PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1) - Rat Genome Database

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Gene: PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1) Pan paniscus
Analyze
Symbol: PLEKHG1
Name: pleckstrin homology and RhoGEF domain containing G1
RGD ID: 11773003
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); small GTPase binding (inferred); ASSOCIATED WITH chromosome 6q24-q25 deletion syndrome (ortholog); prostate cancer (ortholog); Tobacco Use Disorder (ortholog); FOUND IN nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family G member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25170,618,043 - 170,864,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16168,511,574 - 168,755,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06148,411,676 - 148,657,616 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,169,535 - 153,362,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,240,586 - 153,362,070 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLEKHG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25170,618,043 - 170,864,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16168,511,574 - 168,755,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06148,411,676 - 148,657,616 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,169,535 - 153,362,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,240,586 - 153,362,070 (+)Ensemblpanpan1.1panPan2
PLEKHG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386150,599,885 - 150,843,665 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6150,599,883 - 150,843,665 (+)EnsemblGRCh38hg38GRCh38
GRCh376150,921,021 - 151,164,801 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,962,692 - 151,206,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 346151,217,894 - 151,256,913NCBI
Celera6151,655,965 - 151,898,659 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6148,515,324 - 148,728,369 (+)NCBIHuRef
CHM1_16151,184,815 - 151,428,538 (+)NCBICHM1_1
T2T-CHM13v2.06151,800,395 - 152,044,215 (+)NCBIT2T-CHM13v2.0
Plekhg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,690,206 - 3,917,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl103,690,364 - 3,917,303 (+)EnsemblGRCm39 Ensembl
GRCm38103,740,251 - 3,967,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,740,364 - 3,967,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37106,379,238 - 6,606,164 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36106,381,992 - 6,473,874 (-)NCBIMGSCv36mm8
Celera103,669,512 - 3,895,132 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
Plekhg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,612,023 - 42,841,727 (+)NCBIGRCr8
mRatBN7.2140,348,684 - 40,434,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,311,221 - 40,434,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx140,875,690 - 40,961,087 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,862,884 - 46,948,285 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0140,951,325 - 41,036,723 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,286,908 - 40,521,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,389,638 - 40,520,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,637,081 - 41,868,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,591,855 - 34,677,812 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera136,040,218 - 36,125,350 (+)NCBICelera
Cytogenetic Map1p11NCBI
Plekhg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,636,381 - 10,746,745 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,636,444 - 10,755,814 (-)NCBIChiLan1.0ChiLan1.0
PLEKHG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,073,748 - 41,297,380 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,072,500 - 41,295,138 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha141,914,652 - 42,138,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0141,258,670 - 41,482,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,313,940 - 41,479,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,133,917 - 41,357,417 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,977,666 - 41,201,291 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0141,481,825 - 41,705,985 (+)NCBIUU_Cfam_GSD_1.0
Plekhg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,508,740 - 136,589,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364893,760,831 - 3,838,926 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364893,635,960 - 3,840,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,341,638 - 15,587,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,341,634 - 15,588,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLEKHG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,034,968 - 78,285,288 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,154,150 - 78,287,996 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604050,337,476 - 50,580,807 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247857,338,592 - 7,513,435 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247857,340,310 - 7,590,385 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000058095   ⟹   ENSPPAP00000035207
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6153,240,586 - 153,362,070 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000058111   ⟹   ENSPPAP00000035223
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6153,253,478 - 153,359,330 (+)Ensembl
RefSeq Acc Id: XM_003811506   ⟹   XP_003811554
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25170,739,896 - 170,864,097 (+)NCBI
NHGRI_mPanPan16168,633,279 - 168,755,296 (+)NCBI
Mhudiblu_PPA_v06148,533,447 - 148,657,616 (+)NCBI
PanPan1.16153,240,440 - 153,362,070 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024929265   ⟹   XP_024785033
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25170,701,732 - 170,864,097 (+)NCBI
NHGRI_mPanPan16168,595,129 - 168,755,296 (+)NCBI
Mhudiblu_PPA_v06148,495,278 - 148,657,616 (+)NCBI
PanPan1.16153,202,355 - 153,362,070 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034963086   ⟹   XP_034818977
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25170,739,896 - 170,864,097 (+)NCBI
NHGRI_mPanPan16168,633,279 - 168,755,296 (+)NCBI
Mhudiblu_PPA_v06148,533,447 - 148,657,616 (+)NCBI
RefSeq Acc Id: XM_057302611   ⟹   XP_057158594
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25170,668,955 - 170,864,097 (+)NCBI
NHGRI_mPanPan16168,560,351 - 168,755,296 (+)NCBI
RefSeq Acc Id: XM_063605030   ⟹   XP_063461100
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25170,618,043 - 170,864,097 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003811554   ⟸   XM_003811506
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BZW5 (UniProtKB/TrEMBL),   A0A2R9BZW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024785033   ⟸   XM_024929265
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BZW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034818977   ⟸   XM_034963086
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BZW5 (UniProtKB/TrEMBL),   A0A2R9BZW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000035207   ⟸   ENSPPAT00000058095
RefSeq Acc Id: ENSPPAP00000035223   ⟸   ENSPPAT00000058111
RefSeq Acc Id: XP_057158594   ⟸   XM_057302611
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BZW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063461100   ⟸   XM_063605030
- Peptide Label: isoform X2
Protein Domains
DH   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058095.1 UniProtKB/TrEMBL
  ENSPPAT00000058111.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_PLEKHG1_G2_G3 UniProtKB/TrEMBL
KEGG Report pps:100984175 UniProtKB/TrEMBL
NCBI Gene PLEKHG1 ENTREZGENE
PANTHER FI17866P1 UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 1 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A2R9BZW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BZW9 ENTREZGENE, UniProtKB/TrEMBL