BID (BH3 interacting domain death agonist) - Rat Genome Database

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Pathways
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Gene: BID (BH3 interacting domain death agonist) Pan paniscus
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Symbol: BID
Name: BH3 interacting domain death agonist
RGD ID: 11877660
Description: ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); glial cell apoptotic process (ortholog); hepatocyte apoptotic process (ortholog); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); bronchopulmonary dysplasia (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BH3-interacting domain death agonist
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,052,191 - 28,092,158 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12230,600,920 - 30,639,767 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,164,787 - 1,205,051 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12216,594,186 - 16,633,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2216,594,186 - 16,632,844 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic mitochondrial changes  (IEA)
apoptotic process  (IEA)
establishment of protein localization to membrane  (IEA)
extrinsic apoptotic signaling pathway  (IEA,ISO)
glial cell apoptotic process  (ISO)
hepatocyte apoptotic process  (IEA,ISO)
mitochondrial ATP synthesis coupled electron transport  (IEA,ISO)
mitochondrial outer membrane permeabilization  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA)
positive regulation of mitochondrial membrane potential  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of release of cytochrome c from mitochondria  (IEA)
protein targeting to mitochondrion  (IEA,ISO)
protein-containing complex assembly  (IEA)
regulation of apoptotic process  (IEA,ISO)
regulation of apoptotic signaling pathway  (IEA)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
regulation of mitochondrial membrane permeability involved in apoptotic process  (IEA,ISO)
regulation of T cell proliferation  (IEA,ISO)
release of cytochrome c from mitochondria  (IEA,ISO)
response to estradiol  (ISO)
response to ischemia  (ISO)
response to stress  (IEA)
supramolecular fiber organization  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BID
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,052,191 - 28,092,158 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12230,600,920 - 30,639,767 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,164,787 - 1,205,051 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12216,594,186 - 16,633,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2216,594,186 - 16,632,844 (-)Ensemblpanpan1.1panPan2
BID
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382217,734,138 - 17,774,665 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2217,734,138 - 17,774,770 (-)EnsemblGRCh38hg38GRCh38
GRCh372218,216,904 - 18,257,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,596,906 - 16,637,258 (-)NCBINCBI36Build 36hg18NCBI36
Build 342216,591,459 - 16,631,812NCBI
Celera221,836,614 - 1,876,916 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,030,888 - 2,070,940 (-)NCBIHuRef
CHM1_12218,216,448 - 18,257,021 (-)NCBICHM1_1
T2T-CHM13v2.02218,401,873 - 18,442,340 (-)NCBIT2T-CHM13v2.0
Bid
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396120,870,080 - 120,894,074 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6120,868,891 - 120,893,814 (-)EnsemblGRCm39 Ensembl
GRCm386120,893,119 - 120,917,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6120,891,930 - 120,916,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv376120,843,137 - 120,866,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366120,858,738 - 120,882,439 (-)NCBIMGSCv36mm8
Celera6122,736,915 - 122,760,652 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.02NCBI
Bid
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84155,785,366 - 155,808,775 (-)NCBIGRCr8
mRatBN7.24154,113,198 - 154,136,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,113,198 - 154,134,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4160,379,868 - 160,401,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,163,607 - 156,185,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04154,786,934 - 154,808,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04153,439,812 - 153,465,247 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4153,442,218 - 153,465,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04220,531,866 - 220,554,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44157,296,383 - 157,318,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14157,541,223 - 157,563,322 (-)NCBI
Celera4142,956,454 - 142,978,221 (-)NCBICelera
Cytogenetic Map4q42NCBI
Bid
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554545,777,667 - 5,783,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554545,776,656 - 5,785,500 (-)NCBIChiLan1.0ChiLan1.0
BID
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12745,344,304 - 45,355,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2745,337,145 - 45,384,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha271,299,470 - 1,338,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02745,714,410 - 45,753,866 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2745,714,410 - 45,753,879 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12745,642,533 - 45,681,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02745,615,826 - 45,655,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.027652,469 - 692,311 (+)NCBIUU_Cfam_GSD_1.0
Bid
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945110,195,950 - 110,237,745 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936807708,276 - 750,093 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936807708,340 - 750,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BID
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl569,849,002 - 69,875,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1569,849,007 - 69,874,647 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2572,118,716 - 72,143,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Bid
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247359,579,979 - 9,589,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247359,557,732 - 9,590,862 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000034188   ⟹   ENSPPAP00000011530
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2216,594,186 - 16,632,844 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034191   ⟹   ENSPPAP00000011533
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2216,599,457 - 16,610,423 (-)Ensembl
RefSeq Acc Id: XM_003828293   ⟹   XP_003828341
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22328,052,191 - 28,091,654 (-)NCBI
NHGRI_mPanPan12230,600,920 - 30,639,273 (-)NCBI
Mhudiblu_PPA_v0221,164,789 - 1,204,576 (-)NCBI
PanPan1.12216,594,186 - 16,632,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034948680   ⟹   XP_034804571
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22328,052,191 - 28,092,148 (-)NCBI
NHGRI_mPanPan12230,600,920 - 30,639,767 (-)NCBI
Mhudiblu_PPA_v0221,164,787 - 1,205,051 (-)NCBI
RefSeq Acc Id: XM_034948681   ⟹   XP_034804572
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22328,052,191 - 28,092,158 (-)NCBI
NHGRI_mPanPan12230,600,920 - 30,639,765 (-)NCBI
Mhudiblu_PPA_v0221,164,787 - 1,205,043 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003828341 (Get FASTA)   NCBI Sequence Viewer  
  XP_034804571 (Get FASTA)   NCBI Sequence Viewer  
  XP_034804572 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011530.1
  ENSPPAP00000011533.1
Reference Protein Sequences
RefSeq Acc Id: XP_003828341   ⟸   XM_003828293
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034804571   ⟸   XM_034948680
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034804572   ⟸   XM_034948681
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000011533   ⟸   ENSPPAT00000034191
RefSeq Acc Id: ENSPPAP00000011530   ⟸   ENSPPAT00000034188


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034188.1 UniProtKB/TrEMBL
  ENSPPAT00000034191.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
InterPro Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/TrEMBL
  BID UniProtKB/TrEMBL
KEGG Report pps:100989555 UniProtKB/TrEMBL
NCBI Gene BID ENTREZGENE
PANTHER BH3-INTERACTING DOMAIN DEATH AGONIST UniProtKB/TrEMBL
  PTHR35447 UniProtKB/TrEMBL
Pfam BID UniProtKB/TrEMBL
PIRSF BID UniProtKB/TrEMBL
PROSITE BH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt A0A2R9A2N2_PANPA UniProtKB/TrEMBL
  A0A2R9A786_PANPA UniProtKB/TrEMBL