MIS12 (MIS12 kinetochore complex component) - Rat Genome Database

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Gene: MIS12 (MIS12 kinetochore complex component) Pan paniscus
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Symbol: MIS12
Name: MIS12 kinetochore complex component
RGD ID: 11885015
Description: INVOLVED IN attachment of mitotic spindle microtubules to kinetochore (inferred); chromosome segregation (inferred); kinetochore assembly (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 25 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN chromosome (inferred); chromosome, centromeric region (inferred); kinetochore (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MIS12, kinetochore complex component; MIS12, MIND kinetochore complex component, homolog; protein MIS12 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,096,460 - 13,100,927 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,064,884 - 15,069,147 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,534,305 - 5,538,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,526,376 - 5,530,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,529,017 - 5,529,634 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MIS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,096,460 - 13,100,927 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,064,884 - 15,069,147 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,534,305 - 5,538,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,526,376 - 5,530,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,529,017 - 5,529,634 (+)Ensemblpanpan1.1panPan2
MIS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,486,374 - 5,490,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,486,285 - 5,490,814 (+)EnsemblGRCh38hg38GRCh38
GRCh37175,389,694 - 5,394,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,330,971 - 5,334,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 34175,330,970 - 5,334,852NCBI
Celera175,406,624 - 5,410,507 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,279,942 - 5,284,378 (+)NCBIHuRef
CHM1_1175,399,363 - 5,403,803 (+)NCBICHM1_1
T2T-CHM13v2.0175,380,118 - 5,384,558 (+)NCBIT2T-CHM13v2.0
Mis12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,910,394 - 70,918,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,910,437 - 70,918,197 (+)EnsemblGRCm39 Ensembl
GRCm381171,019,568 - 71,027,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,019,611 - 71,027,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,833,113 - 70,840,636 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,835,806 - 70,843,329 (+)NCBIMGSCv36mm8
Celera1178,574,026 - 78,581,549 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
Mis12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,238,317 - 56,246,491 (+)NCBIGRCr8
mRatBN7.21055,739,741 - 55,747,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,739,564 - 55,751,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,419,384 - 60,427,548 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,907,903 - 59,916,067 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,406,993 - 55,415,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,653,685 - 57,661,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,660,067 - 57,660,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,398,658 - 57,407,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,927,346 - 57,928,594 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1054,891,204 - 54,892,452 (+)NCBICelera
Cytogenetic Map10q24NCBI
Mis12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,837,832 - 10,842,123 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,837,570 - 10,842,131 (+)NCBIChiLan1.0ChiLan1.0
MIS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,314,067 - 31,319,392 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,452,291 - 31,457,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,418,896 - 31,424,159 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,418,275 - 31,424,080 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,384,435 - 31,389,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,343,365 - 31,348,624 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,519,760 - 31,525,016 (-)NCBIUU_Cfam_GSD_1.0
Mis12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,572,281 - 53,577,485 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366772,323,540 - 2,328,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,505,381 - 51,507,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,505,376 - 51,508,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MIS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,897,672 - 4,902,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605916,684,905 - 16,689,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mis12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,285,830 - 9,289,454 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,285,475 - 9,289,659 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000007641   ⟹   ENSPPAP00000001560
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl175,529,017 - 5,529,634 (+)Ensembl
RefSeq Acc Id: XM_003810163   ⟹   XP_003810211
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21913,096,460 - 13,100,927 (+)NCBI
NHGRI_mPanPan11715,064,884 - 15,069,147 (+)NCBI
Mhudiblu_PPA_v0175,534,305 - 5,538,736 (+)NCBI
PanPan1.1175,526,376 - 5,530,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003810164   ⟹   XP_003810212
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21913,096,508 - 13,100,927 (+)NCBI
NHGRI_mPanPan11715,064,884 - 15,069,147 (+)NCBI
Mhudiblu_PPA_v0175,534,309 - 5,538,736 (+)NCBI
PanPan1.1175,526,376 - 5,530,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055101017   ⟹   XP_054956992
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21913,096,674 - 13,100,927 (+)NCBI
NHGRI_mPanPan11715,064,892 - 15,069,147 (+)NCBI
RefSeq Acc Id: XM_055101018   ⟹   XP_054956993
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21913,097,039 - 13,100,927 (+)NCBI
NHGRI_mPanPan11715,064,892 - 15,069,147 (+)NCBI
RefSeq Acc Id: XM_063598924   ⟹   XP_063454994
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21913,097,032 - 13,100,927 (+)NCBI
RefSeq Acc Id: XM_063598926   ⟹   XP_063454996
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21913,096,991 - 13,100,927 (+)NCBI
RefSeq Acc Id: XP_003810212   ⟸   XM_003810164
- UniProtKB: A0A2R8Z9A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003810211   ⟸   XM_003810163
- UniProtKB: A0A2R8Z9A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000001560   ⟸   ENSPPAT00000007641
RefSeq Acc Id: XP_054956992   ⟸   XM_055101017
- UniProtKB: A0A2R8Z9A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054956993   ⟸   XM_055101018
- UniProtKB: A0A2R8Z9A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063454996   ⟸   XM_063598926
- UniProtKB: A0A2R8Z9A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063454994   ⟸   XM_063598924
- UniProtKB: A0A2R8Z9A0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000007020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000007641.1 UniProtKB/TrEMBL
InterPro Centromere_Mis12 UniProtKB/TrEMBL
KEGG Report pps:100976067 UniProtKB/TrEMBL
NCBI Gene MIS12 ENTREZGENE
PANTHER PROTEIN MIS12 HOMOLOG UniProtKB/TrEMBL
  PTHR14527 UniProtKB/TrEMBL
Pfam Mis12 UniProtKB/TrEMBL
UniProt A0A2R8Z9A0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 MIS12  MIS12 kinetochore complex component    MIS12, kinetochore complex component  Symbol and/or name change 5135510 APPROVED