PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4) - Rat Genome Database

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Gene: PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4) Pan paniscus
Analyze
Symbol: PLEKHG4
Name: pleckstrin homology and RhoGEF domain containing G4
RGD ID: 12008731
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); spinocerebellar ataxia type 31 (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: puratrophin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,804,149 - 76,818,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,720,546 - 82,731,397 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,623,234 - 47,634,704 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,013,034 - 67,023,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,013,926 - 67,023,917 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PLEKHG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,804,149 - 76,818,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,720,546 - 82,731,397 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,623,234 - 47,634,704 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,013,034 - 67,023,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,013,926 - 67,023,917 (+)Ensemblpanpan1.1panPan2
PLEKHG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,277,580 - 67,289,480 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,277,510 - 67,289,499 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,312,065 - 67,323,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,868,914 - 65,880,884 (+)NCBINCBI36Build 36hg18NCBI36
Celera1651,819,638 - 51,831,669 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,184,495 - 53,196,466 (+)NCBIHuRef
CHM1_11668,718,769 - 68,730,759 (+)NCBICHM1_1
T2T-CHM13v2.01673,071,877 - 73,083,777 (+)NCBIT2T-CHM13v2.0
Plekhg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,096,272 - 106,109,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,099,906 - 106,109,494 (+)EnsemblGRCm39 Ensembl
GRCm388105,369,640 - 105,382,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,373,274 - 105,382,862 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,899,281 - 107,906,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,264,510 - 108,271,991 (+)NCBIMGSCv36mm8
Celera8109,598,528 - 109,606,009 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Plekhg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,161,722 - 50,176,491 (+)NCBIGRCr8
mRatBN7.21933,251,788 - 33,266,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,249,706 - 33,266,357 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01937,327,395 - 37,345,047 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,330,930 - 37,345,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,195,669 - 48,210,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,190,188 - 35,197,607 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,190,890 - 35,202,169 (+)NCBI
Celera1932,677,414 - 32,695,066 (+)NCBICelera
Cytogenetic Map19q12NCBI
Plekhg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554849,344,830 - 9,356,182 (-)NCBIChiLan1.0ChiLan1.0
PLEKHG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,075,536 - 82,102,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,075,852 - 82,102,168 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,082,780 - 82,092,426 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,528,434 - 82,538,080 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,510,764 - 82,537,406 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,354,537 - 82,364,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,040,113 - 82,049,760 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,679,358 - 82,689,004 (-)NCBIUU_Cfam_GSD_1.0
Plekhg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,829,897 - 41,856,261 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647517,737,734 - 17,746,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,923,617 - 27,933,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,921,598 - 27,932,680 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,188,898 - 25,226,383 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,157,217 - 60,177,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl560,163,553 - 60,174,765 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,910,275 - 22,930,175 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474619,037,195 - 19,046,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000065305   ⟹   ENSPPAP00000042375
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1667,013,926 - 67,023,917 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000065306   ⟹   ENSPPAP00000042376
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1667,014,470 - 67,023,225 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000065308   ⟹   ENSPPAP00000042378
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1667,014,470 - 67,023,225 (+)Ensembl
RefSeq Acc Id: XM_055100321   ⟹   XP_054956296
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21876,804,149 - 76,818,746 (+)NCBI
NHGRI_mPanPan11682,720,546 - 82,731,397 (+)NCBI
RefSeq Acc Id: XM_055100323   ⟹   XP_054956298
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21876,808,408 - 76,818,746 (+)NCBI
NHGRI_mPanPan11682,721,321 - 82,731,397 (+)NCBI
RefSeq Acc Id: XM_055100325   ⟹   XP_054956300
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21876,808,409 - 76,818,746 (+)NCBI
NHGRI_mPanPan11682,721,321 - 82,731,397 (+)NCBI
Protein Sequences
Protein RefSeqs XP_054956296 (Get FASTA)   NCBI Sequence Viewer  
  XP_054956298 (Get FASTA)   NCBI Sequence Viewer  
  XP_054956300 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000042375.1
  ENSPPAP00000042376.1
  ENSPPAP00000042378.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000042378   ⟸   ENSPPAT00000065308
RefSeq Acc Id: ENSPPAP00000042376   ⟸   ENSPPAT00000065306
RefSeq Acc Id: ENSPPAP00000042375   ⟸   ENSPPAT00000065305
RefSeq Acc Id: XP_054956296   ⟸   XM_055100321
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054956298   ⟸   XM_055100323
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CK95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054956300   ⟸   XM_055100325
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CK76 (UniProtKB/TrEMBL)
Protein Domains
DH   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043758 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065305.1 UniProtKB/TrEMBL
  ENSPPAT00000065306.1 UniProtKB/TrEMBL
  ENSPPAT00000065308.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene PLEKHG4 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF52087 UniProtKB/TrEMBL
UniProt A0A2R9CK76 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CK95 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CMT1_PANPA UniProtKB/TrEMBL