ATOH1 (atonal bHLH transcription factor 1)

Gene: ATOH1 (atonal bHLH transcription factor 1) Pan paniscus

Analyze

Symbol:

ATOH1

Name:

atonal bHLH transcription factor 1

RGD ID:

11781869

Description:

ENCODES a protein that exhibits chromatin DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN auditory receptor cell fate determination (ortholog); auditory receptor cell fate specification (ortholog); axon guidance (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness (ortholog); Autosomal Dominant Nonsyndromic Deafness 89 (ortholog); Developmental Disabilities (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

atonal homolog 1; transcription factor ATOH1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	91,853,914 - 91,856,688 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	92,132,530 - 92,135,303 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	86,188,534 - 86,191,301 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	96,863,733 - 96,864,905 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	96,863,762 - 96,864,832 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nonsyndromic deafness (ISO)

Autosomal Dominant Nonsyndromic Deafness 89 (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

medulloblastoma (ISO)

pontocerebellar hypoplasia (ISO)

pontocerebellar hypoplasia type 1B (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

auditory receptor cell fate determination (IEA,ISO)

auditory receptor cell fate specification (IEA,ISO)

axon development (IEA)

axon guidance (IEA,ISO)

brain development (IEA,ISO)

cell differentiation (IEA,ISO)

cerebral cortex development (IEA,ISO)

epithelial cell apoptotic process (IEA,ISO)

inner ear auditory receptor cell differentiation (IEA,ISO)

inner ear development (IEA,ISO)

inner ear morphogenesis (IEA,ISO)

negative regulation of epithelial cell apoptotic process (IEA,ISO)

negative regulation of gliogenesis (IEA)

neuroblast migration (IEA,ISO)

neuron differentiation (IEA,ISO)

neuron migration (IEA,ISO)

Notch signaling pathway (IEA,ISO)

positive regulation of inner ear auditory receptor cell differentiation (IEA,ISO)

positive regulation of inner ear receptor cell differentiation (IEA,ISO)

positive regulation of neuron differentiation (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of neuron differentiation (IEA,ISO)

sensory organ development (IEA)

transcription by RNA polymerase II (IEA,ISO)

Cellular Component

nucleus (IEA)

Molecular Function

chromatin DNA binding (IEA)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

E-box binding (IEA)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ATOH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	91,853,914 - 91,856,688 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	92,132,530 - 92,135,303 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	86,188,534 - 86,191,301 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	96,863,733 - 96,864,905 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	96,863,762 - 96,864,832 (+)	Ensembl	panpan1.1		panPan2

ATOH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	93,828,753 - 93,830,964 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	93,828,753 - 93,830,964 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	94,749,904 - 94,752,115 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	94,969,101 - 94,970,165 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	95,107,255 - 95,108,320	NCBI
Celera	4	92,046,181 - 92,047,245 (+)	NCBI		Celera
Cytogenetic Map	4	q22.2	NCBI
HuRef	4	90,487,368 - 90,488,432 (+)	NCBI		HuRef
CHM1_1	4	94,726,590 - 94,727,654 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	97,144,124 - 97,146,335 (+)	NCBI		T2T-CHM13v2.0

Atoh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	64,706,109 - 64,708,229 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	64,706,109 - 64,708,229 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	64,729,125 - 64,731,245 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	64,729,125 - 64,731,245 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	64,679,140 - 64,681,237 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	64,658,735 - 64,660,821 (+)	NCBI		MGSCv36	mm8
Celera	6	66,856,661 - 66,858,758 (+)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	30.03	NCBI

Atoh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	95,241,933 - 95,244,028 (+)	NCBI		GRCr8
mRatBN7.2	4	93,912,068 - 93,914,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	93,912,068 - 93,914,154 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	99,138,821 - 99,140,918 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	94,913,774 - 94,915,871 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	93,336,612 - 93,338,707 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	95,498,003 - 95,500,098 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	95,498,003 - 95,500,089 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	160,284,441 - 160,286,536 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	94,109,650 - 94,111,745 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	88,659,055 - 88,661,150 (+)	NCBI		Celera
Cytogenetic Map	4	q31	NCBI

Atoh1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	4,461,704 - 4,462,756 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	4,461,704 - 4,462,756 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATOH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	16,807,217 - 16,809,294 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	16,807,336 - 16,808,406 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	25,139,203 - 25,141,513 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	16,985,533 - 16,987,838 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	16,985,749 - 16,986,819 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	16,957,560 - 16,959,866 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	16,773,311 - 16,775,500 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	23,118,806 - 23,121,117 (-)	NCBI		UU_Cfam_GSD_1.0

