DOCK1 (dedicator of cytokinesis 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: DOCK1 (dedicator of cytokinesis 1) Pan paniscus
Analyze
Symbol: DOCK1
Name: dedicator of cytokinesis 1
RGD ID: 11793383
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN cell migration (ortholog); hematopoietic progenitor cell differentiation (ortholog); positive regulation of epithelial cell migration (ortholog); ASSOCIATED WITH COVID-19 (ortholog); DiGeorge syndrome (ortholog); distal 10q deletion syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); guanyl-nucleotide exchange factor complex (ortholog); postsynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dedicator of cytokinesis protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28138,770,611 - 139,332,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010123,485,345 - 124,041,337 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110127,744,782 - 128,289,981 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10127,803,236 - 128,288,897 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DOCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28138,770,611 - 139,332,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010123,485,345 - 124,041,337 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110127,744,782 - 128,289,981 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10127,803,236 - 128,288,897 (+)Ensemblpanpan1.1panPan2
DOCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810126,905,428 - 127,452,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10126,905,409 - 127,452,517 (+)EnsemblGRCh38hg38GRCh38
GRCh3710128,593,997 - 129,250,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610128,658,955 - 129,140,770 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410128,658,954 - 129,140,769NCBI
Celera10122,439,168 - 122,921,173 (+)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10122,340,788 - 122,823,487 (+)NCBIHuRef
CHM1_110129,050,827 - 129,533,068 (+)NCBICHM1_1
T2T-CHM13v2.010127,789,114 - 128,347,493 (+)NCBIT2T-CHM13v2.0
Dock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397134,272,416 - 134,775,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7134,272,383 - 134,775,368 (+)EnsemblGRCm39 Ensembl
GRCm387134,670,687 - 135,173,647 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7134,670,654 - 135,173,639 (+)EnsemblGRCm38mm10GRCm38
MGSCv377141,862,370 - 142,365,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367134,509,030 - 135,011,990 (+)NCBIMGSCv36mm8
Celera7134,477,959 - 134,991,792 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map779.14NCBI
Dock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,897,021 - 199,413,636 (+)NCBIGRCr8
mRatBN7.21189,467,143 - 189,983,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1189,467,143 - 189,983,768 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1197,826,434 - 198,344,503 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01204,994,807 - 205,504,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01197,668,299 - 198,177,593 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01206,900,617 - 207,414,852 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1206,900,617 - 207,414,843 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,838,803 - 214,349,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41194,172,914 - 194,795,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1187,188,438 - 187,700,806 (+)NCBICelera
Cytogenetic Map1q41NCBI
Dock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554774,725,039 - 5,243,866 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554774,725,780 - 5,243,812 (+)NCBIChiLan1.0ChiLan1.0
DOCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12835,862,267 - 36,397,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2835,861,523 - 36,396,883 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,960,163 - 36,453,573 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02836,536,271 - 37,030,199 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2836,536,316 - 37,030,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12836,012,508 - 36,505,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02836,009,501 - 36,504,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02836,265,344 - 36,759,122 (+)NCBIUU_Cfam_GSD_1.0
Dock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721310,451,230 - 10,887,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648614,692,532 - 15,092,307 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648614,583,042 - 15,092,164 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14136,257,807 - 136,741,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114136,199,747 - 136,745,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214148,261,860 - 148,289,427 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19119,519,230 - 120,064,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604880,885,791 - 81,444,814 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473719,574,948 - 20,105,265 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473719,575,012 - 20,105,406 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059023   ⟹   ENSPPAP00000036132
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10127,803,236 - 127,880,039 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059091   ⟹   ENSPPAP00000036200
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10127,807,042 - 128,288,897 (+)Ensembl
RefSeq Acc Id: XM_034931698   ⟹   XP_034787589
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28138,770,613 - 139,332,095 (+)NCBI
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBI
Mhudiblu_PPA_v010123,485,345 - 124,041,337 (+)NCBI
RefSeq Acc Id: XM_034931699   ⟹   XP_034787590
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28138,770,614 - 139,332,095 (+)NCBI
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBI
Mhudiblu_PPA_v010123,485,345 - 124,041,336 (+)NCBI
RefSeq Acc Id: XM_034931700   ⟹   XP_034787591
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28138,770,612 - 139,332,095 (+)NCBI
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBI
Mhudiblu_PPA_v010123,485,345 - 124,041,336 (+)NCBI
RefSeq Acc Id: XM_034931701   ⟹   XP_034787592
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28138,770,613 - 139,332,095 (+)NCBI
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBI
Mhudiblu_PPA_v010123,485,345 - 124,041,336 (+)NCBI
RefSeq Acc Id: XM_055093474   ⟹   XP_054949449
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28138,775,097 - 139,332,095 (+)NCBI
NHGRI_mPanPan110138,780,446 - 139,337,446 (+)NCBI
RefSeq Acc Id: XM_063607571   ⟹   XP_063463641
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28138,770,611 - 139,332,095 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034787589   ⟸   XM_034931698
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C2P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787591   ⟸   XM_034931700
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C2P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787590   ⟸   XM_034931699
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C2P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787592   ⟸   XM_034931701
- Peptide Label: isoform X4
- UniProtKB: A0A2R9C2P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000036132   ⟸   ENSPPAT00000059023
RefSeq Acc Id: ENSPPAP00000036200   ⟸   ENSPPAT00000059091
RefSeq Acc Id: XP_054949449   ⟸   XM_055093474
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063463641   ⟸   XM_063607571
- Peptide Label: isoform X6
Protein Domains
C2 DOCK-type   DOCKER   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040838 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059023.1 UniProtKB/TrEMBL
  ENSPPAT00000059091.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.350 UniProtKB/TrEMBL
  1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_DOCK-type_domain UniProtKB/TrEMBL
  C2_DOCKER_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK1_C2 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene DOCK1 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 1 UniProtKB/TrEMBL
  PTHR45653 UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE C2_DOCK UniProtKB/TrEMBL
  DOCKER UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A2R9C2P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CCS3_PANPA UniProtKB/TrEMBL