PRKRA (protein activator of interferon induced protein kinase EIF2AK2) - Rat Genome Database

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Pathways
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Gene: PRKRA (protein activator of interferon induced protein kinase EIF2AK2) Pan paniscus
Analyze
Symbol: PRKRA
Name: protein activator of interferon induced protein kinase EIF2AK2
RGD ID: 11854885
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); ear development (ortholog); middle ear morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness 59 (ortholog); Congenital Microtia (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN cytoplasm (ortholog); RISC-loading complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interferon-inducible double-stranded RNA-dependent protein kinase activator A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,079,378 - 81,098,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,094,352 - 81,113,838 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,689,029 - 65,708,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,393,819 - 183,413,174 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B183,393,819 - 183,413,174 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
RISC complex  (IEA)
RISC-loading complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PRKRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,079,378 - 81,098,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,094,352 - 81,113,838 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,689,029 - 65,708,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,393,819 - 183,413,174 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B183,393,819 - 183,413,174 (-)Ensemblpanpan1.1panPan2
PRKRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382178,431,414 - 178,451,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2178,431,292 - 178,451,512 (-)EnsemblGRCh38hg38GRCh38
GRCh372179,296,141 - 179,315,902 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362179,004,395 - 179,024,110 (-)NCBINCBI36Build 36hg18NCBI36
Build 342179,121,656 - 179,141,371NCBI
Celera2172,899,027 - 172,918,844 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2171,166,825 - 171,186,642 (-)NCBIHuRef
CHM1_12179,302,152 - 179,321,965 (-)NCBICHM1_1
T2T-CHM13v2.02178,914,206 - 178,933,968 (-)NCBIT2T-CHM13v2.0
Prkra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,436,385 - 76,478,614 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,460,242 - 76,478,359 (-)EnsemblGRCm39 Ensembl
GRCm38276,609,215 - 76,648,220 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,629,898 - 76,648,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv37276,467,994 - 76,486,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36276,430,776 - 76,448,833 (-)NCBIMGSCv36mm8
Celera278,291,609 - 78,309,670 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map245.07NCBI
Prkra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,982,669 - 82,002,028 (-)NCBIGRCr8
mRatBN7.2361,575,447 - 61,594,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,575,447 - 61,594,347 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx364,929,458 - 64,949,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0373,513,107 - 73,533,316 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0371,280,761 - 71,300,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0363,489,081 - 63,507,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl363,489,074 - 63,507,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0370,062,242 - 70,081,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4359,327,653 - 59,346,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1359,224,026 - 59,242,883 (-)NCBI
Celera361,061,241 - 61,080,098 (-)NCBICelera
Cytogenetic Map3q24NCBI
Prkra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540318,373,375 - 18,410,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540318,394,609 - 18,410,381 (+)NCBIChiLan1.0ChiLan1.0
PRKRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13622,061,226 - 22,080,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3622,061,461 - 22,080,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3622,079,633 - 22,098,744 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03622,204,685 - 22,224,038 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13622,314,310 - 22,333,404 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03622,276,900 - 22,296,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03622,393,174 - 22,412,535 (-)NCBIUU_Cfam_GSD_1.0
Prkra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303139,099,289 - 139,115,053 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365097,653,047 - 7,668,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365097,653,192 - 7,668,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1584,133,687 - 84,156,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11584,134,273 - 84,156,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,668,054 - 93,690,407 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11063,982,784 - 64,003,919 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040135,571,753 - 135,592,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624844410,461 - 424,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624844410,461 - 424,833 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000064309   ⟹   ENSPPAP00000041383
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B183,393,819 - 183,413,174 (-)Ensembl
RefSeq Acc Id: XM_003815512   ⟹   XP_003815560
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21381,079,378 - 81,098,864 (-)NCBI
NHGRI_mPanPan12B81,094,352 - 81,113,838 (-)NCBI
Mhudiblu_PPA_v02B65,689,029 - 65,708,491 (-)NCBI
PanPan1.12B183,393,819 - 183,413,174 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024927902   ⟹   XP_024783670
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21381,079,378 - 81,094,809 (-)NCBI
NHGRI_mPanPan12B81,094,352 - 81,109,783 (-)NCBI
Mhudiblu_PPA_v02B65,689,078 - 65,703,313 (-)NCBI
PanPan1.12B183,393,819 - 183,408,129 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034954586   ⟹   XP_034810477
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21381,079,378 - 81,095,127 (-)NCBI
NHGRI_mPanPan12B81,094,352 - 81,113,607 (-)NCBI
Mhudiblu_PPA_v02B65,689,078 - 65,708,327 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003815560 (Get FASTA)   NCBI Sequence Viewer  
  XP_024783670 (Get FASTA)   NCBI Sequence Viewer  
  XP_034810477 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000041383.1
Reference Protein Sequences
RefSeq Acc Id: XP_003815560   ⟸   XM_003815512
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024783670   ⟸   XM_024927902
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034810477   ⟸   XM_034954586
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000041383   ⟸   ENSPPAT00000064309
Protein Domains
DRBM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043306 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000064309.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.160.20 UniProtKB/TrEMBL
InterPro dsRBD_dom UniProtKB/TrEMBL
  PRKRA_DSRM_1 UniProtKB/TrEMBL
  PRKRA_DSRM_2 UniProtKB/TrEMBL
NCBI Gene PRKRA ENTREZGENE
PANTHER LOQUACIOUS, ISOFORM B UniProtKB/TrEMBL
  PTHR46205:SF2 UniProtKB/TrEMBL
Pfam dsrm UniProtKB/TrEMBL
PROSITE DS_RBD UniProtKB/TrEMBL
SMART DSRM UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
UniProt A0A2R9CK60_PANPA UniProtKB/TrEMBL