MCF2 (MCF.2 cell line derived transforming sequence) - Rat Genome Database

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Gene: MCF2 (MCF.2 cell line derived transforming sequence) Pan paniscus
Analyze
Symbol: MCF2
Name: MCF.2 cell line derived transforming sequence
RGD ID: 11829467
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); dendrite development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Failure to Thrive (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene DBL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X139,031,267 - 139,143,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X139,034,869 - 139,147,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X128,737,271 - 128,848,384 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X138,985,456 - 139,047,015 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX138,984,632 - 139,096,066 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MCF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X139,031,267 - 139,143,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X139,034,869 - 139,147,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X128,737,271 - 128,848,384 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X138,985,456 - 139,047,015 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX138,984,632 - 139,096,066 (-)Ensemblpanpan1.1panPan2
MCF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X139,581,770 - 139,708,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX139,581,770 - 139,708,216 (-)EnsemblGRCh38hg38GRCh38
GRCh37X138,663,929 - 138,790,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X138,491,596 - 138,618,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X138,389,449 - 138,450,372NCBI
CeleraX139,031,369 - 139,157,817 (-)NCBICelera
Cytogenetic MapXq27.1NCBI
HuRefX127,931,315 - 128,057,565 (-)NCBIHuRef
CHM1_1X138,574,821 - 138,701,280 (-)NCBICHM1_1
T2T-CHM13v2.0X137,890,836 - 138,020,159 (-)NCBIT2T-CHM13v2.0
Mcf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X59,101,316 - 59,224,546 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX59,101,316 - 59,224,449 (-)EnsemblGRCm39 Ensembl
GRCm38X60,055,956 - 60,179,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX60,055,956 - 60,179,089 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X57,309,133 - 57,400,820 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X56,402,743 - 56,494,427 (-)NCBIMGSCv36mm8
CeleraX46,495,004 - 46,586,548 (-)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX33.5NCBI
Mcf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X143,444,510 - 143,550,839 (-)NCBIGRCr8
mRatBN7.2X138,414,077 - 138,514,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX138,409,256 - 138,514,446 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X143,159,071 - 143,292,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX143,154,209 - 143,274,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X143,188,541 - 143,236,007 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X145,597,430 - 145,693,790 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX134,485,013 - 134,591,931 (-)NCBICelera
Cytogenetic MapXq36NCBI
Mcf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554895,665,530 - 5,709,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554895,613,310 - 5,715,688 (+)NCBIChiLan1.0ChiLan1.0
MCF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X109,543,609 - 109,627,265 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX109,545,245 - 109,627,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX95,370,950 - 95,454,589 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X111,530,138 - 111,601,036 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX111,530,151 - 111,601,032 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X108,664,168 - 108,747,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X110,848,683 - 110,932,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X110,528,154 - 110,611,768 (-)NCBIUU_Cfam_GSD_1.0
Mcf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X107,580,518 - 107,707,380 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365137,922,700 - 8,034,793 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365137,950,082 - 8,035,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX114,258,074 - 114,356,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X114,258,082 - 114,356,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X130,456,205 - 130,575,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X114,670,397 - 114,795,400 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX114,670,454 - 114,776,957 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606552,394,633 - 52,527,358 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248087,009,996 - 7,116,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248087,010,020 - 7,116,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000045697   ⟹   ENSPPAP00000022883
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,984,632 - 139,096,066 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045703   ⟹   ENSPPAP00000022889
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,984,632 - 139,096,066 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045708   ⟹   ENSPPAP00000022893