Atoh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	24,908,942 - 24,911,175 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936687	1,436,009 - 1,437,067 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936687	1,435,977 - 1,437,138 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATOH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	125,768,286 - 125,770,545 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	125,768,232 - 125,770,619 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	135,103,515 - 135,105,739 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATOH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	42,098,057 - 42,104,910 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	42,100,996 - 42,102,060 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	20,456,111 - 20,458,324 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atoh1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	21,517,809 - 21,518,864 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	21,517,650 - 21,519,543 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003829902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000026133 ⟹ ENSPPAP00000005858

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	96,863,762 - 96,864,832 (+)	Ensembl

RefSeq Acc Id:

XM_003829902 ⟹ XP_003829950

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	91,853,914 - 91,856,688 (+)	NCBI
NHGRI_mPanPan1	4	92,132,530 - 92,135,303 (+)	NCBI
Mhudiblu_PPA_v0	4	86,188,534 - 86,191,301 (+)	NCBI
PanPan1.1	4	96,863,733 - 96,864,905 (+)	NCBI

Sequence:

show sequence

GATCCTGAGCCTCCGAGCTTTGCAGTGCAATGTCCCGCCTGCTGCATGCAGAAGAGTGGGCTGA
AGTGAAGGAGTTGGGAGACCACCATCGCCAGCCCCAGCCGCATCATCTCCCGCAACCGCCGCCG
CCGCCGCCGCCGCAGCCACCTGCAACTTTGCAGGCGAGAGAGCATCCCGTCTACCCGCCTGAGC
TGTCCCTCCTGGACAGCACCGACCCACGCGCCTGGCTGGCTCCCACTTTGCAGGGCATCTGCAC
GGCACGCGCCGCCCAGTATTTGCTACATTCCCCGGAGCTGGGTGCCTCAGAGGCCGCTGCGCCC
CGGGACGAGGTGGACGGCCGGGGGGAGCTGGTAAGGAGGAGCAGCGGCGGTGCCAGCAGCAGCA
AGAGCCCCGGGCCGGTGAAAGTGCGGGAACAGCTGTGCAAGCTGAAAGGCGGGGTGGTGGTAGA
CGAGCTGGGCTGCAGCCGCCAACGGGCCCCTTCCAGCAAACAGGTGAATGGGGTGCAGAAGCAG
AGACGGCTAGCAGCCAACGCCAGGGAGCGGCGCAGGATGCATGGGCTGAACCACGCCTTCGACC
AGCTGCGCAATGTTATCCCGTCGTTCAACAACGACAAGAAGCTGTCCAAATATGAGACCCTGCA
GATGGCCCAAATCTACATCAACGCCTTGTCCGAGCTGCTACAAACGCCCAGCGGAGGGGAACAG
CCACCGCCGCCTCCAGCCTCCTGCAAAAGCGACCACCACCACCTTCGCACCGCGGCCTCCTATG
AAGGGGGCGCGGGCAACGCGACCGCAGCTGGGGCTCAGCAGGCTTCCGGAGGGAGCCAGCGGCC
GACCCCGCCCGGGAGTTGCCGGACTCGCTTCTCAGCTCCAGCTTCTGCGGGAGGGTACTCGGTG
CAGCTGGACGCTCTGCACTTCTCGACTTTCGAGGACAGCGCCCTGACAGCGATGATGGCGCAAA
AGAATTTGTCTCCTTCTCTCCCCGGGAGCATCTTGCAGCCAGTGCAGGAGGAAAACAGCAAAAC
TTCGCCTCGGTCCCACAGAAGCGACGGGGAATTTTCCCCCCATTCCCATTACAGTGACTCGGAT
GAGGCAAGTTAGGAAGGTGACAGAAGCCTGAAAACTGAGACAGAAACAAAACTGCCCTTTCCCA
GTGCGCGGGAAGCCCCGCGGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_003829950	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000005858
	ENSPPAP00000005858.1

RefSeq Acc Id:

XP_003829950 ⟸ XM_003829902

- UniProtKB:

A0A2R8ZLN0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPPPQPPATLQAREHPVYPPELSLLDSTDPR
AWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVRE
QLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFN
NDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAA
GAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGS
ILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS

hide sequence

RefSeq Acc Id:

ENSPPAP00000005858 ⟸ ENSPPAT00000026133

Protein Domains

bHLH

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000023742	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000026133.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	ATOH1	UniProtKB/TrEMBL
	bHLH_dom	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	pps:100989334	UniProtKB/TrEMBL
NCBI Gene	ATOH1	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED	UniProtKB/TrEMBL
	PTHR19290:SF82	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	A0A2R8ZLN0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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