PIAS4 (protein inhibitor of activated STAT 4) - Rat Genome Database

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Gene: PIAS4 (protein inhibitor of activated STAT 4) Pan paniscus
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Symbol: PIAS4
Name: protein inhibitor of activated STAT 4
RGD ID: 11754600
Description: ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); SUMO ligase activity (inferred); INVOLVED IN central nervous system development (ortholog); hair follicle development (ortholog); limb epidermis development (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Jak-Stat signaling pathway; type II interferon signaling pathway; ASSOCIATED WITH amenorrhea (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); nuclear matrix (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 SUMO-protein ligase PIAS4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,403,736 - 8,436,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,634,962 - 7,666,709 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,030,885 - 3,062,642 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,983,200 - 4,012,686 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,982,555 - 4,015,167 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PIAS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,403,736 - 8,436,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,634,962 - 7,666,709 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,030,885 - 3,062,642 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,983,200 - 4,012,686 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,982,555 - 4,015,167 (+)Ensemblpanpan1.1panPan2
PIAS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,007,736 - 4,039,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,007,736 - 4,039,386 (+)EnsemblGRCh38hg38GRCh38
GRCh37194,007,734 - 4,039,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,958,749 - 3,989,067 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,958,748 - 3,989,066NCBI
Celera193,947,561 - 3,977,562 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,801,741 - 3,802,439 (+)NCBIHuRef
HuRef193,773,215 - 3,799,042 (+)NCBIHuRef
CHM1_1194,007,373 - 4,037,381 (+)NCBICHM1_1
T2T-CHM13v2.0193,989,995 - 4,022,498 (+)NCBIT2T-CHM13v2.0
Pias4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,989,795 - 81,003,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,989,100 - 81,003,757 (-)EnsemblGRCm39 Ensembl
GRCm381081,153,961 - 81,167,720 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,153,266 - 81,167,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,616,706 - 80,630,465 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,557,090 - 80,571,052 (-)NCBIMGSCv36mm8
Celera1082,174,317 - 82,188,076 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Pias4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,197,032 - 9,210,557 (+)NCBIGRCr8
mRatBN7.278,546,312 - 8,559,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,546,312 - 8,559,808 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,431,397 - 11,444,919 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,306,884 - 13,320,406 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,173,320 - 11,186,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,414,565 - 11,428,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,414,446 - 11,428,552 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,581,929 - 11,595,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,030,125 - 10,043,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,029,966 - 10,042,933 (+)NCBI
Celera76,734,179 - 6,747,704 (+)NCBICelera
Cytogenetic Map7q11NCBI
Pias4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,761,862 - 4,791,490 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,760,576 - 4,791,422 (-)NCBIChiLan1.0ChiLan1.0
PIAS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,529,841 - 55,553,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,524,443 - 55,553,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,255,747 - 55,279,377 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,189,988 - 56,213,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,190,023 - 56,214,314 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,246,339 - 55,269,941 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,727,726 - 55,751,327 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,926,678 - 55,950,158 (-)NCBIUU_Cfam_GSD_1.0
Pias4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,531,908 - 215,546,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,287,996 - 2,302,691 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,287,941 - 2,302,875 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIAS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,702,945 - 74,729,775 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,702,915 - 74,729,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,247,311 - 75,274,180 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIAS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,768,100 - 3,797,377 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660814,446,258 - 4,476,734 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pias4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,551,749 - 5,572,570 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,551,538 - 5,572,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000041435   ⟹   ENSPPAP00000018698
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl193,982,555 - 4,015,167 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000041440   ⟹   ENSPPAP00000018703
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl193,982,555 - 4,012,656 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000041459   ⟹   ENSPPAP00000018720
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl193,983,181 - 4,012,674 (+)Ensembl
RefSeq Acc Id: XM_003819270   ⟹   XP_003819318
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,404,073 - 8,436,580 (+)NCBI
NHGRI_mPanPan1197,635,284 - 7,666,709 (+)NCBI
Mhudiblu_PPA_v0193,033,609 - 3,062,642 (+)NCBI
PanPan1.1193,983,200 - 4,012,686 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034944464   ⟹   XP_034800355
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,403,736 - 8,436,580 (+)NCBI
NHGRI_mPanPan1197,634,962 - 7,666,709 (+)NCBI
Mhudiblu_PPA_v0193,030,885 - 3,062,642 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003819318 (Get FASTA)   NCBI Sequence Viewer  
  XP_034800355 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000018698.1
  ENSPPAP00000018703.1
  ENSPPAP00000018720.1
RefSeq Acc Id: XP_003819318   ⟸   XM_003819270
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034800355   ⟸   XM_034944464
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000018698   ⟸   ENSPPAT00000041435
RefSeq Acc Id: ENSPPAP00000018703   ⟸   ENSPPAT00000041440
RefSeq Acc Id: ENSPPAP00000018720   ⟸   ENSPPAT00000041459
Protein Domains
PINIT   SAP   SP-RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000041435.1 UniProtKB/TrEMBL
  ENSPPAT00000041440.1 UniProtKB/TrEMBL
  ENSPPAT00000041459.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  2.60.120.780 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro PINIT UniProtKB/TrEMBL
  PINIT_sf UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
  Znf_MIZ UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene PIAS4 ENTREZGENE
PANTHER PTHR10782:SF9 UniProtKB/TrEMBL
  ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam PINIT UniProtKB/TrEMBL
  zf-MIZ UniProtKB/TrEMBL
PROSITE PINIT UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
  ZF_SP_RING UniProtKB/TrEMBL
SMART SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt A0A2R9ANH2_PANPA UniProtKB/TrEMBL
  A0A2R9ANH6_PANPA UniProtKB/TrEMBL
  A0A2R9ASG7_PANPA UniProtKB/TrEMBL