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,984,632 - 139,047,221 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045718   ⟹   ENSPPAP00000022903
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,985,456 - 139,047,010 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045720   ⟹   ENSPPAP00000022905
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,985,456 - 139,047,010 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045721   ⟹   ENSPPAP00000022906
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,986,160 - 139,055,889 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045724   ⟹   ENSPPAP00000022909
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX138,988,078 - 139,039,481 (-)Ensembl
RefSeq Acc Id: XM_003812303   ⟹   XP_003812351
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,094,427 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,098,033 (-)NCBI
Mhudiblu_PPA_v0X128,737,271 - 128,799,250 (-)NCBI
PanPan1.1X138,985,456 - 139,047,015 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003812307   ⟹   XP_003812355
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,094,427 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,098,034 (-)NCBI
Mhudiblu_PPA_v0X128,737,271 - 128,799,250 (-)NCBI
PanPan1.1X138,985,456 - 139,046,990 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008964704   ⟹   XP_008962952
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,094,428 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,098,040 (-)NCBI
Mhudiblu_PPA_v0X128,738,016 - 128,799,251 (-)NCBI
PanPan1.1X138,986,406 - 139,047,015 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008964705   ⟹   XP_008962953
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,094,425 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,098,031 (-)NCBI
Mhudiblu_PPA_v0X128,737,271 - 128,799,249 (-)NCBI
PanPan1.1X138,985,456 - 139,046,990 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034949775   ⟹   XP_034805666
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,143,551 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,147,149 (-)NCBI
Mhudiblu_PPA_v0X128,737,271 - 128,848,384 (-)NCBI
RefSeq Acc Id: XM_034949776   ⟹   XP_034805667
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,143,548 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,147,147 (-)NCBI
Mhudiblu_PPA_v0X128,737,271 - 128,848,381 (-)NCBI
RefSeq Acc Id: XM_057301078   ⟹   XP_057157061
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,094,426 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,098,031 (-)NCBI
RefSeq Acc Id: XM_057301079   ⟹   XP_057157062
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X139,031,267 - 139,094,428 (-)NCBI
NHGRI_mPanPan1X139,034,869 - 139,098,041 (-)NCBI
RefSeq Acc Id: XP_003812355   ⟸   XM_003812307
- Peptide Label: isoform X8
- UniProtKB: A0A2R9AZY5 (UniProtKB/TrEMBL),   A0A2R9B415 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008962953   ⟸   XM_008964705
- Peptide Label: isoform X6
- UniProtKB: A0A2R9B067 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003812351   ⟸   XM_003812303
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B1D6 (UniProtKB/TrEMBL),   A0A2R9B067 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008962952   ⟸   XM_008964704
- Peptide Label: isoform X4
- UniProtKB: A0A2R9B415 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034805666   ⟸   XM_034949775
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AZX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034805667   ⟸   XM_034949776
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B1C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000022883   ⟸   ENSPPAT00000045697
RefSeq Acc Id: ENSPPAP00000022889   ⟸   ENSPPAT00000045703
RefSeq Acc Id: ENSPPAP00000022893   ⟸   ENSPPAT00000045708
RefSeq Acc Id: ENSPPAP00000022903   ⟸   ENSPPAT00000045718
RefSeq Acc Id: ENSPPAP00000022909   ⟸   ENSPPAT00000045724
RefSeq Acc Id: ENSPPAP00000022906   ⟸   ENSPPAT00000045721
RefSeq Acc Id: ENSPPAP00000022905   ⟸   ENSPPAT00000045720
RefSeq Acc Id: XP_057157062   ⟸   XM_057301079
- Peptide Label: isoform X7
RefSeq Acc Id: XP_057157061   ⟸   XM_057301078
- Peptide Label: isoform X5
Protein Domains
CRAL-TRIO   DH   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045697.1 UniProtKB/TrEMBL
  ENSPPAT00000045703.1 UniProtKB/TrEMBL
  ENSPPAT00000045708.1 UniProtKB/TrEMBL
  ENSPPAT00000045718.1 UniProtKB/TrEMBL
  ENSPPAT00000045720.1 UniProtKB/TrEMBL
  ENSPPAT00000045721.1 UniProtKB/TrEMBL
  ENSPPAT00000045724.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.60 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
NCBI Gene MCF2 ENTREZGENE
PANTHER PROTO-ONCOGENE DBL UniProtKB/TrEMBL
  RHO GUANINE EXCHANGE FACTOR-RELATED UniProtKB/TrEMBL
Pfam CRAL_TRIO_2 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE CRAL_TRIO UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SEC14 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF52087 UniProtKB/TrEMBL
UniProt A0A2R9AZX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AZY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B067 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1C8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1D6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1F0_PANPA UniProtKB/TrEMBL
  A0A2R9B415 ENTREZGENE, UniProtKB/TrEMBL