STAP1 (signal transducing adaptor family member 1)

Gene: STAP1 (signal transducing adaptor family member 1) Pan paniscus

Analyze

Symbol:

STAP1

Name:

signal transducing adaptor family member 1

RGD ID:

11975582

Description:

ENCODES a protein that exhibits macrophage colony-stimulating factor receptor binding (inferred); phosphotyrosine residue binding (inferred); protein kinase binding (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); response to bacterium (ortholog); ASSOCIATED WITH familial hypercholesterolemia (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN centriolar satellite (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

signal-transducing adaptor protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	62,285,361 - 62,338,376 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	62,498,436 - 62,546,159 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	56,442,773 - 56,491,148 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	62,835,845 - 62,882,222 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	62,836,288 - 62,882,570 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial hypercholesterolemia (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor protein tyrosine kinase signaling pathway (IEA,ISO)

cellular response to lipopolysaccharide (IEA)

negative regulation of macrophage chemotaxis (IEA)

negative regulation of macrophage colony-stimulating factor signaling pathway (IEA)

negative regulation of microglial cell migration (IEA)

negative regulation of ruffle assembly (IEA)

positive regulation of B cell receptor signaling pathway (IEA)

positive regulation of gene expression (IEA)

positive regulation of microglial cell activation (IEA)

positive regulation of microglial cell mediated cytotoxicity (IEA)

positive regulation of phagocytosis, engulfment (IEA)

response to bacterium (IEA,ISO)

Cellular Component

centriolar satellite (IEA)

cytoplasm (IEA)

cytosol (IEA)

mitochondrion (IEA)

nucleoplasm (IEA)

nucleus (IEA)

protein-containing complex (IEA)

Molecular Function

macrophage colony-stimulating factor receptor binding (IEA)

phosphotyrosine residue binding (IEA)

protein binding (ISO)

protein kinase binding (IEA)

protein tyrosine kinase activator activity (IEA)

protein-macromolecule adaptor activity (IEA)

receptor tyrosine kinase binding (IEA)

signaling adaptor activity (IEA)

transmembrane receptor protein tyrosine kinase adaptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

STAP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	62,285,361 - 62,338,376 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	62,498,436 - 62,546,159 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	56,442,773 - 56,491,148 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	62,835,845 - 62,882,222 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	62,836,288 - 62,882,570 (-)	Ensembl	panpan1.1		panPan2

STAP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	67,558,727 - 67,607,337 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	67,558,727 - 67,607,337 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	68,424,445 - 68,473,055 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	68,107,041 - 68,155,211 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	65,886,843 - 65,935,009 (+)	NCBI		Celera
Cytogenetic Map	4	q13.2	NCBI
HuRef	4	64,337,610 - 64,385,777 (+)	NCBI		HuRef
CHM1_1	4	68,461,613 - 68,509,764 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	71,001,810 - 71,050,419 (+)	NCBI		T2T-CHM13v2.0

Stap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	86,219,446 - 86,251,859 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	86,219,605 - 86,253,984 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	86,071,584 - 86,106,125 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	86,071,746 - 86,106,125 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	86,500,853 - 86,533,018 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	87,146,389 - 87,178,554 (+)	NCBI		MGSCv36	mm8
Celera	5	83,303,792 - 83,335,974 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	43.56	NCBI

Stap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	22,301,278 - 22,336,218 (-)	NCBI		GRCr8
mRatBN7.2	14	21,950,466 - 21,981,395 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,952,496 - 21,981,245 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	22,309,093 - 22,337,798 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,621,523 - 23,650,227 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	22,152,622 - 22,181,325 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	23,575,400 - 23,604,984 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	23,576,085 - 23,604,834 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	23,479,674 - 23,508,287 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	23,734,558 - 23,764,077 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	23,734,558 - 23,764,077 (-)	NCBI
Celera	14	21,426,012 - 21,455,282 (-)	NCBI		Celera
Cytogenetic Map	14	p21	NCBI

