DESI2 (desumoylating isopeptidase 2) - Rat Genome Database

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Gene: DESI2 (desumoylating isopeptidase 2) Pan paniscus
Analyze
Symbol: DESI2
Name: desumoylating isopeptidase 2
RGD ID: 11879441
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); deubiquitinase activity (inferred); hydrolase activity (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 54 (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: deubiquitinase DESI2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214,448,197 - 4,507,060 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114,670,620 - 4,726,951 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01220,246,390 - 220,302,577 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,626,913 - 225,682,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,626,913 - 225,682,772 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DESI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214,448,197 - 4,507,060 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114,670,620 - 4,726,951 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01220,246,390 - 220,302,577 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,626,913 - 225,682,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,626,913 - 225,682,772 (+)Ensemblpanpan1.1panPan2
DESI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,653,126 - 244,709,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,653,103 - 244,709,033 (+)EnsemblGRCh38hg38GRCh38
GRCh371244,816,428 - 244,872,335 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361242,882,975 - 242,938,958 (+)NCBINCBI36Build 36hg18NCBI36
Celera1218,106,243 - 218,162,211 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1215,199,549 - 215,255,506 (+)NCBIHuRef
CHM1_11246,088,656 - 246,144,628 (+)NCBICHM1_1
T2T-CHM13v2.01244,069,385 - 244,125,271 (+)NCBIT2T-CHM13v2.0
Desi2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,014,983 - 178,080,164 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,014,983 - 178,084,867 (+)EnsemblGRCm39 Ensembl
GRCm381178,187,417 - 178,252,598 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,187,417 - 178,257,301 (+)EnsemblGRCm38mm10GRCm38
MGSCv371180,117,548 - 180,182,729 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361180,024,385 - 180,089,269 (+)NCBIMGSCv36mm8
Celera1185,247,627 - 185,312,483 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map182.93NCBI
Desi2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81392,493,765 - 92,543,307 (+)NCBIGRCr8
mRatBN7.21389,961,767 - 90,011,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1389,961,934 - 90,016,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1392,467,195 - 92,510,053 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01393,867,337 - 93,910,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01391,048,646 - 91,091,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01396,111,800 - 96,156,693 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1396,111,800 - 96,154,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,553,747 - 100,599,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41393,895,171 - 93,903,458 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11394,084,106 - 94,092,392 (+)NCBI
Celera1389,520,725 - 89,563,808 (+)NCBICelera
Cytogenetic Map13q25NCBI
Desi2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554067,880,648 - 7,894,629 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554067,881,815 - 7,894,690 (+)NCBIChiLan1.0ChiLan1.0
DESI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1735,688,519 - 35,734,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl735,687,888 - 35,731,186 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha735,161,634 - 35,208,048 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0735,516,735 - 35,563,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl735,516,660 - 35,563,350 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1735,352,288 - 35,398,850 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0735,367,194 - 35,413,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0735,632,821 - 35,679,443 (+)NCBIUU_Cfam_GSD_1.0
Desi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934448,566,633 - 48,617,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365266,129,500 - 6,180,668 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365266,130,714 - 6,180,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DESI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1017,365,689 - 17,416,635 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11017,365,649 - 17,416,642 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21019,696,102 - 19,747,165 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DESI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,670,135 - 81,733,696 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2581,670,170 - 81,733,812 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605583,892,549 - 83,956,201 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Desi2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477114,879,277 - 14,927,002 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477114,879,275 - 14,927,352 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000049074   ⟹   ENSPPAP00000026241
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1225,626,913 - 225,682,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049081   ⟹   ENSPPAP00000026248
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1225,626,970 - 225,679,541 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049085   ⟹   ENSPPAP00000026252
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1225,627,411 - 225,682,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049088   ⟹   ENSPPAP00000026255
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1225,658,333 - 225,679,541 (+)Ensembl
RefSeq Acc Id: XM_003807991   ⟹   XP_003808039
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214,448,197 - 4,507,060 (-)NCBI
NHGRI_mPanPan114,670,620 - 4,726,809 (-)NCBI
Mhudiblu_PPA_v01220,246,390 - 220,302,577 (+)NCBI
PanPan1.11225,626,913 - 225,682,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960092   ⟹   XP_008958340
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214,448,197 - 4,504,563 (-)NCBI
NHGRI_mPanPan114,670,620 - 4,726,951 (-)NCBI
Mhudiblu_PPA_v01220,247,043 - 220,302,577 (+)NCBI
PanPan1.11225,627,266 - 225,682,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960093   ⟹   XP_008958341
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214,448,197 - 4,475,334 (-)NCBI
NHGRI_mPanPan114,670,620 - 4,697,742 (-)NCBI
Mhudiblu_PPA_v01220,275,468 - 220,302,577 (+)NCBI
PanPan1.11225,655,694 - 225,682,778 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003808039   ⟸   XM_003807991
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BD75 (UniProtKB/TrEMBL),   A0A2R9BH80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008958340   ⟸   XM_008960092
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BH80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008958341   ⟸   XM_008960093
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BH80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000026241   ⟸   ENSPPAT00000049074
RefSeq Acc Id: ENSPPAP00000026255   ⟸   ENSPPAT00000049088
RefSeq Acc Id: ENSPPAP00000026252   ⟸   ENSPPAT00000049085
RefSeq Acc Id: ENSPPAP00000026248   ⟸   ENSPPAT00000049081
Protein Domains
PPPDE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036240 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049074.1 UniProtKB/TrEMBL
  ENSPPAT00000049081.1 UniProtKB/TrEMBL
  ENSPPAT00000049085.1 UniProtKB/TrEMBL
  ENSPPAT00000049088.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1720.30 UniProtKB/TrEMBL
InterPro PPPDE_dom UniProtKB/TrEMBL
  PPPDE_sf UniProtKB/TrEMBL
KEGG Report pps:100993407 UniProtKB/TrEMBL
NCBI Gene DESI2 ENTREZGENE
PANTHER DEUBIQUITINASE DESI2 UniProtKB/TrEMBL
  PTHR12378 UniProtKB/TrEMBL
Pfam Peptidase_C97 UniProtKB/TrEMBL
PROSITE PPPDE UniProtKB/TrEMBL
SMART DUF862 UniProtKB/TrEMBL
UniProt A0A2R9B9I8_PANPA UniProtKB/TrEMBL
  A0A2R9BAX7_PANPA UniProtKB/TrEMBL
  A0A2R9BD75 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BH80 ENTREZGENE, UniProtKB/TrEMBL