TMX2 (thioredoxin related transmembrane protein 2) - Rat Genome Database

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Gene: TMX2 (thioredoxin related transmembrane protein 2) Pan paniscus
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Symbol: TMX2
Name: thioredoxin related transmembrane protein 2
RGD ID: 12040819
Description: ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); identical protein binding (inferred); INVOLVED IN brain development (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Nervous System Malformations (ortholog); FOUND IN mitochondria-associated endoplasmic reticulum membrane contact site (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thioredoxin-related transmembrane protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,868,933 - 58,895,226 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,888,902 - 59,915,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,953,360 - 52,979,685 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11156,423,679 - 56,449,402 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1156,423,772 - 56,449,402 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TMX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,868,933 - 58,895,226 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,888,902 - 59,915,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,953,360 - 52,979,685 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11156,423,679 - 56,449,402 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1156,423,772 - 56,449,402 (+)Ensemblpanpan1.1panPan2
TMX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,712,593 - 57,740,973 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,712,593 - 57,740,973 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,480,065 - 57,508,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,236,618 - 57,265,020 (+)NCBINCBI36Build 36hg18NCBI36
Celera1154,836,522 - 54,865,161 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,828,920 - 53,857,079 (+)NCBIHuRef
CHM1_11157,346,866 - 57,375,482 (+)NCBICHM1_1
T2T-CHM13v2.01157,662,769 - 57,691,303 (+)NCBIT2T-CHM13v2.0
Tmx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,501,655 - 84,509,172 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,501,660 - 84,509,484 (-)EnsemblGRCm39 Ensembl
GRCm38284,671,311 - 84,678,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,671,316 - 84,679,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,511,474 - 84,518,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,472,156 - 84,478,886 (-)NCBIMGSCv36mm8
Celera286,266,245 - 86,272,957 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
Tmx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,161,628 - 90,169,278 (-)NCBIGRCr8
mRatBN7.2369,754,937 - 69,762,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,754,939 - 69,762,587 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,136,661 - 73,144,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,735,324 - 81,743,057 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,494,318 - 79,501,977 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,073,429 - 72,081,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,073,431 - 72,081,079 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,594,075 - 78,601,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,880,726 - 67,888,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1367,777,099 - 67,784,748 (-)NCBI
Celera369,110,620 - 69,118,270 (-)NCBICelera
Cytogenetic Map3q24NCBI
Tmx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,632,507 - 2,638,763 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555112,632,434 - 2,641,531 (+)NCBIChiLan1.0ChiLan1.0
TMX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,480,976 - 38,490,424 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,481,264 - 38,490,326 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,027,870 - 38,037,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,162,866 - 39,172,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,162,869 - 39,172,210 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11838,745,935 - 38,755,452 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,319,088 - 38,328,606 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01838,949,712 - 38,959,141 (-)NCBIUU_Cfam_GSD_1.0
Tmx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,704,804 - 14,717,062 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365814,818,264 - 4,831,575 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365814,818,626 - 4,830,878 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,230,463 - 13,241,088 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,230,461 - 13,241,270 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,863,472 - 12,874,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,489,471 - 15,515,722 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,490,195 - 15,515,687 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038112,840,830 - 112,866,749 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,016,499 - 3,020,755 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248643,016,499 - 3,020,762 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000000202   ⟹   ENSPPAP00000000085
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1156,423,772 - 56,449,402 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000000205   ⟹   ENSPPAP00000000088
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1156,423,772 - 56,449,402 (+)Ensembl
RefSeq Acc Id: XM_014346821   ⟹   XP_014202307
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2958,868,933 - 58,895,226 (+)NCBI
NHGRI_mPanPan11159,888,902 - 59,915,197 (+)NCBI
Mhudiblu_PPA_v01152,953,392 - 52,979,685 (+)NCBI
PanPan1.11156,423,772 - 56,449,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024930787   ⟹   XP_024786555
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2958,891,857 - 58,895,226 (+)NCBI
NHGRI_mPanPan11159,911,828 - 59,915,197 (+)NCBI
Mhudiblu_PPA_v01152,953,360 - 52,979,685 (+)NCBI
PanPan1.11156,423,771 - 56,449,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063608183   ⟹   XP_063464253
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2958,870,285 - 58,895,226 (+)NCBI
RefSeq Acc Id: XM_063608184   ⟹   XP_063464254
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2958,868,933 - 58,893,476 (+)NCBI
Protein Sequences
Protein RefSeqs XP_014202307 (Get FASTA)   NCBI Sequence Viewer  
  XP_024786555 (Get FASTA)   NCBI Sequence Viewer  
  XP_063464253 (Get FASTA)   NCBI Sequence Viewer  
  XP_063464254 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000000085.1
  ENSPPAP00000000088.1
RefSeq Acc Id: XP_014202307   ⟸   XM_014346821
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZBT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024786555   ⟸   XM_024930787
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSPPAP00000000085   ⟸   ENSPPAT00000000202
RefSeq Acc Id: ENSPPAP00000000088   ⟸   ENSPPAT00000000205
RefSeq Acc Id: XP_063464254   ⟸   XM_063608184
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063464253   ⟸   XM_063608183
- Peptide Label: isoform X2
Protein Domains
Thioredoxin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000000127 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000000202.1 UniProtKB/TrEMBL
  ENSPPAT00000000205.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
  TMX2 UniProtKB/TrEMBL
  TMX2_thioredoxin_dom UniProtKB/TrEMBL
NCBI Gene TMX2 ENTREZGENE
PANTHER PTHR15853 UniProtKB/TrEMBL
  THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 2 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A2R8Z5U0_PANPA UniProtKB/TrEMBL
  A0A2R8ZBT7 ENTREZGENE, UniProtKB/TrEMBL