AFM (afamin) - Rat Genome Database

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Gene: AFM (afamin) Canis lupus familiaris
Analyze
Symbol: AFM
Name: afamin
RGD ID: 12115977
Description: ENCODES a protein that exhibits lipid binding (inferred); metal ion binding (inferred); vitamin E binding (inferred); INVOLVED IN protein stabilization (inferred); protein transport within extracellular region (inferred); vitamin transport (inferred); ASSOCIATED WITH acute kidney failure (ortholog); Drug-Related Side Effects and Adverse Reactions (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,212,230 - 62,235,136 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,053,814 - 62,294,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,881,887 - 61,904,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,021,767 - 63,044,655 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,021,855 - 63,044,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,633,366 - 62,656,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,126,432 - 62,149,372 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,262,556 - 63,285,453 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AFM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,212,230 - 62,235,136 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,053,814 - 62,294,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,881,887 - 61,904,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,021,767 - 63,044,655 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,021,855 - 63,044,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,633,366 - 62,656,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,126,432 - 62,149,372 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,262,556 - 63,285,453 (+)NCBIUU_Cfam_GSD_1.0
AFM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,481,745 - 73,504,001 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,481,745 - 73,504,001 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,347,462 - 74,369,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,566,326 - 74,588,582 (+)NCBINCBI36Build 36hg18NCBI36
Build 34474,712,496 - 74,734,753NCBI
Celera471,707,194 - 71,729,436 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,158,855 - 70,181,099 (+)NCBIHuRef
CHM1_1474,383,462 - 74,405,708 (+)NCBICHM1_1
T2T-CHM13v2.0476,825,372 - 76,847,610 (+)NCBIT2T-CHM13v2.0
Afm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,666,808 - 90,701,403 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,666,791 - 90,701,402 (+)EnsemblGRCm39 Ensembl
GRCm38590,518,949 - 90,553,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,518,932 - 90,553,543 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,947,975 - 90,982,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,594,163 - 91,641,425 (+)NCBIMGSCv36mm8
Celera588,680,306 - 88,704,975 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Afm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,815,194 - 17,848,042 (-)NCBIGRCr8
mRatBN7.21417,531,022 - 17,563,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,531,024 - 17,563,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,525,337 - 17,550,140 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,844,268 - 18,869,067 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,536,413 - 17,568,193 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,078,678 - 19,132,212 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,078,680 - 19,132,208 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,035,336 - 19,039,510 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01418,988,809 - 19,008,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,049,664 - 19,082,977 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11419,049,663 - 19,082,977 (-)NCBI
Celera1416,899,392 - 16,930,240 (-)NCBICelera
Cytogenetic Map14p22NCBI
AFM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,559,516 - 56,583,201 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,748,574 - 56,771,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,691,556 - 50,714,140 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,523,712 - 56,545,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,519,389 - 56,545,974 (-)Ensemblpanpan1.1panPan2
