ACKR2 (atypical chemokine receptor 2)

Gene: ACKR2 (atypical chemokine receptor 2) Pan paniscus

Analyze

Symbol:

ACKR2

Name:

atypical chemokine receptor 2

RGD ID:

12009476

Description:

ENCODES a protein that exhibits C-C chemokine binding (inferred); C-C chemokine receptor activity (inferred); chemokine receptor activity (inferred); INVOLVED IN signal transduction (ortholog); ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy type A8 (ortholog); genetic disease (ortholog); FOUND IN actin filament (inferred); cytosol (inferred); early endosome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

CCBP2; chemokine binding protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,767,712 - 42,830,715 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,772,474 - 42,832,592 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,710,724 - 42,772,396 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	43,778,475 - 43,831,763 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	43,788,312 - 43,835,453 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital muscular dystrophy-dystroglycanopathy type A8 (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

cell chemotaxis (IEA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

G protein-coupled receptor signaling pathway (IEA)

immune response (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

signal transduction (IEA,ISO)

vesicle-mediated transport (IEA)

Cellular Component

actin filament (IEA)

cytosol (IEA)

early endosome (IEA)

endosome (IEA)

external side of plasma membrane (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

nuclear membrane (IEA)

nucleoplasm (IEA)

plasma membrane (IEA)

Molecular Function

C-C chemokine binding (IEA)

C-C chemokine receptor activity (IEA)

chemokine receptor activity (IEA)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

scavenger receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ACKR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,767,712 - 42,830,715 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,772,474 - 42,832,592 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,710,724 - 42,772,396 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	43,778,475 - 43,831,763 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	43,788,312 - 43,835,453 (+)	Ensembl	panpan1.1		panPan2

ACKR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	42,809,445 - 42,867,286 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	42,804,752 - 42,887,974 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	42,850,937 - 42,908,778 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	42,825,968 - 42,883,779 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	42,825,979 - 42,883,778	NCBI
Celera	3	42,788,881 - 42,846,689 (+)	NCBI		Celera
Cytogenetic Map	3	p22.1	NCBI
HuRef	3	42,894,146 - 42,951,926 (+)	NCBI		HuRef
CHM1_1	3	42,800,945 - 42,858,775 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	42,825,036 - 42,882,863 (+)	NCBI		T2T-CHM13v2.0

Ackr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	121,727,421 - 121,740,177 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	121,727,421 - 121,740,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	121,898,355 - 121,911,075 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	121,898,355 - 121,911,074 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	121,807,582 - 121,820,182 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	121,747,162 - 121,759,762 (+)	NCBI		MGSCv36	mm8
Celera	9	122,381,256 - 122,385,967 (+)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	72.71	NCBI

Ackr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	130,438,703 - 130,451,106 (+)	NCBI		GRCr8
mRatBN7.2	8	121,559,563 - 121,573,633 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	121,561,211 - 121,573,582 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	127,162,299 - 127,163,985 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	125,361,373 - 125,363,059 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	123,190,782 - 123,192,468 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	130,526,521 - 130,543,566 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	130,538,651 - 130,542,227 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	129,653,559 - 129,719,044 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	127,026,528 - 127,028,214 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	127,046,266 - 127,047,951 (-)	NCBI
Celera	8	120,695,513 - 120,697,199 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Ackr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	27,992,341 - 28,011,618 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	27,990,786 - 28,020,203 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACKR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	11,904,020 - 11,962,291 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	11,960,981 - 11,962,135 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	11,878,374 - 11,940,755 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	12,193,659 - 12,256,608 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	23	11,995,895 - 12,058,588 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	12,138,213 - 12,200,764 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	12,141,806 - 12,204,207 (+)	NCBI		UU_Cfam_GSD_1.0

Ackr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	199,920,315 - 199,978,872 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936695	2,273,797 - 2,274,951 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936695	2,272,978 - 2,274,982 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACKR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	26,288,584 - 26,329,581 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	26,291,583 - 26,329,506 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	28,974,396 - 28,993,716 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACKR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	4,272,340 - 4,313,929 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	4,312,645 - 4,313,799 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	162,884,569 - 162,900,086 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ackr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	76,901,098 - 76,902,219 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	76,900,112 - 76,918,805 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024928089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024928090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024928091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024928093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024928095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034956216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034956217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055109739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000037402 ⟹ ENSPPAP00000014715

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	43,788,312 - 43,835,453 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000037403 ⟹ ENSPPAP00000014716

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	43,788,312 - 43,835,453 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000037406 ⟹ ENSPPAP00000014719

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	43,819,424 - 43,835,453 (+)	Ensembl

RefSeq Acc Id:

XM_003809296 ⟹ XP_003809344

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	42,772,434 - 42,830,715 (+)	NCBI
NHGRI_mPanPan1	3	42,777,049 - 42,832,592 (+)	NCBI
Mhudiblu_PPA_v0	3	42,715,416 - 42,772,396 (+)	NCBI
PanPan1.1	3	43,778,475 - 43,831,763 (+)	NCBI

