BLK (BLK proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Gene: BLK (BLK proto-oncogene, Src family tyrosine kinase) Pan paniscus
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Symbol: BLK
Name: BLK proto-oncogene, Src family tyrosine kinase
RGD ID: 11777673
Description: ENCODES a protein that exhibits ATP binding (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); protein tyrosine kinase activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); cell differentiation (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH diabetes mellitus (ortholog); genetic disease (ortholog); Kawasaki disease (ortholog); FOUND IN cytosol (inferred); extrinsic component of cytoplasmic side of plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: B lymphoid tyrosine kinase; tyrosine-protein kinase Blk
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2727,961,701 - 28,032,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan183,988,006 - 4,058,396 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,637,680 - 7,708,914 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BLK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2727,961,701 - 28,032,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan183,988,006 - 4,058,396 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,637,680 - 7,708,914 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BLK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38811,494,387 - 11,564,599 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,486,894 - 11,564,599 (+)EnsemblGRCh38hg38GRCh38
GRCh37811,351,896 - 11,422,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,388,930 - 11,459,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 34811,388,929 - 11,459,516NCBI
Celera810,480,897 - 10,551,454 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,282,885 - 10,353,426 (+)NCBIHuRef
CHM1_1811,416,813 - 11,487,683 (+)NCBICHM1_1
T2T-CHM13v2.088,175,675 - 8,245,838 (-)NCBIT2T-CHM13v2.0
Blk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,610,286 - 63,654,636 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,610,285 - 63,654,486 (-)EnsemblGRCm39 Ensembl
GRCm381463,372,837 - 63,417,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,372,836 - 63,417,037 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,991,674 - 64,036,024 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361462,326,947 - 62,371,297 (-)NCBIMGSCv36mm8
Celera1461,138,348 - 61,182,625 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.25NCBI
Blk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,802,701 - 41,841,004 (-)NCBIGRCr8
mRatBN7.21537,626,746 - 37,665,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,627,039 - 37,665,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,479,764 - 39,517,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,630,559 - 40,668,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,087,624 - 39,125,646 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,555,552 - 46,593,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,555,188 - 46,593,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,317,854 - 50,355,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,643,847 - 42,682,793 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,659,818 - 42,698,493 (-)NCBI
Celera1537,310,648 - 37,348,449 (-)NCBICelera
Cytogenetic Map15p12NCBI
Blk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540352,832,604 - 52,874,264 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540352,825,397 - 52,874,007 (+)NCBIChiLan1.0ChiLan1.0
BLK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,336,253 - 26,357,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,336,892 - 26,358,015 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,989,229 - 27,064,576 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02526,487,019 - 26,562,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,487,603 - 26,562,224 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,439,922 - 26,514,938 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,336,943 - 26,412,007 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,488,713 - 26,563,761 (-)NCBIUU_Cfam_GSD_1.0
Blk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049435,339,527 - 5,357,038 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366753,229,154 - 3,246,292 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366753,228,982 - 3,246,617 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BLK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1414,688,943 - 14,745,947 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11414,688,489 - 14,745,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21415,895,128 - 15,934,019 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BLK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,547,200 - 7,618,645 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl87,547,299 - 7,569,188 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605234,810,867 - 34,883,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Blk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475825,129,853 - 25,181,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475825,129,922 - 25,180,180 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003805320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_003805320   ⟹   XP_003805368
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2727,961,701 - 28,032,048 (+)NCBI
NHGRI_mPanPan183,988,006 - 4,058,396 (+)NCBI
Mhudiblu_PPA_v087,637,680 - 7,708,914 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003805368 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000003082
  ENSPPAP00000003082.1
RefSeq Acc Id: XP_003805368   ⟸   XM_003805320
- UniProtKB: A0A2R8ZDG4 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000012991 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000014233.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Blk_SH2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report pps:100989728 UniProtKB/TrEMBL
NCBI Gene BLK ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE BLK UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R8ZDG4 ENTREZGENE, UniProtKB/TrEMBL