AFM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,706,896 - 69,728,255 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,706,823 - 69,728,269 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2873,806,942 - 73,828,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1721,950,222 - 21,972,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl721,950,705 - 21,972,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084824,453 - 846,386 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473533,945,107 - 34,015,900 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AFM
382 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845010622   ⟹   ENSCAFP00845008275
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1363,021,855 - 63,044,642 (+)Ensembl
RefSeq Acc Id: XM_038494019   ⟹   XP_038349947
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11362,633,366 - 62,656,263 (+)NCBI
RefSeq Acc Id: XM_038556310   ⟹   XP_038412238
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,262,556 - 63,285,453 (+)NCBI
RefSeq Acc Id: XM_038620250   ⟹   XP_038476178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,126,432 - 62,149,372 (+)NCBI
RefSeq Acc Id: XM_038685877   ⟹   XP_038541805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,021,767 - 63,044,655 (+)NCBI
RefSeq Acc Id: XM_532408   ⟹   XP_532408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,212,230 - 62,235,136 (+)NCBI
Dog10K_Boxer_Tasha1361,881,887 - 61,904,769 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_532408   ⟸   XM_532408
- UniProtKB: A0A8I3NCZ8 (UniProtKB/TrEMBL),   A0A8P0N5Z8 (UniProtKB/TrEMBL),   A0A8C0LXA8 (UniProtKB/TrEMBL),   A0A8C0NVT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038349947   ⟸   XM_038494019
RefSeq Acc Id: XP_038476178   ⟸   XM_038620250
RefSeq Acc Id: XP_038541805   ⟸   XM_038685877
- UniProtKB: A0A8I3NCZ8 (UniProtKB/TrEMBL),   A0A8P0N5Z8 (UniProtKB/TrEMBL),   A0A8C0LXA8 (UniProtKB/TrEMBL),   A0A8C0NVT8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412238   ⟸   XM_038556310
- UniProtKB: A0A8C0LXA8 (UniProtKB/TrEMBL),   A0A8C0NVT8 (UniProtKB/TrEMBL),   A0A8I3NCZ8 (UniProtKB/TrEMBL),   A0A8P0N5Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845008275   ⟸   ENSCAFT00845010622
Protein Domains
Albumin

Promoters
RGD ID:13685685
Promoter ID:EPDNEW_C3752
Type:multiple initiation site
Name:AFM_1
Description:afamin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,212,324 - 62,212,384EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003020 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00000059309 UniProtKB/TrEMBL
  ENSCAFG00030019553 UniProtKB/TrEMBL
  ENSCAFG00030019954 UniProtKB/TrEMBL
  ENSCAFG00040007154 UniProtKB/TrEMBL
  ENSCAFG00040007523 UniProtKB/TrEMBL
  ENSCAFG00845005998 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004843.5 UniProtKB/TrEMBL
  ENSCAFT00000004851.4 UniProtKB/TrEMBL
  ENSCAFT00000036330.5 UniProtKB/TrEMBL
  ENSCAFT00000080490.2 UniProtKB/TrEMBL
  ENSCAFT00000107297.1 UniProtKB/TrEMBL
  ENSCAFT00000108325.1 UniProtKB/TrEMBL
  ENSCAFT00030035893.1 UniProtKB/TrEMBL
  ENSCAFT00030036239.1 UniProtKB/TrEMBL
  ENSCAFT00030036280.1 UniProtKB/TrEMBL
  ENSCAFT00030036680.1 UniProtKB/TrEMBL
  ENSCAFT00030036724.1 UniProtKB/TrEMBL
  ENSCAFT00040013450.1 UniProtKB/TrEMBL
  ENSCAFT00040013468.1 UniProtKB/TrEMBL
  ENSCAFT00040013557.1 UniProtKB/TrEMBL
  ENSCAFT00040014003.1 UniProtKB/TrEMBL
  ENSCAFT00845010622 ENTREZGENE
  ENSCAFT00845010622.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.246.10 UniProtKB/TrEMBL
InterPro ALB/AFP/VDB UniProtKB/TrEMBL
  Serum_albumin-like UniProtKB/TrEMBL
  Serum_albumin/AFP/Afamin UniProtKB/TrEMBL
  Serum_albumin_CS UniProtKB/TrEMBL
  Serum_albumin_N UniProtKB/TrEMBL
NCBI Gene AFM ENTREZGENE
PANTHER AFAMIN UniProtKB/TrEMBL
  ALBUMIN UniProtKB/TrEMBL
  PTHR11385 UniProtKB/TrEMBL
Pfam Serum_albumin UniProtKB/TrEMBL
PIRSF Serum_albumin_subgroup UniProtKB/TrEMBL
PRINTS AFETOPROTEIN UniProtKB/TrEMBL
  SERUMALBUMIN UniProtKB/TrEMBL
PROSITE ALBUMIN_1 UniProtKB/TrEMBL
  ALBUMIN_2 UniProtKB/TrEMBL
SMART ALBUMIN UniProtKB/TrEMBL
Superfamily-SCOP SSF48552 UniProtKB/TrEMBL
UniProt A0A8C0LXA8 ENTREZGENE
  A0A8C0NSI4_CANLF UniProtKB/TrEMBL
  A0A8C0NVT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NWI3_CANLF UniProtKB/TrEMBL
  A0A8C0P084_CANLF UniProtKB/TrEMBL
  A0A8C0QN02_CANLF UniProtKB/TrEMBL
  A0A8C0RZQ0_CANLF UniProtKB/TrEMBL
  A0A8C0S064_CANLF UniProtKB/TrEMBL
  A0A8I3NCZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N5Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N604_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0P664 UniProtKB/TrEMBL
  A0A8P0TKM1 UniProtKB/TrEMBL
VGNC ID VGNC:37691 ENTREZGENE