BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) Canis lupus familiaris
Analyze
Symbol: BUB1B
Name: BUB1 mitotic checkpoint serine/threonine kinase B
RGD ID: 12137188
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); INVOLVED IN metaphase/anaphase transition of mitotic cell cycle (ortholog); protein localization to chromosome, centromeric region (ortholog); ASSOCIATED WITH Aneuploidy (ortholog); Bloom syndrome (ortholog); cerebral palsy (ortholog); FOUND IN mitotic checkpoint complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BUB1 budding uninhibited by benzimidazoles 1 homolog beta; budding uninhibited by benzimidazoles 1 homolog beta; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,361,982 - 7,410,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,322,912 - 7,438,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,416,730 - 7,464,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,490,487 - 7,538,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,490,458 - 7,538,459 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,412,929 - 7,461,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,519,268 - 7,567,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,647,445 - 7,695,793 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
BUB1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,361,982 - 7,410,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,322,912 - 7,438,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,416,730 - 7,464,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,490,487 - 7,538,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,490,458 - 7,538,459 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,412,929 - 7,461,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,519,268 - 7,567,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,647,445 - 7,695,793 (+)NCBIUU_Cfam_GSD_1.0
BUB1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,161,069 - 40,221,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,161,023 - 40,221,123 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,453,270 - 40,513,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,240,530 - 38,300,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,240,529 - 38,300,627NCBI
Celera1517,219,190 - 17,279,313 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,296,260 - 17,356,314 (+)NCBIHuRef
CHM1_11540,573,169 - 40,633,290 (+)NCBICHM1_1
T2T-CHM13v2.01537,967,956 - 38,028,008 (+)NCBIT2T-CHM13v2.0
Bub1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,428,684 - 118,472,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,428,692 - 118,472,072 (+)EnsemblGRCm39 Ensembl
GRCm382118,598,202 - 118,641,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,598,211 - 118,641,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,423,947 - 118,467,328 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,289,697 - 118,333,032 (+)NCBIMGSCv36mm8
Celera2119,745,153 - 119,796,040 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.4NCBI
Bub1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,017,019 - 126,069,470 (+)NCBIGRCr8
mRatBN7.23105,563,089 - 105,615,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,563,138 - 105,615,547 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,236,836 - 109,289,246 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,832,398 - 117,884,807 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,492,765 - 115,545,173 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,367,949 - 110,420,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,367,939 - 110,420,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,912,599 - 116,965,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,063,018 - 105,116,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,974,011 - 104,978,578 (+)NCBI
Celera3104,480,144 - 104,532,190 (+)NCBICelera
Cytogenetic Map3q35NCBI
Bub1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,105,261 - 7,160,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,105,302 - 7,159,121 (+)NCBIChiLan1.0ChiLan1.0
BUB1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,395,286 - 29,455,478 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,546,708 - 33,606,921 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,095,383 - 19,155,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,350,826 - 37,410,661 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,350,826 - 37,410,648 (+)Ensemblpanpan1.1panPan2
Bub1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,783,495 - 85,851,191 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,633,536 - 3,695,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,631,760 - 3,696,024 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BUB1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,092,958 - 131,143,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,093,026 - 131,143,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,217,357 - 146,249,488 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BUB1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,769,955 - 42,855,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,792,830 - 42,855,306 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,101,756 - 98,168,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bub1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,492,799 - 7,533,408 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,477,046 - 7,533,322 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BUB1B
