CST7 (cystatin F) - Rat Genome Database

Name: CST7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: CST7 (cystatin F) Pan paniscus

Analyze

Symbol:

CST7

Name:

cystatin F

RGD ID:

11758028

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); protein homodimerization activity (inferred); INVOLVED IN negative regulation of microglial cell activation (ortholog); positive regulation of myelination (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic vesicle (inferred); endoplasmic reticulum (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cystatin-F

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CST7 (cystatin F)	NCBI	Ortholog
Mus musculus (house mouse):	Cst7 (cystatin F (leukocystatin))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cst7 (cystatin F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cst7 (cystatin F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CST7 (cystatin F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cst7 (cystatin F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CST7 (cystatin F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cst7 (cystatin F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	25,820,558 - 25,831,580 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	25,817,391 - 25,828,414 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	24,889,834 - 24,900,766 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	25,237,251 - 25,248,364 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	25,237,251 - 25,248,364 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

immune response (IEA)

negative regulation of microglial cell activation (IEA,ISO)

positive regulation of myelination (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

endoplasmic reticulum (IEA)

endosome (IEA)

extracellular space (IEA)

Golgi apparatus (IEA)

late endosome (IEA)

lysosome (IEA)

multivesicular body (IEA)

Molecular Function

cysteine-type endopeptidase inhibitor activity (IEA)

peptidase inhibitor activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CST7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	25,820,558 - 25,831,580 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	25,817,391 - 25,828,414 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	24,889,834 - 24,900,766 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	25,237,251 - 25,248,364 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	25,237,251 - 25,248,364 (+)	Ensembl	panpan1.1		panPan2

CST7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	24,949,269 - 24,959,928 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	24,949,269 - 24,959,928 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	24,929,905 - 24,940,564 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	24,877,866 - 24,888,562 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	24,877,865 - 24,888,562	NCBI
Celera	20	25,003,521 - 25,014,368 (+)	NCBI		Celera
Cytogenetic Map	20	p11.21	NCBI
HuRef	20	24,886,598 - 24,897,456 (+)	NCBI		HuRef
CHM1_1	20	24,930,375 - 24,941,053 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	25,013,382 - 25,024,201 (+)	NCBI		T2T-CHM13v2.0

Cst7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	150,412,335 - 150,420,864 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	150,412,335 - 150,420,864 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	150,570,415 - 150,578,944 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	150,570,415 - 150,578,944 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	150,396,151 - 150,404,680 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	150,261,875 - 150,270,383 (+)	NCBI		MGSCv36	mm8
Celera	2	151,805,324 - 151,813,854 (+)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	74.67	NCBI

Cst7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	159,857,221 - 159,865,987 (+)	NCBI		GRCr8
mRatBN7.2	3	139,396,830 - 139,405,557 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,396,850 - 139,405,557 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,293,599 - 143,302,310 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	151,877,342 - 151,886,053 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,625,444 - 149,634,155 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,363,913 - 146,373,365 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,365,092 - 146,373,365 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,726,245 - 152,736,007 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,188,442 - 141,199,756 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	141,074,327 - 141,104,838 (+)	NCBI
Celera	3	138,160,316 - 138,169,038 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

Cst7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,082,978 - 31,086,379 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	31,082,978 - 31,086,379 (+)	NCBI	ChiLan1.0	ChiLan1.0

CST7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	1,136,161 - 1,145,411 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	1,136,258 - 1,144,983 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	1,166,587 - 1,175,839 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	1,379,118 - 1,388,571 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	1,379,217 - 1,388,143 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	1,194,770 - 1,204,020 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	1,324,938 - 1,334,191 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	1,307,878 - 1,317,130 (+)	NCBI		UU_Cfam_GSD_1.0

Cst7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	147,435,685 - 147,450,362 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936620	853,439 - 870,812 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936620	853,533 - 870,609 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CST7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	30,758,000 - 30,766,472 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	30,758,000 - 30,766,472 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	34,906,655 - 34,915,135 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Cst7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624939	471,706 - 475,545 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624939	471,699 - 475,338 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003829359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000037016 ⟹ ENSPPAP00000014334