Stap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	5,293,227 - 5,330,187 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955447	5,292,708 - 5,345,214 (-)	NCBI	ChiLan1.0	ChiLan1.0

STAP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	58,091,457 - 58,148,902 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	58,091,477 - 58,133,711 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	58,007,105 - 58,063,908 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	58,702,648 - 58,759,950 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	58,702,657 - 58,746,463 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	58,428,932 - 58,485,817 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	57,919,165 - 57,976,003 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	58,929,330 - 58,986,417 (+)	NCBI		UU_Cfam_GSD_1.0

Stap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	18,314,644 - 18,350,598 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936582	877,474 - 913,770 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936582	877,241 - 908,697 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STAP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	65,332,522 - 65,392,965 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	65,318,861 - 65,372,838 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	69,756,934 - 69,797,692 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STAP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	1,330,761 - 1,380,503 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	1,330,223 - 1,379,820 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666066	1,417,432 - 1,466,864 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	1,361,498 - 1,409,674 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	1,361,271 - 1,409,548 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003815808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034958719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000048787 ⟹ ENSPPAP00000025956

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	62,836,288 - 62,882,570 (-)	Ensembl

RefSeq Acc Id:

XM_003815808 ⟹ XP_003815856

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	62,285,361 - 62,338,376 (-)	NCBI
NHGRI_mPanPan1	4	62,498,436 - 62,546,157 (-)	NCBI
Mhudiblu_PPA_v0	4	56,442,773 - 56,491,148 (-)	NCBI
PanPan1.1	4	62,835,845 - 62,882,222 (-)	NCBI

Sequence:

show sequence

GGTTAAAAAGCAATTTGGGACTTCCTCTTTGAACAGTTGCCTTTTCCTCTCACAGAAGGAAGAT
TTCATTTTGTTTGAAACGAGAAACCAAACCACACACCAAAGAGAGGGGTATGATGGCTAAGAAG
CCCCCAAAACCAGCCCCTCGCAGGATCTTCCAGGAAAGGTTAAAGATTACTGCTCTACCTTTGT
ACTTTGAAGGTTTTTTATTAATCAAGAGGTCAGGATACCGGGAGTATGAGCATTACTGGACAGA
GTTGAGAGGAACTACTCTTTTCTTTTATACCGAGAAAAAGAGTATAATATATGTTGACAAATTA
GACATAGTAGACCTCACATGCCTTACTGAGCAGAATTCAACTGAAAAGAACTGTGCGAAATTCA
CCCTTGTTTTGCCGAAAGAGGAAGTACAACTGAAGACAGAGAACACAGAAAGTGGGGAAGAATG
GAGAGGCTTCATTCTTACAGTAACAGAGCTGTCAGTTCCCCAAAATGTGTCACTCCTACCTGGG
CAAGTAATTAAACTGCATGAAGTCCTAGAGAGAGAAAAGAAAAGGAGGATTGAGACAGAGCAGA
GTACGTCCGTGGAAAAAGAGAAGGAACCAACTGAAGATTATGTGGATGTACTGAACCCTATGCC
AGCATGTTTTTATACAGTGTCCCGGAAAGAGGCAACTGAGATGCTCCAGAAGAACCCTTCTTTG
GGAAATATGATCCTGAGGCCTGGTAGTGACAGTAGAAACTACTCCATCACTATTCGGCAGGAGA
TAGACATTCCAAGAATCAAGCACTACAAAGTGATGAGCGTAGGACAAAACTACACTATTGAACT
GGAAAAACCTGTAACACTCCCAAACCTTTTCAGTGTCATTGATTATTTTGTGAAGGAGACTCGA
GGAAATTTAAGACCATTTATATGTTCAACTGATGAAAACACTGGTCAAGAACCCAGTATGGAAG
GGAGAAGTGAAAAGTTGAAGAAAAATCCACACATTGCATGAAATACAATGTGAAAGCTCCTTTG
TGTATCTTGGTAATTTATATTTTCAAAACGAAGTTCTTACTTTTAAAGAGAATTACCTATATTC
TCCTGATACTGATTACCAAGTCATTCACCCGAACACCAGAATTAGAATTAAACATTGTACCATA
CAATTTCATTATCTTATCAGAATGAAACCAATTCACAGGGAAACTAGAGACTACGGCTGTGGTG
GTAACCTGCAGATATACACATTCCCATGCACTGACATAAGTTGAAAACACATAGTACTTTCTAG
ATGGAATTTTTTTCTTTAGGCCTCAATGAAATACATTTCCCCTATATAATTCCAACAGCAGTTT
CTCTAGTTCTAAATTCTACCAATTCCCAAAAAACCTAAGTTTTGCTGAAATCTGATTTGACCAA
TTTATCAAATGTCATTTTAATTACCTAGCTGGAAGTTAGAGACATGAAATGTACTAGAGGAGCC
CTTTTCCAATGGAAATATTATATACCACATTTTTTGTTAATGGAAATAAATGTCTCCATTCCCA
TGTTTTTCCCTGGTGTCATCTTTTTGCCACTCAAAATCAGCCCATTATTTCCTTACAAAGATCG
TGAAAGGCTGTATCATCATCTTGTGTCGTAAGTACGATAAGCCTGATTATAAGTACCCGGAGTT
CTTAAAAATATGGAACCATCAGCCCCAGACTGCATCTACTGAATCAAAATAACGGATATTTTTT
CATAATTTTTTTCTTCAAAAGCAAACTTCTAAATTGATTTTGATGGTTATCAATTTGGGAATCA
CACAATCAACTAAGAATGAAAAGATATGGTCTATATTCTACAGGGGAAAGACTATGTGAGACAG
AGGGAGAAAACAGCCATTGACAACTCAAGGAGAGAGGCCTCGGGGGGAAAAAAAGATCAACCTG
GCCAAAACCTTGAAAATCCGGCTTCTTGACTTGTGAGAAAATAAATTTGTGTTCCTTAATCCA

