GRCm3810127,501,617 - 127,508,823 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,501,686 - 127,508,823 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,938,773 - 126,945,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,904,666 - 126,911,764 (+)NCBIMGSCv36mm8
Celera10129,893,229 - 129,900,583 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Stac3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,227,151 - 65,235,884 (+)NCBIGRCr8
mRatBN7.2763,343,078 - 63,350,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,343,186 - 63,350,589 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,232,464 - 65,239,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,434,891 - 67,442,294 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,236,106 - 67,243,510 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,807,427 - 70,815,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,807,867 - 70,815,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,981,174 - 70,988,656 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,478,506 - 67,485,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,500,312 - 67,506,640 (+)NCBI
Celera760,482,101 - 60,489,521 (+)NCBICelera
Cytogenetic Map7q22NCBI
Stac3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,971,450 - 4,980,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,971,450 - 4,980,262 (-)NCBIChiLan1.0ChiLan1.0
STAC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,087,303 - 37,100,817 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,083,577 - 37,094,995 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,674,537 - 31,683,917 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,928,955 - 31,936,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,928,955 - 31,936,251 (+)Ensemblpanpan1.1panPan2
Stac3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,424,374 - 57,433,731 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,436,425 - 1,443,595 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,436,505 - 1,444,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,549,010 - 22,719,054 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,549,008 - 22,556,330 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,376,741 - 24,390,343 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,149,572 - 53,163,036 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,154,755 - 53,163,090 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,809,786 - 192,817,153 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stac3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,695,870 - 10,704,334 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,694,539 - 10,704,320 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in STAC3
37 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014117182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038633416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_014117182   ⟹   XP_013972657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,370,340 - 1,374,537 (-)NCBI
Dog10K_Boxer_Tasha101,434,018 - 1,438,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038487870   ⟹   XP_038343798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,357,308 - 1,364,738 (-)NCBI
RefSeq Acc Id: XM_038487871   ⟹   XP_038343799
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,357,308 - 1,364,706 (-)NCBI
RefSeq Acc Id: XM_038487872   ⟹   XP_038343800
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,357,308 - 1,361,506 (-)NCBI
RefSeq Acc Id: XM_038549765   ⟹   XP_038405693
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0101,724,219 - 1,731,673 (-)NCBI
RefSeq Acc Id: XM_038549766   ⟹   XP_038405694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0101,724,219 - 1,731,641 (-)NCBI
RefSeq Acc Id: XM_038549767   ⟹   XP_038405695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0101,724,219 - 1,728,442 (-)NCBI
RefSeq Acc Id: XM_038613724   ⟹   XP_038469652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,599,294 - 1,606,729 (-)NCBI
RefSeq Acc Id: XM_038613725   ⟹   XP_038469653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,599,294 - 1,606,697 (-)NCBI
RefSeq Acc Id: XM_038613726   ⟹   XP_038469654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,599,294 - 1,603,495 (-)NCBI
RefSeq Acc Id: XM_038633416   ⟹   XP_038489344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha101,434,018 - 1,441,411 (-)NCBI
RefSeq Acc Id: XM_038679086   ⟹   XP_038535014
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,380,726 - 1,388,155 (-)NCBI
RefSeq Acc Id: XM_038679087   ⟹   XP_038535015
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,380,726 - 1,388,123 (-)NCBI
RefSeq Acc Id: XM_038679088   ⟹   XP_038535016
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,380,726 - 1,384,925 (-)NCBI
RefSeq Acc Id: XM_538246   ⟹   XP_538246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,370,340 - 1,377,769 (-)NCBI
Dog10K_Boxer_Tasha101,434,018 - 1,441,443 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_538246   ⟸   XM_538246
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SDL4 (UniProtKB/TrEMBL),   A0A8P0PN63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013972657   ⟸   XM_014117182
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_038343798   ⟸   XM_038487870
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038343799   ⟸   XM_038487871
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038343800   ⟸   XM_038487872
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038469652   ⟸   XM_038613724
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469653   ⟸   XM_038613725
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469654   ⟸   XM_038613726
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038535014   ⟸   XM_038679086
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SDL4 (UniProtKB/TrEMBL),   A0A8P0PN63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038535015   ⟸   XM_038679087
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SDL4 (UniProtKB/TrEMBL),   A0A8P0PN63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038535016   ⟸   XM_038679088
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038489344   ⟸   XM_038633416
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SDL4 (UniProtKB/TrEMBL),   A0A8P0PN63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405693   ⟸   XM_038549765
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SDL4 (UniProtKB/TrEMBL),   A0A8P0PN63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405694   ⟸   XM_038549766
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SDL4 (UniProtKB/TrEMBL),   A0A8P0PN63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405695   ⟸   XM_038549767
- Peptide Label: isoform X2
Protein Domains
Phorbol-ester/DAG-type   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000215 UniProtKB/TrEMBL
  ENSCAFG00040011807 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000107385.1 UniProtKB/TrEMBL
  ENSCAFT00040022958.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  STAC1/2/3 UniProtKB/TrEMBL
  Stac3_SH3_1 UniProtKB/TrEMBL
NCBI Gene STAC3 ENTREZGENE
PANTHER PTHR15135 UniProtKB/TrEMBL
  SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
  STAC2_u1 UniProtKB/TrEMBL
PRINTS P67PHOX UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8C0SDL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PN63 ENTREZGENE
UniProt Secondary A0A8P0PN63 UniProtKB/TrEMBL
VGNC ID VGNC:46872 ENTREZGENE