A2ML1 (alpha-2-macroglobulin like 1) - Rat Genome Database

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Gene: A2ML1 (alpha-2-macroglobulin like 1) Pan paniscus
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Symbol: A2ML1
Name: alpha-2-macroglobulin like 1
RGD ID: 11893627
Description: ENCODES a protein that exhibits endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 21 (ortholog); genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-2-macroglobulin-like protein 1; LOC100980318; LOC100989752
RGD Orthologs
Human
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21014,350,503 - 14,406,468 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,347,263 - 14,403,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,909,111 - 8,961,857 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,123,524 - 9,193,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,122,447 - 9,192,371 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
A2ML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21014,350,503 - 14,406,468 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,347,263 - 14,403,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,909,111 - 8,961,857 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,123,524 - 9,193,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,122,447 - 9,192,371 (+)Ensemblpanpan1.1panPan2
A2ML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,822,621 - 8,887,459 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,822,621 - 8,887,001 (+)EnsemblGRCh38hg38GRCh38
GRCh37128,975,217 - 9,029,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,866,417 - 8,920,646 (+)NCBINCBI36Build 36hg18NCBI36
Celera1210,512,687 - 10,566,801 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef128,757,142 - 8,810,010 (+)NCBIHuRef
CHM1_1128,944,605 - 8,997,761 (+)NCBICHM1_1
T2T-CHM13v2.0128,805,910 - 8,869,474 (+)NCBIT2T-CHM13v2.0
A2ML1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,844,292 - 36,882,274 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2736,844,572 - 36,883,887 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,742,223 - 9,772,407 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,193,157 - 37,223,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,193,455 - 37,233,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,073,782 - 37,103,765 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,108,930 - 37,138,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,250,894 - 9,303,905 (+)NCBIUU_Cfam_GSD_1.0
A2ML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,609,408 - 62,648,400 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,603,260 - 62,648,170 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,445,120 - 65,497,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
A2ML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,638,320 - 8,695,696 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,638,826 - 8,693,355 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666089734,884 - 784,242 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048606   ⟹   ENSPPAP00000025776
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl129,122,447 - 9,192,371 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000048607   ⟹   ENSPPAP00000025777
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl129,144,745 - 9,192,371 (+)Ensembl
RefSeq Acc Id: XM_055095361   ⟹   XP_054951336
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21014,370,912 - 14,406,468 (+)NCBI
NHGRI_mPanPan11214,367,681 - 14,403,228 (+)NCBI
RefSeq Acc Id: XM_055095362   ⟹   XP_054951337
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21014,370,912 - 14,402,825 (+)NCBI
NHGRI_mPanPan11214,367,681 - 14,399,585 (+)NCBI
RefSeq Acc Id: XM_055095363   ⟹   XP_054951338
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21014,370,912 - 14,402,825 (+)NCBI
NHGRI_mPanPan11214,367,681 - 14,399,585 (+)NCBI
RefSeq Acc Id: XM_057299373   ⟹   XP_057155356
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21014,350,882 - 14,406,468 (+)NCBI
NHGRI_mPanPan11214,347,641 - 14,403,228 (+)NCBI
RefSeq Acc Id: XM_057299374   ⟹   XP_057155357
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21014,370,912 - 14,406,468 (+)NCBI
NHGRI_mPanPan11214,367,681 - 14,403,228 (+)NCBI
RefSeq Acc Id: XM_057299375   ⟹   XP_057155358
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21014,350,503 - 14,406,468 (+)NCBI
NHGRI_mPanPan11214,347,263 - 14,403,228 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000025777   ⟸   ENSPPAT00000048607
RefSeq Acc Id: ENSPPAP00000025776   ⟸   ENSPPAT00000048606
RefSeq Acc Id: XP_054951336   ⟸   XM_055095361
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B9K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054951338   ⟸   XM_055095363
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B9K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054951337   ⟸   XM_055095362
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B9K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057155358   ⟸   XM_057299375
- Peptide Label: isoform X5
- UniProtKB: A0A2R9BBW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057155356   ⟸   XM_057299373
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BBW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057155357   ⟸   XM_057299374
- Peptide Label: isoform X4
- UniProtKB: A0A2R9B9K8 (UniProtKB/TrEMBL)
Protein Domains
Alpha-2-macroglobulin   Alpha-2-macroglobulin bait region   Alpha-macroglobulin receptor-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036011 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048606.1 UniProtKB/TrEMBL
  ENSPPAT00000048607.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/TrEMBL
  2.20.130.20 UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/TrEMBL
  6.20.50.160 UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/TrEMBL
  A2M_TED UniProtKB/TrEMBL
  Alpha-macroglob_thiol-ester_cl UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
NCBI Gene LOC100980318 ENTREZGENE
PANTHER ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1 UniProtKB/TrEMBL
  MACROGLOBULIN / COMPLEMENT UniProtKB/TrEMBL
Pfam A2M UniProtKB/TrEMBL
  A2M_BRD UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  TED_complement UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/TrEMBL
SMART A2M UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  Thiol-ester_cl UniProtKB/TrEMBL
Superfamily-SCOP SSF48239 UniProtKB/TrEMBL
  SSF49410 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A2R9B9K8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BBW6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-08 A2ML1  alpha-2-macroglobulin like 1  LOC100989752  alpha-2-macroglobulin-like protein 1  Data merged from RGD:12017158 737654 PROVISIONAL
2018-05-08 A2ML1  alpha-2-macroglobulin like 1  LOC100980318  alpha-2-macroglobulin-like protein 1  Symbol and/or name change 5135510 APPROVED