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	25,237,251 - 25,248,364 (+)	Ensembl

RefSeq Acc Id:

XM_003829359 ⟹ XP_003829407

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	25,820,558 - 25,831,580 (+)	NCBI
NHGRI_mPanPan1	20	25,817,391 - 25,828,414 (+)	NCBI
Mhudiblu_PPA_v0	20	24,889,834 - 24,900,766 (+)	NCBI
PanPan1.1	20	25,237,251 - 25,248,364 (+)	NCBI

Sequence:

show sequence

TGCTGTGGCCCCGGCACCTGCCCCTGGGCTGGGACAGCCCACTGTTCTGTGCTGCCCGAGAAGG
CTCAGTACAGGCACAAACCACTGCCCGGCACTGCCCCGTGCTGCCTGAGAAGGATTGGCACGAG
CACAGACCACTGCCCCCACCTGCCCTGCGCCATCTACCCAAGAAGGCTCGGCACGGGCACCAAC
CACTGCCTCCAACTGCCCCATGCTGCCTGAGAAGGCACTGCACGGCCACCCCCAACTGCCCCGC
ACTGTCCCCACCCGGGCAGCCATGCGAGCGGCTGGAACTCTGCTGGCCTTCTGCTGCCTGGTCT
TGAGCACCACTGGGGGCCCTTCCCCAGATACTTGTTCCCAGGACCTTAACTCAGGTGTGAAGCC
AGGATTTCCTAAAACAATAAAGACCAACGACCCAGGAGTCCTCCAAGCAGCCAGATACAGTGTT
GAAAAGTTCAACAACTGCACGAACGACATGTTCTTGTTCAAGGAGTCCCGCATCACAAGGGCCC
TAGTTCAGATAGTGAAAGGCCTGAAATATATGCTCGAGGTGGAAATTGGCAGAACTACCTGCAA
GAAAAACCAGCACCCGCGTCTGGATGACTGTGACTTCCAAACCAACCACACCTTGAAGCGGACT
CTGAGCTGCTACTCTGAAGTCTGGGTCGTGCCCTGGCTCCAGCACTTCGAGGTGCCTGTTCTCC
GTTGTCACTGACCCCCGCCTCTTCAGCAAGACCACAGCCGTGACAAACACCAGGATGCATGCTC
CTTGTCCCCTCCCACCCGCCTCATGACCCAGCCTCACAGACCCTCTCAGGCCTCTGACGAGTGA
GCAGGTGAAGTGCCACTGGGTCACCACAGGGCAGCTGGAATGGCAGCATGGTAGCGCCTCCTAA
CAGATTAAATAGATCACATTTGCTTCTAAAATTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003829407	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000014334
	ENSPPAP00000014334.1

RefSeq Acc Id:	XP_003829407 ⟸ XM_003829359
- UniProtKB:	A0A2R9AAP1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPEKALHGHPQLPRTVPTRAAMRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSGVKPGFPKTI KTNDPGVLQAARYSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHPR LDDCDFQTNHTLKRTLSCYSEVWVVPWLQHFEVPVLRCH hide sequence

RefSeq Acc Id:

ENSPPAP00000014334 ⟸ ENSPPAT00000037016

Protein Domains

Cystatin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000030321	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000037016.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.10	UniProtKB/TrEMBL
InterPro	Cystatin-F	UniProtKB/TrEMBL
	Cystatin_dom	UniProtKB/TrEMBL
	Cystatin_sf	UniProtKB/TrEMBL
NCBI Gene	CST7	ENTREZGENE
PANTHER	CYSTATIN-F	UniProtKB/TrEMBL
	PTHR47141	UniProtKB/TrEMBL
Pfam	Cystatin	UniProtKB/TrEMBL
SMART	SM00043	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54403	UniProtKB/TrEMBL
UniProt	A0A2R9AAP1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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