CCN4 (cellular communication network factor 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CCN4 (cellular communication network factor 4) Pan paniscus
Analyze
Symbol: CCN4
Name: cellular communication network factor 4
RGD ID: 11849645
Description: ENCODES a protein that exhibits heparin binding (inferred); integrin binding (inferred); INVOLVED IN positive regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of smooth muscle cell migration (ortholog); positive regulation of smooth muscle cell proliferation (ortholog); ASSOCIATED WITH Airway Remodeling (ortholog); benign neonatal seizures (ortholog); Charcot-Marie-Tooth disease type 4 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular matrix (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CCN family member 4; WISP1; WNT1 inducible signaling pathway protein 1; WNT1-inducible-signaling pathway protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27150,576,117 - 150,619,035 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18126,090,690 - 126,133,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08129,842,580 - 129,884,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18132,818,397 - 132,858,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,818,397 - 132,858,861 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27150,576,117 - 150,619,035 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18126,090,690 - 126,133,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08129,842,580 - 129,884,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18132,818,397 - 132,858,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,818,397 - 132,858,861 (+)Ensemblpanpan1.1panPan2
CCN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388133,191,039 - 133,231,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8133,191,039 - 133,231,690 (+)EnsemblGRCh38hg38GRCh38
GRCh378134,203,282 - 134,243,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,272,494 - 134,310,753 (+)NCBINCBI36Build 36hg18NCBI36
Build 348134,272,493 - 134,309,234NCBI
Celera8130,380,567 - 130,419,496 (+)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8129,522,987 - 129,563,677 (+)NCBIHuRef
CHM1_18134,244,050 - 134,284,955 (+)NCBICHM1_1
T2T-CHM13v2.08134,314,374 - 134,355,795 (+)NCBIT2T-CHM13v2.0
Ccn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,763,337 - 66,795,050 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1566,763,169 - 66,795,050 (+)EnsemblGRCm39 Ensembl
GRCm381566,891,369 - 66,923,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,891,320 - 66,923,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371566,722,955 - 66,754,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361566,721,062 - 66,752,868 (+)NCBIMGSCv36mm8
Celera1568,424,047 - 68,455,874 (+)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
Ccn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,534,578 - 100,566,287 (+)NCBIGRCr8
mRatBN7.2798,645,238 - 98,677,253 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,645,182 - 98,677,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7100,410,333 - 100,438,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,612,004 - 102,640,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,531,335 - 102,559,884 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,695,227 - 107,723,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,695,215 - 107,723,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07107,644,976 - 107,673,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47104,263,089 - 104,291,621 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17104,297,318 - 104,325,846 (+)NCBI
Celera795,196,524 - 95,225,037 (+)NCBICelera
Cytogenetic Map7q33NCBI
Ccn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554617,748,005 - 7,780,427 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554617,748,399 - 7,780,359 (+)NCBIChiLan1.0ChiLan1.0
CCN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11329,648,720 - 29,683,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1329,648,639 - 29,679,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1329,622,701 - 29,661,265 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01330,004,803 - 30,043,373 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1330,004,755 - 30,039,284 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11329,731,434 - 29,769,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01329,830,792 - 29,869,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01330,180,453 - 30,219,020 (+)NCBIUU_Cfam_GSD_1.0
Ccn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053038,682,581 - 8,708,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647016,110,497 - 16,134,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647016,110,492 - 16,134,065 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,079,755 - 8,110,700 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.148,078,163 - 8,110,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,188,614 - 8,216,061 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18127,620,635 - 127,658,132 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8127,642,598 - 127,661,462 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603912,440,154 - 12,481,049 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473522,788,475 - 22,819,648 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473522,789,784 - 22,819,527 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000062662   ⟹   ENSPPAP00000039750
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl8132,818,397 - 132,858,861 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062666   ⟹   ENSPPAP00000039754
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl8132,818,503 - 132,854,971 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062667   ⟹   ENSPPAP00000039755
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl8132,818,503 - 132,854,971 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062669   ⟹   ENSPPAP00000039757
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl8132,818,503 - 132,854,790 (+)Ensembl
RefSeq Acc Id: XM_003830085   ⟹   XP_003830133
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v27150,576,117 - 150,619,035 (+)NCBI
NHGRI_mPanPan18126,090,690 - 126,133,538 (+)NCBI
Mhudiblu_PPA_v08129,842,580 - 129,884,528 (+)NCBI
PanPan1.18132,818,397 - 132,858,861 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063606915   ⟹   XP_063462985
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v27150,576,118 - 150,619,035 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003830133 (Get FASTA)   NCBI Sequence Viewer  
  XP_063462985 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000039750
  ENSPPAP00000039750.1
  ENSPPAP00000039754.1
  ENSPPAP00000039755.1
  ENSPPAP00000039757.1
Reference Protein Sequences
RefSeq Acc Id: XP_003830133   ⟸   XM_003830085
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CCT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000039757   ⟸   ENSPPAT00000062669
RefSeq Acc Id: ENSPPAP00000039754   ⟸   ENSPPAT00000062666
RefSeq Acc Id: ENSPPAP00000039755   ⟸   ENSPPAT00000062667
RefSeq Acc Id: ENSPPAP00000039750   ⟸   ENSPPAT00000062662
RefSeq Acc Id: XP_063462985   ⟸   XM_063606915
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CD04 (UniProtKB/TrEMBL)
Protein Domains
CTCK   IGFBP N-terminal   VWFC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042561 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062662.1 UniProtKB/TrEMBL
  ENSPPAT00000062666.1 UniProtKB/TrEMBL
  ENSPPAT00000062667.1 UniProtKB/TrEMBL
  ENSPPAT00000062669.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  IGFBP-like UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
KEGG Report pps:100990243 UniProtKB/TrEMBL
NCBI Gene WISP1 ENTREZGENE
PANTHER CCN FAMILY MEMBER 4 UniProtKB/TrEMBL
  CONNECTIVE TISSUE GROWTH FACTOR-RELATED UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
  IGFBP UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PIRSF IGFBP_rP_CNN UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  IGFBP_N_1 UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
  SM00121 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A2R9CCT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CCU3_PANPA UniProtKB/TrEMBL
  A0A2R9CD04 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CNF8_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-16 CCN4  cellular communication network factor 4  WISP1  WNT1 inducible signaling pathway protein 1  Symbol and/or name change 5135510 APPROVED