454 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 5 5 13 6 6 12 10 1
Below cutoff 9 6 6 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014186   ⟹   ENSCAFP00000013122
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl307,322,912 - 7,410,159 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063488   ⟹   ENSCAFP00000050841
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl307,322,912 - 7,438,052 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048179   ⟹   ENSCAFP00845037791
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl307,490,458 - 7,538,459 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048303   ⟹   ENSCAFP00845037890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl307,490,458 - 7,538,459 (+)Ensembl
RefSeq Acc Id: XM_005638239   ⟹   XP_005638296
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1307,361,982 - 7,410,162 (+)NCBI
Dog10K_Boxer_Tasha307,416,730 - 7,464,873 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038441954   ⟹   XP_038297882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0307,490,487 - 7,538,685 (+)NCBI
RefSeq Acc Id: XM_038441955   ⟹   XP_038297883
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0307,490,487 - 7,538,685 (+)NCBI
RefSeq Acc Id: XM_038516441   ⟹   XP_038372369
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1307,412,929 - 7,461,263 (+)NCBI
RefSeq Acc Id: XM_038516442   ⟹   XP_038372370
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1307,412,929 - 7,461,263 (+)NCBI
RefSeq Acc Id: XM_038580030   ⟹   XP_038435958
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0307,647,445 - 7,695,793 (+)NCBI
RefSeq Acc Id: XM_038580031   ⟹   XP_038435959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0307,647,445 - 7,695,793 (+)NCBI
RefSeq Acc Id: XM_038644304   ⟹   XP_038500232
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0307,519,268 - 7,567,181 (+)NCBI
RefSeq Acc Id: XM_038644305   ⟹   XP_038500233
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0307,519,268 - 7,567,181 (+)NCBI
RefSeq Acc Id: XM_845350   ⟹   XP_850443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1307,361,982 - 7,410,162 (+)NCBI
Dog10K_Boxer_Tasha307,416,730 - 7,464,873 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_850443   ⟸   XM_845350
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SDX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005638296   ⟸   XM_005638239
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PXH1 (UniProtKB/TrEMBL),   A0A8P0SDX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000050841   ⟸   ENSCAFT00000063488
RefSeq Acc Id: ENSCAFP00000013122   ⟸   ENSCAFT00000014186
RefSeq Acc Id: XP_038372369   ⟸   XM_038516441
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038372370   ⟸   XM_038516442
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038500232   ⟸   XM_038644304
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038500233   ⟸   XM_038644305
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038297882   ⟸   XM_038441954
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PXH1 (UniProtKB/TrEMBL),   A0A8P0SDX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038297883   ⟸   XM_038441955
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SDX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435958   ⟸   XM_038580030
- Peptide Label: isoform X5
- UniProtKB: A0A8I3PXH1 (UniProtKB/TrEMBL),   A0A8P0SDX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435959   ⟸   XM_038580031
- Peptide Label: isoform X6
- UniProtKB: A0A8P0SDX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845037791   ⟸   ENSCAFT00845048179
RefSeq Acc Id: ENSCAFP00845037890   ⟸   ENSCAFT00845048303
Protein Domains
BUB1 N-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008877 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024551 UniProtKB/TrEMBL
  ENSCAFG00040025404 UniProtKB/TrEMBL
  ENSCAFG00845027328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014186.5 UniProtKB/TrEMBL
  ENSCAFT00000063488.2 UniProtKB/TrEMBL
  ENSCAFT00030045170.1 UniProtKB/TrEMBL
  ENSCAFT00030045215.1 UniProtKB/TrEMBL
  ENSCAFT00040047413.1 UniProtKB/TrEMBL
  ENSCAFT00845048179 ENTREZGENE
  ENSCAFT00845048179.1 UniProtKB/TrEMBL
  ENSCAFT00845048303.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.430 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Bub1/Mad3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Mad3/Bub1_I UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
KEGG Report cfa:608350 UniProtKB/TrEMBL
NCBI Gene BUB1B ENTREZGENE
PANTHER MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BETA UniProtKB/TrEMBL
  PTHR14030 UniProtKB/TrEMBL
Pfam Mad3_BUB1_I UniProtKB/TrEMBL
PROSITE BUB1_N UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART Mad3_BUB1_I UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0PGL0_CANLF UniProtKB/TrEMBL
  A0A8C0TS97_CANLF UniProtKB/TrEMBL
  A0A8I3PXH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PXT4_CANLF UniProtKB/TrEMBL
  A0A8P0P0N7_CANLF UniProtKB/TrEMBL
  A0A8P0SDX3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38566 ENTREZGENE