hide sequence

RefSeq Acc Id:

XM_034958719 ⟹ XP_034814610

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	62,285,361 - 62,338,376 (-)	NCBI
NHGRI_mPanPan1	4	62,498,436 - 62,546,159 (-)	NCBI
Mhudiblu_PPA_v0	4	56,442,773 - 56,491,148 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003815856	(Get FASTA)	NCBI Sequence Viewer
	XP_034814610	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000025956
	ENSPPAP00000025956.1

RefSeq Acc Id:	XP_003815856 ⟸ XM_003815808
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BCD6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMAKKPPKPAPRRIFQERLKITALPLYFEGFLLIKRSGYREYEHYWTELRGTTLFFYTEKKSII YVDKLDIVDLTCLTEQNSTEKNCAKFTLVLPKEEVQLKTENTESGEEWRGFILTVTELSVPQNV SLLPGQVIKLHEVLEREKKRRIETEQSTSVEKEKEPTEDYVDVLNPMPACFYTVSRKEATEMLQ KNPSLGNMILRPGSDSRNYSITIRQEIDIPRIKHYKVMSVGQNYTIELEKPVTLPNLFSVIDYF VKETRGNLRPFICSTDENTGQEPSMEGRSEKLKKNPHIA hide sequence

RefSeq Acc Id:	XP_034814610 ⟸ XM_034958719
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSPPAP00000025956 ⟸ ENSPPAT00000048787

Protein Domains

PH SH2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036102	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000048787.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
InterPro	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	STAP1/STAP2	UniProtKB/TrEMBL
	STAP1_SH2	UniProtKB/TrEMBL
KEGG Report	pps:100995627	UniProtKB/TrEMBL
NCBI Gene	STAP1	ENTREZGENE
PANTHER	PTHR16186	UniProtKB/TrEMBL
	SIGNAL-TRANSDUCING ADAPTOR PROTEIN 1	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A0A2R9BCD6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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