Sequence:

show sequence

TCTTTCGATTGTAGCATCTCTCCTTTCAGGATACAGTACAGGATCCTTTCTGGAATGGAGGTCT
TATGAGCTGCTATCGAACACGGCAGAGCCTGTTGGTGACCTGCACACAGGAGCCCTCCAGTCAG
TACTGATTGAATTACTCAAGGCTGCCTCTCTGCAAATTTGAGCACTACAGGACGTCGGGACTGG
GCACTTCCTTCCAACATGGCCGCCACTGCCTCTCCGCAGCCACTCACCACTGAGGATGCCGATT
CTGAGAATAGCAGCTTCTATTACTATGACTACCTGGATGAGGTGGCCTTCATGCTCTGCAGGAA
GGATGCAGTGGTGTCCTTTGGCAAAGTCTTCCTCCCAGTCTTCTATAGCCTGATTTTTGTGTTG
GGCCTCAGCGGGAACCTCCTTCTTCTCATGGTCTTGCTCCGTTACGTGCCTCGCAGGCGGATGG
TTGAGATCTATCTGCTGAATCTGGCCATCTCCAACCTTCTGTTTCTGGTGACACTGCCCTTCTG
GGGCATCTCCGTGGCCTGGCATTGGGTCTTCGGGAGTTTCTTGTGCAAGATGGTGAGCACTCTT
TATACTATTAACTTTTACAGTGGTATCTTTTTCATTAGCTGCATGAGCCTGGACAAGTACCTGG
AGATCGTTCATGCTCAGCCCTACCACAGGCTGAGGACCCGGGCCAAGAGCCTGCTCCTTGTTAC
CATAGTATGGGCTGTGTCCCTGGCCGTCTCCATCCCTGATATGGTCTTTGTACAGACACATGAA
AATCCCAAGGGTGTGTGGAACTGCCACGCAGATTTCGGCGGGCATGGGACCATTTGGAAGCTCT
TCCTCCGCTTCCAGCAGAACCTCCTAGGGTTTCTCCTTCCACTCCTTGCCATGATCTTCTTCTA
CTCCCGTATTGGTTGTGTCTTGGTGAGGCTGAGGCCCGCAGGCCAGGGCCGGGCTTTAAAAATA
GCTGCAGCCTTGGTGGTGGCCTTCTTCGTGCTATGGTTCCCATACAATCTCACCTTGTTTCTGC
ATACGCTGTTGGACCTGCAAGTATTCGGGAACTGTGAGGTCAGCCAGCATCTAGACTACGCACT
CCAGGTGACAGAGAGCATCGCCTTCCTTCACTGCTGCTTTTCCCCCATCCTGTATGCCTTCTCC
AGTCACCGCTTCCGCCAGTACCTGAAGGCTTTCCTGGCTGCTGTGCTTGGATGGCACCTGGCAC
CTGGCACTGCCCAGGCCTCATTATCCAGCTGTTCTGAGAGCAGCATACTTACTGCCCAAGAAGA
AATGACTGGCATGAATGACCTTGGAGAGAGGCAGTTTGAGAACTCCCCTAACAAGGAGGATGTG
GGGAATAAATCAGCCTGAGTGACC

hide sequence

RefSeq Acc Id:

XM_055109739 ⟹ XP_054965714

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	42,767,712 - 42,830,715 (+)	NCBI
NHGRI_mPanPan1	3	42,772,474 - 42,832,592 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003809344	(Get FASTA)	NCBI Sequence Viewer
	XP_054965714	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000014715.1
	ENSPPAP00000014716.1
	ENSPPAP00000014719.1

RefSeq Acc Id:

XP_003809344 ⟸ XM_003809296

- UniProtKB:

A0A2R9ABS7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAATASPQPLTTEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGN
LLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINF
YSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLVTIVWAVSLAVSIPDMVFVQTHENPKGV
WNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALV
VAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFR
QYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQFENSPNKEDVGNKSA

hide sequence

RefSeq Acc Id:

ENSPPAP00000014719 ⟸ ENSPPAT00000037406

RefSeq Acc Id:

ENSPPAP00000014715 ⟸ ENSPPAT00000037402

RefSeq Acc Id:

ENSPPAP00000014716 ⟸ ENSPPAT00000037403

RefSeq Acc Id:

XP_054965714 ⟸ XM_055109739

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000030527	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000037402.1	UniProtKB/TrEMBL
	ENSPPAT00000037403.1	UniProtKB/TrEMBL
	ENSPPAT00000037406.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Chemokine_rcpt	UniProtKB/TrEMBL
	CXCR4/ACKR2	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	ACKR2	ENTREZGENE
PANTHER	ATYPICAL CHEMOKINE RECEPTOR 2	UniProtKB/TrEMBL
	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	CCCHEMOKINER	UniProtKB/TrEMBL
	CXCCHMKINER4	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R9ABS7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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