WDR73 (WD repeat domain 73) - Rat Genome Database

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Gene: WDR73 (WD repeat domain 73) Canis lupus familiaris
Analyze
Symbol: WDR73
Name: WD repeat domain 73
RGD ID: 12078562
Description: INVOLVED IN cytoplasmic microtubule organization (inferred); negative regulation of apoptotic process (inferred); nucleus organization (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); dystonia (ortholog); FOUND IN cleavage furrow (inferred); cytosol (inferred); spindle pole (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WD repeat-containing protein 73
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,914,048 - 53,927,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,914,619 - 53,927,034 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha356,554,244 - 56,566,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0354,334,301 - 54,347,044 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,333,081 - 54,347,015 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,853,220 - 53,865,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0354,062,528 - 54,074,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,404,026 - 54,416,202 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WDR73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,914,048 - 53,927,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,914,619 - 53,927,034 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha356,554,244 - 56,566,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0354,334,301 - 54,347,044 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,333,081 - 54,347,015 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,853,220 - 53,865,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0354,062,528 - 54,074,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,404,026 - 54,416,202 (-)NCBIUU_Cfam_GSD_1.0
WDR73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381584,639,285 - 84,654,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1584,639,285 - 84,654,343 (-)EnsemblGRCh38hg38GRCh38
GRCh371585,182,516 - 85,197,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361582,987,003 - 82,998,525 (-)NCBINCBI36Build 36hg18NCBI36
Celera1561,611,526 - 61,623,048 (-)NCBICelera
Cytogenetic Map15q25.2NCBI
HuRef1561,271,897 - 61,283,419 (-)NCBIHuRef
CHM1_11585,027,130 - 85,038,652 (-)NCBICHM1_1
T2T-CHM13v2.01582,391,705 - 82,406,696 (-)NCBIT2T-CHM13v2.0
Wdr73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,540,471 - 80,551,017 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,540,471 - 80,551,017 (-)EnsemblGRCm39 Ensembl
GRCm38780,890,723 - 80,901,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,890,723 - 80,901,269 (-)EnsemblGRCm38mm10GRCm38
MGSCv37788,035,609 - 88,046,155 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,764,236 - 80,774,782 (-)NCBIMGSCv36mm8
Celera778,299,308 - 78,309,859 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.71NCBI
Wdr73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,269,561 - 144,277,707 (-)NCBIGRCr8
mRatBN7.21134,860,329 - 134,868,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,860,180 - 134,868,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,775,188 - 142,783,352 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,944,606 - 149,952,770 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,857,740 - 142,865,908 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,711,955 - 142,720,292 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,711,789 - 142,720,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,663,956 - 143,672,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,088,347 - 137,096,492 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,166,589 - 137,174,851 (-)NCBI
Celera1126,913,330 - 126,921,487 (-)NCBICelera
Cytogenetic Map1q31NCBI
Wdr73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,471,421 - 14,485,201 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,471,479 - 14,485,416 (+)NCBIChiLan1.0ChiLan1.0
WDR73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21673,595,848 - 73,610,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11577,814,222 - 77,827,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01563,310,497 - 63,322,064 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11582,633,080 - 82,645,833 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1582,633,080 - 82,645,833 (-)Ensemblpanpan1.1panPan2
Wdr73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,622,977 - 129,635,697 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,697,086 - 16,711,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,698,878 - 16,711,510 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,887,530 - 52,904,146 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,887,468 - 52,904,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
