ASXL1 (ASXL transcriptional regulator 1) - Rat Genome Database

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Gene: ASXL1 (ASXL transcriptional regulator 1) Pan paniscus
Analyze
Symbol: ASXL1
Name: ASXL transcriptional regulator 1
RGD ID: 11929952
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN animal organ morphogenesis (ortholog); bone development (ortholog); bone marrow development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); atypical chronic myeloid leukemia (ortholog); FOUND IN PR-DUB complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: additional sex combs like 1, transcriptional regulator; polycomb group protein ASXL1; putative Polycomb group protein ASXL1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22138,038,565 - 38,130,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,043,027 - 38,123,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,647,004 - 28,727,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,773,836 - 29,852,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,774,582 - 29,850,453 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)
PR-DUB complex  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22138,038,565 - 38,130,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,043,027 - 38,123,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,647,004 - 28,727,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,773,836 - 29,852,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,774,582 - 29,850,453 (+)Ensemblpanpan1.1panPan2
ASXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382032,358,331 - 32,439,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2032,358,330 - 32,439,319 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,946,134 - 31,027,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,409,814 - 30,490,783 (+)NCBINCBI36Build 36hg18NCBI36
Build 342030,409,820 - 30,490,783NCBI
Celera2027,702,183 - 27,783,146 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,742,560 - 27,816,603 (+)NCBIHuRef
CHM1_12030,850,605 - 30,932,052 (+)NCBICHM1_1
T2T-CHM13v2.02034,083,215 - 34,164,178 (+)NCBIT2T-CHM13v2.0
Asxl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,187,750 - 153,245,927 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,187,749 - 153,245,927 (+)EnsemblGRCm39 Ensembl
GRCm382153,345,830 - 153,404,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,345,829 - 153,404,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,171,875 - 153,229,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,037,493 - 153,095,448 (+)NCBIMGSCv36mm8
MGSCv362154,151,679 - 154,209,986 (+)NCBIMGSCv36mm8
Celera2159,188,615 - 159,246,403 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Asxl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,273,828 - 162,341,742 (+)NCBIGRCr8
mRatBN7.23141,814,012 - 141,881,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,813,433 - 141,881,538 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03148,832,231 - 148,902,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,837,814 - 148,900,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,202,740 - 155,267,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,703,295 - 143,767,523 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3140,560,551 - 140,627,551 (+)NCBICelera
Cytogenetic Map3q41NCBI
Asxl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,664,282 - 28,721,896 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,662,392 - 28,721,896 (-)NCBIChiLan1.0ChiLan1.0
ASXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,725,126 - 21,804,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,661,059 - 21,802,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,372,658 - 21,451,415 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02422,413,734 - 22,492,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,414,540 - 22,493,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,690,505 - 21,768,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,797,741 - 21,876,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,228,633 - 22,307,459 (+)NCBIUU_Cfam_GSD_1.0
Asxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,792,007 - 170,865,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648519,227,400 - 19,298,912 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648519,218,494 - 19,297,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,985,535 - 36,067,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,985,978 - 36,067,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,908,208 - 40,984,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASXL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,735,449 - 36,810,447 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,735,830 - 36,812,387 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,099,728 - 90,176,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asxl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741188,745 - 250,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741188,985 - 258,065 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003814739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003814741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034947561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055104462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055104463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055104464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055104465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055104466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055104467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000032265   ⟹   ENSPPAP00000009622
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2029,774,582 - 29,850,453 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032268   ⟹   ENSPPAP00000009625
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2029,774,582 - 29,786,859 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032269   ⟹   ENSPPAP00000009626
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2029,781,260 - 29,850,453 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032274   ⟹   ENSPPAP00000009631
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2029,781,287 - 29,786,477 (+)Ensembl
RefSeq Acc Id: XM_003814741   ⟹   XP_003814789
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,050,865 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,043,964 - 38,123,069 (+)NCBI
Mhudiblu_PPA_v02028,647,833 - 28,727,865 (+)NCBI
PanPan1.12029,773,836 - 29,852,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034947556   ⟹   XP_034803447
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,038,573 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,043,151 - 38,123,069 (+)NCBI
Mhudiblu_PPA_v02028,647,133 - 28,727,865 (+)NCBI
RefSeq Acc Id: XM_055104462   ⟹   XP_054960437
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,038,565 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,043,146 - 38,123,069 (+)NCBI
RefSeq Acc Id: XM_055104463   ⟹   XP_054960438
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,050,865 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,043,963 - 38,123,069 (+)NCBI
RefSeq Acc Id: XM_055104464   ⟹   XP_054960439
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,058,396 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,051,573 - 38,123,069 (+)NCBI
RefSeq Acc Id: XM_055104465   ⟹   XP_054960440
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,038,566 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,043,146 - 38,123,069 (+)NCBI
RefSeq Acc Id: XM_055104466   ⟹   XP_054960441
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,038,573 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,043,151 - 38,123,069 (+)NCBI
RefSeq Acc Id: XM_055104467   ⟹   XP_054960442
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22138,060,945 - 38,130,871 (+)NCBI
NHGRI_mPanPan12038,054,044 - 38,123,069 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003814789   ⟸   XM_003814741
- Peptide Label: isoform X8
- UniProtKB: A0A2R8ZXC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034803447   ⟸   XM_034947556
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZXC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000009631   ⟸   ENSPPAT00000032274
RefSeq Acc Id: ENSPPAP00000009626   ⟸   ENSPPAT00000032269
RefSeq Acc Id: ENSPPAP00000009625   ⟸   ENSPPAT00000032268
RefSeq Acc Id: ENSPPAP00000009622   ⟸   ENSPPAT00000032265
RefSeq Acc Id: XP_054960437   ⟸   XM_055104462
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054960440   ⟸   XM_055104465
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054960441   ⟸   XM_055104466
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054960438   ⟸   XM_055104463
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054960439   ⟸   XM_055104464
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054960442   ⟸   XM_055104467
- Peptide Label: isoform X7
Protein Domains
DEUBAD   HTH HARE-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028038 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032265.1 UniProtKB/TrEMBL
  ENSPPAT00000032268.1 UniProtKB/TrEMBL
  ENSPPAT00000032269.1 UniProtKB/TrEMBL
  ENSPPAT00000032274.1 UniProtKB/TrEMBL
InterPro ASX-like_PHD UniProtKB/TrEMBL
  ASX/ASX-like UniProtKB/TrEMBL
  ASX_DEUBAD_dom UniProtKB/TrEMBL
  Asxl_HARE-HTH UniProtKB/TrEMBL
  DEUBAD_dom UniProtKB/TrEMBL
NCBI Gene ASXL1 ENTREZGENE
PANTHER PTHR13578 UniProtKB/TrEMBL
  PTHR13578:SF19 UniProtKB/TrEMBL
Pfam ASXH UniProtKB/TrEMBL
  HARE-HTH UniProtKB/TrEMBL
  PHD_3 UniProtKB/TrEMBL
PROSITE DEUBAD UniProtKB/TrEMBL
  HTH_HARE UniProtKB/TrEMBL
UniProt A0A2R8ZXC0_PANPA UniProtKB/TrEMBL
  A0A2R8ZXC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZXC8_PANPA UniProtKB/TrEMBL
  A0A2R8ZYH4_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-15 ASXL1  ASXL transcriptional regulator 1    additional sex combs like 1, transcriptional regulator  Symbol and/or name change 5135510 APPROVED