WFDC12 (WAP four-disulfide core domain 12) - Rat Genome Database

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Gene: WFDC12 (WAP four-disulfide core domain 12) Pan paniscus
Analyze
Symbol: WFDC12
Name: WAP four-disulfide core domain 12
RGD ID: 11989481
Description: ENCODES a protein that exhibits peptidase inhibitor activity (inferred); INVOLVED IN defense response to bacterium (ortholog); ASSOCIATED WITH focal epilepsy (ortholog); genetic disease (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WAP four-disulfide core domain protein 12
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,855,651 - 50,857,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,848,849 - 50,850,509 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,453,282 - 41,454,943 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,546,058 - 42,547,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,546,058 - 42,547,092 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
WFDC12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,855,651 - 50,857,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,848,849 - 50,850,509 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,453,282 - 41,454,943 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,546,058 - 42,547,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,546,058 - 42,547,092 (-)Ensemblpanpan1.1panPan2
WFDC12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,123,425 - 45,124,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,123,425 - 45,124,465 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,752,066 - 43,753,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,185,481 - 43,186,520 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,185,480 - 43,186,520NCBI
Celera2040,460,700 - 40,461,739 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,493,959 - 40,494,998 (-)NCBIHuRef
CHM1_12043,654,810 - 43,655,849 (-)NCBICHM1_1
T2T-CHM13v2.02046,859,329 - 46,860,369 (-)NCBIT2T-CHM13v2.0
Wfdc12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,031,151 - 164,032,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,031,151 - 164,032,528 (-)EnsemblGRCm39 Ensembl
GRCm382164,189,231 - 164,190,558 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,189,231 - 164,190,608 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,014,967 - 164,016,294 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,880,672 - 163,881,999 (-)NCBIMGSCv36mm8
Celera2170,120,783 - 170,122,110 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.6NCBI
Wfdc12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,280,844 - 173,282,167 (-)NCBIGRCr8
mRatBN7.23152,861,461 - 152,862,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,862,341 - 152,862,690 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,669,830 - 156,670,179 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,168,771 - 165,169,120 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,914,112 - 162,914,462 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,581,449 - 160,581,798 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,581,449 - 160,581,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,765,632 - 166,766,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,130,095 - 155,130,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,036,148 - 155,036,480 (-)NCBI
Celera3151,510,431 - 151,510,780 (-)NCBICelera
Cytogenetic Map3q42NCBI
LOC102151692
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,531,619 - 32,545,712 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,187,067 - 32,190,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,252,531 - 33,256,102 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12432,513,807 - 32,517,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,629,200 - 32,632,770 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,170,964 - 33,174,536 (+)NCBIUU_Cfam_GSD_1.0
LOC110598145
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,196,214 - 192,197,507 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365147,650,114 - 7,651,139 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100512873
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11747,579,081 - 47,581,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,182,954 - 53,185,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WFDC12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,693,251 - 18,694,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,693,580 - 18,694,182 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,342,030 - 67,342,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003825949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000000105   ⟹   ENSPPAP00000000054
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2042,546,058 - 42,547,092 (-)Ensembl
RefSeq Acc Id: XM_003825949   ⟹   XP_003825997
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,855,651 - 50,857,402 (-)NCBI
NHGRI_mPanPan12050,848,849 - 50,850,509 (-)NCBI
Mhudiblu_PPA_v02041,453,282 - 41,454,943 (-)NCBI
PanPan1.12042,546,058 - 42,547,092 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003825997 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000000054.1
Reference Protein Sequences
RefSeq Acc Id: XP_003825997   ⟸   XM_003825949
- Sequence:
RefSeq Acc Id: ENSPPAP00000000054   ⟸   ENSPPAT00000000105
Protein Domains
WAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000000101 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000000105.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  WAP_dom UniProtKB/TrEMBL
  WFDC8/12/15B-like UniProtKB/TrEMBL
KEGG Report pps:100985162 UniProtKB/TrEMBL
NCBI Gene WFDC12 ENTREZGENE
PANTHER WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8 UniProtKB/TrEMBL
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8 UniProtKB/TrEMBL
Pfam WAP UniProtKB/TrEMBL
PRINTS 4DISULPHCORE UniProtKB/TrEMBL
PROSITE WAP UniProtKB/TrEMBL
SMART WAP UniProtKB/TrEMBL
Superfamily-SCOP SSF57256 UniProtKB/TrEMBL
UniProt A0A2R8Z9I4_PANPA UniProtKB/TrEMBL