WDR73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1293,707,254 - 3,718,600 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl293,707,299 - 3,719,614 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605943,342,731 - 43,354,069 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,889,907 - 17,901,673 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,866,043 - 17,902,282 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WDR73
102 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 3
Low 5 5 19 6 6 6 6 6 9 8 10 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000020444   ⟹   ENSCAFP00000018971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl353,914,619 - 53,927,034 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063348   ⟹   ENSCAFP00000062057
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl353,914,619 - 53,926,664 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004970   ⟹   ENSCAFP00845003963
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl354,333,081 - 54,347,015 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004976   ⟹   ENSCAFP00845003966
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl354,333,081 - 54,346,624 (-)Ensembl
RefSeq Acc Id: XM_038471974   ⟹   XP_038327902
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1353,853,220 - 53,865,388 (-)NCBI
RefSeq Acc Id: XM_038532909   ⟹   XP_038388837
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0354,404,026 - 54,416,202 (-)NCBI
RefSeq Acc Id: XM_038597234   ⟹   XP_038453162
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0354,062,528 - 54,074,696 (-)NCBI
RefSeq Acc Id: XM_038597235   ⟹   XP_038453163
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0354,062,528 - 54,074,558 (-)NCBI
RefSeq Acc Id: XM_038661417   ⟹   XP_038517345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0354,334,301 - 54,347,044 (-)NCBI
RefSeq Acc Id: XM_846860   ⟹   XP_851953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1353,914,048 - 53,927,130 (-)NCBI
Dog10K_Boxer_Tasha356,554,244 - 56,566,623 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_851953   ⟸   XM_846860
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LYL3 (UniProtKB/TrEMBL),   A0A8C0KS84 (UniProtKB/TrEMBL),   A0A8I3MHW5 (UniProtKB/TrEMBL),   A0A8C0KWD7 (UniProtKB/TrEMBL),   A0A8C0LVJ4 (UniProtKB/TrEMBL),   A0A8C0Q0S4 (UniProtKB/TrEMBL),   A0A8I3MQQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000062057   ⟸   ENSCAFT00000063348
RefSeq Acc Id: ENSCAFP00000018971   ⟸   ENSCAFT00000020444
RefSeq Acc Id: XP_038327902   ⟸   XM_038471974
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038453162   ⟸   XM_038597234
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038453163   ⟸   XM_038597235
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038517345   ⟸   XM_038661417
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LYL3 (UniProtKB/TrEMBL),   A0A8C0KS84 (UniProtKB/TrEMBL),   A0A8I3MHW5 (UniProtKB/TrEMBL),   A0A8C0KWD7 (UniProtKB/TrEMBL),   A0A8C0LVJ4 (UniProtKB/TrEMBL),   A0A8C0Q0S4 (UniProtKB/TrEMBL),   A0A8I3MQQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038388837   ⟸   XM_038532909
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KS84 (UniProtKB/TrEMBL),   A0A8C0KWD7 (UniProtKB/TrEMBL),   A0A8C0LVJ4 (UniProtKB/TrEMBL),   A0A8C0LYL3 (UniProtKB/TrEMBL),   A0A8C0Q0S4 (UniProtKB/TrEMBL),   A0A8I3MHW5 (UniProtKB/TrEMBL),   A0A8I3MQQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003963   ⟸   ENSCAFT00845004970
RefSeq Acc Id: ENSCAFP00845003966   ⟸   ENSCAFT00845004976

Promoters
RGD ID:13682767
Promoter ID:EPDNEW_C833
Type:multiple initiation site
Name:WDR73_1
Description:WD repeat domain 73
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1353,927,043 - 53,927,103EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012877 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001435 UniProtKB/TrEMBL
  ENSCAFG00040003195 UniProtKB/TrEMBL
  ENSCAFG00845002803 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020444.5 UniProtKB/TrEMBL
  ENSCAFT00000063348.2 UniProtKB/TrEMBL
  ENSCAFT00030002551.1 UniProtKB/TrEMBL
  ENSCAFT00030002570.1 UniProtKB/TrEMBL
  ENSCAFT00040006055.1 UniProtKB/TrEMBL
  ENSCAFT00040006068.1 UniProtKB/TrEMBL
  ENSCAFT00845004970 ENTREZGENE
  ENSCAFT00845004970.1 UniProtKB/TrEMBL
  ENSCAFT00845004976.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  Wdr73 UniProtKB/TrEMBL
KEGG Report cfa:609576 UniProtKB/TrEMBL
NCBI Gene WDR73 ENTREZGENE
PANTHER PTHR46947 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 73 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0KS84 ENTREZGENE
  A0A8C0KWD7 ENTREZGENE
  A0A8C0LVJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LYL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q0S4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MHW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQQ7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48385 ENTREZGENE