NDUFAF2 (NADH:ubiquinone oxidoreductase complex assembly factor 2) - Rat Genome Database

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Gene: NDUFAF2 (NADH:ubiquinone oxidoreductase complex assembly factor 2) Canis lupus familiaris
Analyze
Symbol: NDUFAF2
Name: NADH:ubiquinone oxidoreductase complex assembly factor 2
RGD ID: 12113173
Description: ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN mitochondrial respiratory chain complex I assembly (ortholog); negative regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Cockayne syndrome (ortholog); Cockayne syndrome A (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mimitin, mitochondrial; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NDUFA12L
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1247,559,002 - 47,706,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl247,559,111 - 47,706,696 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha244,634,826 - 44,782,500 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0248,036,173 - 48,183,935 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl248,036,215 - 48,184,975 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1245,106,313 - 45,253,984 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,892,845 - 46,040,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0246,744,840 - 46,892,527 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
NDUFAF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1247,559,002 - 47,706,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl247,559,111 - 47,706,696 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha244,634,826 - 44,782,500 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0248,036,173 - 48,183,935 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl248,036,215 - 48,184,975 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1245,106,313 - 45,253,984 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,892,845 - 46,040,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0246,744,840 - 46,892,527 (+)NCBIUU_Cfam_GSD_1.0
NDUFAF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38560,945,205 - 61,153,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl560,945,177 - 61,154,531 (+)EnsemblGRCh38hg38GRCh38
GRCh37560,241,032 - 60,448,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36560,276,798 - 60,484,609 (+)NCBINCBI36Build 36hg18NCBI36
Celera557,182,020 - 57,389,876 (+)NCBICelera
Cytogenetic Map5q12.1NCBI
HuRef557,199,067 - 57,407,550 (+)NCBIHuRef
CHM1_1560,240,638 - 60,448,527 (+)NCBICHM1_1
T2T-CHM13v2.0561,761,596 - 61,969,442 (+)NCBIT2T-CHM13v2.0
Ndufaf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913108,189,123 - 108,295,189 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13108,139,249 - 108,295,157 (-)EnsemblGRCm39 Ensembl
GRCm3813108,052,589 - 108,158,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13108,002,715 - 108,158,623 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713108,842,783 - 108,948,819 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613109,173,336 - 109,279,372 (-)NCBIMGSCv36mm8
Celera13112,390,296 - 112,496,090 (-)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1359.63NCBI
Ndufaf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8241,269,141 - 41,380,895 (-)NCBIGRCr8
mRatBN7.2239,535,680 - 39,647,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl239,535,689 - 39,647,316 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx246,641,151 - 46,752,431 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0244,699,829 - 44,811,109 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0239,550,564 - 39,661,060 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0239,322,145 - 39,434,535 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl239,321,741 - 39,434,560 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0258,406,989 - 58,518,870 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4239,269,415 - 39,382,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera235,377,806 - 35,489,078 (-)NCBICelera
Cytogenetic Map2q14NCBI
Ndufaf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554467,345,467 - 7,439,885 (-)NCBIChiLan1.0ChiLan1.0
NDUFAF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2452,754,496 - 52,964,092 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1550,908,131 - 51,117,728 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0552,843,931 - 53,053,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1554,484,800 - 54,693,930 (-)NCBIpanpan1.1PanPan1.1panPan2
Ndufaf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213198,388,042 - 198,623,479 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364807,382,187 - 7,559,981 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364807,385,986 - 7,559,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFAF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1639,770,466 - 39,950,785 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11639,770,398 - 39,950,786 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21642,832,726 - 42,874,950 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFAF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1457,128,382 - 57,326,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl457,128,385 - 57,326,966 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660495,617,664 - 5,817,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufaf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248158,863,827 - 9,054,453 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248158,862,725 - 9,054,539 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NDUFAF2
950 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 2 1 6 8 1
Low 4 3 21 6 6 6 6 6 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011474   ⟹   ENSCAFP00000010631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl247,559,111 - 47,706,696 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845013632   ⟹   ENSCAFP00845010585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl248,036,215 - 48,184,975 (+)Ensembl
RefSeq Acc Id: XM_038469880   ⟹   XP_038325808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1245,106,313 - 45,253,984 (+)NCBI
RefSeq Acc Id: XM_038530687   ⟹   XP_038386615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0246,744,840 - 46,892,527 (+)NCBI
RefSeq Acc Id: XM_038594908   ⟹   XP_038450836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0245,892,845 - 46,040,518 (+)NCBI
RefSeq Acc Id: XM_038658985   ⟹   XP_038514913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0248,036,173 - 48,183,935 (+)NCBI
RefSeq Acc Id: XM_535246   ⟹   XP_535246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1247,559,002 - 47,706,704 (+)NCBI
Dog10K_Boxer_Tasha244,634,826 - 44,782,500 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_535246   ⟸   XM_535246
- UniProtKB: A0A8C0LW13 (UniProtKB/TrEMBL),   A0A8C0R6S0 (UniProtKB/TrEMBL),   A0A8I3N1H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010631   ⟸   ENSCAFT00000011474
RefSeq Acc Id: XP_038325808   ⟸   XM_038469880
RefSeq Acc Id: XP_038450836   ⟸   XM_038594908
RefSeq Acc Id: XP_038514913   ⟸   XM_038658985
- UniProtKB: A0A8C0LW13 (UniProtKB/TrEMBL),   A0A8C0R6S0 (UniProtKB/TrEMBL),   A0A8I3N1H0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386615   ⟸   XM_038530687
- UniProtKB: A0A8C0LW13 (UniProtKB/TrEMBL),   A0A8C0R6S0 (UniProtKB/TrEMBL),   A0A8I3N1H0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010585   ⟸   ENSCAFT00845013632

Promoters
RGD ID:13682477
Promoter ID:EPDNEW_C545
Type:initiation region
Name:NDUFAF2_1
Description:NADH:ubiquinone oxidoreductase complex assembly factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1247,559,082 - 47,559,142EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007163 Ensembl
  ENSCAFG00000058414 UniProtKB/TrEMBL
  ENSCAFG00030001615 UniProtKB/TrEMBL
  ENSCAFG00040002265 UniProtKB/TrEMBL
  ENSCAFG00845007756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000095032.1 UniProtKB/TrEMBL
  ENSCAFT00030002890.1 UniProtKB/TrEMBL
  ENSCAFT00040004303.1 UniProtKB/TrEMBL
  ENSCAFT00845013632 ENTREZGENE
  ENSCAFT00845013632.1 UniProtKB/TrEMBL
InterPro NDUFA12 UniProtKB/TrEMBL
KEGG Report cfa:478067 UniProtKB/TrEMBL
NCBI Gene NDUFAF2 ENTREZGENE
PANTHER ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2 UniProtKB/TrEMBL
  NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2 UniProtKB/TrEMBL
Pfam NDUFA12 UniProtKB/TrEMBL
UniProt A0A8C0LW13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R6S0 ENTREZGENE
  A0A8I3N1H0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43692 ENTREZGENE